Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure–activity relationships

Wun-Chang Ko; Chwen-Ming Shih; Ya-Hsin Lai; Jun-Hao Chen; Hui-Lin Huang

doi:10.1016/j.bcp.2004.06.030

journal article Nov 01, 2004

Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure–activity relationships

Wun-Chang Ko Chwen-Ming Shih Ya-Hsin Lai Jun-Hao Chen Hui-Lin Huang

Biochemical Pharmacology Vol. 68 No. 10 pp. 2087-2094 · Elsevier BV

View at Publisher Save 10.1016/j.bcp.2004.06.030

Topics

No keywords indexed for this article. Browse by subject →

References

46

[1]

Lee "Crystal structure of phosphodiesterase 4D and inhibitor complex" FEBS Lett. (2002) 10.1016/s0014-5793(02)03396-3

[2]

Torphy "Characterization and selective inhibition of cyclic nucleotide phosphodiesterase isozymes in canine tracheal smooth muscle" Mol. Pharmacol. (1990)

[3]

Kapui "Experimental studies on guanosine 3′, 5′-cyclic monophosphate levels and airway responsiveness of the novel phosphodiesterase type 5 inhibitor SR 265579 in guinea-pigs" Drug Res. (1999)

[4]

De Boer "Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: biochemical and pharmacological analysis using selective inhibitors" Br. J. Pharmacol. (1992) 10.1111/j.1476-5381.1992.tb14451.x

[5]

Silver "Differential pharmacologic sensitivity of cyclic nucleotide phosphodiesterase isozymes isolated from cardiac muscle, arterial and airway smooth muscle" Eur. J. Pharmacol. (1988) 10.1016/0014-2999(88)90753-4

[6]

Underwood "Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs" J. Pharmacol. Exp. Ther. (1994)

[7]

Kuhnau "The flavonoids: a class of semi-essential food components: their role in human nutrition" World Rev. Nut. Diet. (1976) 10.1159/000399407

[8]

Chen "Flavonoids as superoxide scavengers and antioxidants" Free Radic. Biol. Med. (1990) 10.1016/0891-5849(90)90045-k

[9]

Ferrandiz "Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids" Agent Act (1991) 10.1007/bf01980887

[10]

Menon "Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds" Cancer Lett. (1995) 10.1016/0304-3835(95)03887-3

[11]

Edenhardder "Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and heterocyclic amine mutagens from cooked food" Mutat. Res. (1993) 10.1016/0027-5107(93)90019-c

[12]

Duarte "Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure–activity relationships" Gen Pharmacol. (1993) 10.1016/0306-3623(93)90159-u

[13]

Hayashi "Inhibition of cow's milk xanthine oxidase by flavonoids" J. Nat. Prod. (1988) 10.1021/np50056a030

[14]

Ferriola "Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure–activity relationships" Biochem. Pharmacol. (1989) 10.1016/0006-2952(89)90309-2

[15]

Kuppusamy "Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilization in rat adipocytes" Biochem. Pharmacol. (1992) 10.1016/0006-2952(92)90531-m

[16]

Ko "3-O-Methylquercetin more selectively inhibits phosphodiesterase subtype 3" Planta Med. (2003) 10.1055/s-2003-38874

[17]

Thompson "Multiple cyclic nucleotide phosphodiesterase activities from rat brain" Biochemistry (1971) 10.1021/bi00778a018

[18]

Ahn "Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta" Biochem. Pharmacol. (1989) 10.1016/0006-2952(89)90631-x

[19]

Mery "Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic GMP-stimulated phosphodiesterase in isolated cardiac myocytes" Mol. Pharmacol. (1995)

[20]

Harrison "Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs" Mol. Pharmacol. (1986)

[21]

Sheppard "Structure–activity relationships for inhibitors of phosphodiesterase from erythrocytes and other tissues" Adv. Cyclic Nucleotide Res. (1972)

[22]

Gillespie "Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M&B 22,948" Mol. Pharmacol. (1989)

[23]

Ko "Relaxant effects of flavonoids in isolated guinea pig trachea and their structure–activity relationships" Planta Med. (2003) 10.1055/s-2003-45187

[24]

Cos "Cytotoxicity and lipid peroxidation-inhibiting activity of flavonoids" Planta Med. (2001) 10.1055/s-2001-16472

[25]

Kim "Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure–activity relationships" Biochem. Pharmacol. (1999) 10.1016/s0006-2952(99)00160-4

[26]

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

T. Akiyama, J. Ishida, S. Nakagawa et al.

Journal of Biological Chemistry 1987 10.1016/s0021-9258(18)45614-1

[27]

Nichols "Differential inhibition of multiple cAMP phosphodiesterase isozymes by isoflavones and tyrphostins" Mol. Pharmacol. (2000) 10.1124/mol.57.4.738

[28]

Rybalkin "Cyclic GMP phosphodiesterases and regulation of smooth muscle function" Circ. Res. (2003) 10.1161/01.res.0000087541.15600.2b

[29]

Giembycz "Phosphodiesterase 4 inhibitors and the treatment of asthma. Where are we now and where do we go from here?" Drug (2000) 10.2165/00003495-200059020-00004

[30]

Torphy "Phosphodiesterase isozymes, molecular targets for novel antiasthma agents" Am. J. Respir. Crit. Care Med. (1998) 10.1164/ajrccm.157.2.9708012

[31]

Masuoka "Two isoforms of cGMP-inhibited cyclic nucleotide phosphodiesterases in human tissues distinguished by their responses to vesnarinone, a new cardiotonic agent" Biochem. Biophys. Res. Commun. (1993) 10.1006/bbrc.1993.1063

[32]

Moon "Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia" Clin. Cancer Res. (2002)

[33]

Thompson "Exisulind induction of apoptosis involves guanosine 3′,5′-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin" Cancer Res. (2000)

[34]

Thompson "Sulfone metabolite of sulindac inhibits mammary carcinogenesis" Cancer Res. (1997)

[35]

Lim "Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines" Biochem. Pharmacol. (1999) 10.1016/s0006-2952(99)00200-2

[36]

Li "Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation" Biochem. Pharmacol. (2002) 10.1016/s0006-2952(02)01345-x

[37]

Schneider "Stereospecific binding of the antidepressant rolipram to brain protein structures" Eur. J. Pharmacol. (1986) 10.1016/0014-2999(86)90210-4

[38]

Zhu "Cyclic AMP-specific phosphodiesterase inhibitor rolipram and Ro 20-1724 promoted apoptosis in HL60 promyelocytic leukemic cells via cyclic AMP-independent mechanism" Life Sci. (1998) 10.1016/s0024-3205(98)00270-7

[39]

Marko "Induction of apoptosis by an inhibitor of cAMP-specific PDE in malignant murine carcinoma cells overexpressing PDE activity in comparison to their nonmalignant counterparts" Cell Biochem. Biophys. (1998) 10.1007/bf02737806

[40]

Kim "Type 4 cyclic adenosine monophosphate phosphodiesterase as a therapeutic target in chronic lymphocytic leukemia" Blood (1998) 10.1182/blood.v92.7.2484

[41]

Siegmund "Phosphodiesterase type 4 inhibitor suppresses expression of anti-apoptotic members of the Bcl-2 family in B-CLL cells and induces caspase-dependent apoptosis" Leukemia (2001) 10.1038/sj.leu.2402232

[42]

Kazi "Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein" Biochem. Pharmacol. (2003) 10.1016/s0006-2952(03)00414-3

[43]

Karp "Timed sequential therapy of acute leukemia with flavopiridol: in vitro model for a phase I clinical trial" Clin. Cancer Res. (2003)

[44]

Aklilu "Phase II study of flavopiridol in patients with advanced colorectal cancer" Ann. Oncol. (2003) 10.1093/annonc/mdg343

[45]

Senderowicz "Preclinical and clinical development of cyclin-dependent kinase modulators" J. Natl. Cancer Inst. (2000) 10.1093/jnci/92.5.376

[46]

Senderowicz "Small-molecule cyclin-dependent kinase modulators" Oncogene (2003) 10.1038/sj.onc.1206954

Cited By

133

Synthesis, Biological Evaluation and Docking Studies of Chalcone and Flavone Analogs as Antioxidants and Acetylcholinesterase Inhibitors

Laura Díaz-Rubio, Rufina Hernández-Martínez · 2019

Applied Sciences

Metrics

133

Citations

46

References

Details

Published: Nov 01, 2004
Vol/Issue: 68(10)
Pages: 2087-2094
License: View

Authors

Cite This Article

Wun-Chang Ko, Chwen-Ming Shih, Ya-Hsin Lai, et al. (2004). Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure–activity relationships. Biochemical Pharmacology, 68(10), 2087-2094. https://doi.org/10.1016/j.bcp.2004.06.030

Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure–activity relationships

You May Also Like