Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation

Michael R. Irwin; Richard Olmstead; Judith E. Carroll

doi:10.1016/j.biopsych.2015.05.014

journal article Jul 01, 2016

Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation

Michael R. Irwin

Richard Olmstead

Judith E. Carroll

Biological Psychiatry Vol. 80 No. 1 pp. 40-52 · Elsevier BV

View at Publisher Save 10.1016/j.biopsych.2015.05.014

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References

126

[1]

Dew "Healthy older adults’ sleep predicts all-cause mortality at 4 to 19 years of follow-up" Psychosom Med (2003) 10.1097/01.psy.0000039756.23250.7c

[2]

Kripke "Mortality associated with sleep duration and insomnia" Arch Gen Psychiatry (2002) 10.1001/archpsyc.59.2.131

[3]

Mallon "Sleep complaints predict coronary artery disease mortality in males: A 12-year follow-up study of a middle-aged Swedish population" J Intern Med (2002) 10.1046/j.1365-2796.2002.00941.x

[4]

Vgontzas "Insomnia with objective short sleep duration: The most biologically severe phenotype of the disorder" Sleep Med Rev (2013) 10.1016/j.smrv.2012.09.005

[5]

LeBlanc "Incidence and risk factors of insomnia in a population-based sample" Sleep (2009) 10.1093/sleep/32.8.1027

[6]

Morin "The natural history of insomnia: A population-based 3-year longitudinal study" Arch Intern Med (2009) 10.1001/archinternmed.2008.610

[7]

Ohayon "Epidemiology of insomnia: What we know and what we still need to learn" Sleep Med Rev (2002) 10.1053/smrv.2002.0186

[8]

Buysse "Sleep health: Can we define it? Does it matter?" Sleep (2014) 10.5665/sleep.3298

[9]

Irwin "Why sleep is important for health: A psychoneuroimmunology perspective" Annu Rev Psychol 66 (2015)

[10]

Ridker "Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events" N Engl J Med (2002) 10.1056/nejmoa021993

[11]

Ridker "C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: An 8-year follow-up of 14 719 initially healthy American women" Circulation (2003) 10.1161/01.cir.0000055014.62083.05

[12]

Sesso "C-reactive protein and the risk of developing hypertension" JAMA (2003) 10.1001/jama.290.22.2945

[13]

Barzilay "The association of markers of inflammation with weight change in older adults: The Cardiovascular Health Study" Int J Obes (Lond) (2006) 10.1038/sj.ijo.0803306

[14]

Irwin "Reciprocal regulation of the neural and innate immune systems" Nat Rev Immunol (2011) 10.1038/nri3042

[15]

Brunner "Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream" PLoS Med (2008) 10.1371/journal.pmed.0050155

[16]

Irwin "Tai Chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: A randomized controlled trial" J Natl Cancer Inst Monogr (2014) 10.1093/jncimonographs/lgu028

[17]

Irwin "Cognitive behavioral therapy vs. Tai Chi for late life insomnia and inflammatory risk: A randomized controlled comparative efficacy trial" Sleep (2014) 10.5665/sleep.4008

[18]

Irwin "Cognitive behavioral therapy and Tai Chi reverse cellular and genomic markers of inflammation in late life insomnia: A randomized controlled trial" Biol Psychiatry (2015) 10.1016/j.biopsych.2015.01.010

[19]

Xie "Effects of continuous positive airway pressure therapy on systemic inflammation in obstructive sleep apnea: A meta-analysis" Sleep Med (2013) 10.1016/j.sleep.2013.07.006

[20]

Erten "Relationship between sleep complaints and proinflammatory cytokines in haemodialysis patients" Nephrology (Carlton) (2005) 10.1111/j.1440-1797.2005.00418.x

[21]

Hong "The association between interleukin-6, sleep, and demographic characteristics" Brain Behav Immun (2005) 10.1016/j.bbi.2004.07.008

[22]

Lee "Nocturnal sleep related with metabolic markers in end-stage renal disease patients receiving hemodialysis" Psychiatry Investig (2009) 10.4306/pi.2009.6.1.34

[23]

Mills "Inflammation and sleep in healthy individuals" Sleep (2007) 10.1093/sleep/30.6.729

[24]

Sprod "Exercise, sleep quality, and mediators of sleep in breast and prostate cancer patients receiving radiation therapy" Community Oncol (2010) 10.1016/s1548-5315(11)70427-2

[25]

von Kanel "Poor sleep is associated with higher plasma proinflammatory cytokine interleukin-6 and procoagulant marker fibrin D-dimer in older caregivers of people with Alzheimer’s disease" J Am Geriatr Soc (2006) 10.1111/j.1532-5415.2005.00642.x

[26]

Almeida "Complaints of difficulty to fall asleep increase the risk of depression in later life: The health in men study" J Affect Disord (2011) 10.1016/j.jad.2011.05.045

[27]

Jackowska "Sleep and biomarkers in the English Longitudinal Study of Ageing: Associations with C-reactive protein, fibrinogen, dehydroepiandrosterone sulfate and hemoglobin" Psychoneuroendocrinology (2013) 10.1016/j.psyneuen.2012.12.015

[28]

Laugsand "Insomnia and high-sensitivity C-reactive protein: The HUNT study, Norway" Psychosom Med (2012) 10.1097/psy.0b013e31825904eb

[29]

Lavie "Elevated plasma homocysteine in older shift-workers: A potential risk factor for cardiovascular morbidity" Chronobiol Int (2007) 10.1080/07420520601139797

[30]

Liukkonen "C-reactive protein levels and sleep disturbances: Observations based on the Northern Finland 1966 Birth Cohort study" Psychosom Med (2007) 10.1097/psy.0b013e318157cb96

[31]

McDade "Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: The Chicago health, aging, and social relations study" Psychosom Med (2006) 10.1097/01.psy.0000221371.43607.64

[32]

Zhang "Differentiating nonrestorative sleep from nocturnal insomnia symptoms: Demographic, clinical, inflammatory, and functional correlates" Sleep (2013) 10.5665/sleep.2624

[33]

Bower "Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer" Clin Cancer Res (2009) 10.1158/1078-0432.ccr-08-2584

[34]

Burgos "Increased nocturnal interleukin-6 excretion in patients with primary insomnia: A pilot study" Brain Behav Immun (2006) 10.1016/j.bbi.2005.06.007

[35]

Chiu "Higher systemic inflammation is associated with poorer sleep quality in stable haemodialysis patients" Nephrol Dial Transplant (2009) 10.1093/ndt/gfn439

[36]

Christian "Poorer self-rated health is associated with elevated inflammatory markers among older adults" Psychoneuroendocrinolgy (2011) 10.1016/j.psyneuen.2011.04.003

[37]

Clevenger "Sleep disturbance, cytokines, and fatigue in women with ovarian cancer" Brain Behav Immun (2012) 10.1016/j.bbi.2012.04.003

[38]

Dowd "Sleep duration, sleep quality, and biomarkers of inflammation in a Taiwanese population" Ann Epidemiol (2011) 10.1016/j.annepidem.2011.07.004

[39]

Friedman "Social relationships, sleep quality, and interleukin-6 in aging women" Proc Natl Acad Sci U S A (2005) 10.1073/pnas.0509281102

[40]

Heffner "Chronic low back pain, sleep disturbance, and interleukin-6" Clin J Pain (2011) 10.1097/ajp.0b013e3181eef761

[41]

Heffner "Sleep disturbance and older adults’ inflammatory responses to acute stress" Am J Geriatr Psychiatry (2012) 10.1097/jgp.0b013e31824361de

[42]

Okun "Disturbed sleep is associated with increased C-reactive protein in young women" Brain Behav Immun (2009) 10.1016/j.bbi.2008.10.008

[43]

Okun "Sleep disturbances increase interleukin-6 production during pregnancy: Implications for pregnancy complications" Reprod Sci (2007) 10.1177/1933719107307647

[44]

Prather "Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production" Biol Psychol (2009) 10.1016/j.biopsycho.2009.04.008

[45]

Suarez "Self-reported symptoms of sleep disturbance and inflammation, coagulation, insulin resistance and psychosocial distress: Evidence for gender disparity" Brain Behav Immun (2008) 10.1016/j.bbi.2008.01.011

[46]

Valentine "The associations of adiposity, physical activity and inflammation with fatigue in older adults" Brain Behav Immun (2011) 10.1016/j.bbi.2011.06.002

[47]

van Mark "The impact of shift work induced chronic circadian disruption on IL-6 and TNF-alpha immune responses" J Occup Med Toxicol (2010) 10.1186/1745-6673-5-18

[48]

von Kanel "Sleep and biomarkers of atherosclerosis in elderly Alzheimer caregivers and controls" Gerontology (2010) 10.1159/000264654

[49]

Afshar "Effects of intradialytic aerobic training on sleep quality in hemodialysis patients" Iran J Kidney Dis (2011)

[50]

Bornivelli "Relation between insomnia mood disorders and clinical and biochemical parameters in patients undergoing chronic hemodialysis" J Nephrol (2008)

Showing 50 of 126 references

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References

Details

Published: Jul 01, 2016
Vol/Issue: 80(1)
Pages: 40-52
License: View

Authors

Funding

National Institutes of Health Award: Grant Nos. R01-CA119159

National Institute on Aging Award: R01-AG034588

Cite This Article

Michael R. Irwin, Richard Olmstead, Judith E. Carroll (2016). Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation. Biological Psychiatry, 80(1), 40-52. https://doi.org/10.1016/j.biopsych.2015.05.014

Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation

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