journal article Jul 01, 2020

Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

Cancer Letters Vol. 483 pp. 127-136 · Elsevier BV
View at Publisher Save 10.1016/j.canlet.2020.02.015
Topics

No keywords indexed for this article. Browse by subject →

References
99
[1]
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al.

Cell 2012 10.1016/j.cell.2012.03.042
[2]
Dixon "The role of iron and reactive oxygen species in cell death" Nat. Chem. Biol. (2014) 10.1038/nchembio.1416
[3]
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

Sonam Dolma, Stephen L Lessnick, William C Hahn et al.

Cancer Cell 2003 10.1016/s1535-6108(03)00050-3
[4]
Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

Wan Seok Yang, Brent R. Stockwell

Chemistry & Biology 2008 10.1016/j.chembiol.2008.02.010
[5]
Ferroptosis: process and function

Y Xie, W Hou, X Song et al.

Cell Death & Differentiation 2016 10.1038/cdd.2015.158
[6]
Mechanisms of ferroptosis

Jennifer Yinuo Cao, Scott J. Dixon

Experientia 2016 10.1007/s00018-016-2194-1
[7]
Bridges "System xc(-) cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS" Br. J. Pharmacol. (2012) 10.1111/j.1476-5381.2011.01480.x
[8]
Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang, Rohitha SriRamaratnam, Matthew E. Welsch et al.

Cell 2014 10.1016/j.cell.2013.12.010
[9]
Gkouvatsos "Regulation of iron transport and the role of transferrin" Biochim. Biophys. Acta (2012) 10.1016/j.bbagen.2011.10.013
[10]
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Scott J Dixon, Darpan N Patel, Matthew Welsch et al.

eLife 2014 10.7554/elife.02523
[11]
Cloning and Expression of a Plasma Membrane Cystine/Glutamate Exchange Transporter Composed of Two Distinct Proteins

Hideyo Sato, Michiko Tamba, Tetsuro Ishii et al.

Journal of Biological Chemistry 1999 10.1074/jbc.274.17.11455
[12]
Stabler "Elevation of serum cystathionine levels in patients with cobalamin and folate-deficiency" Blood (1993) 10.1182/blood.v81.12.3404.3404
[14]
Edinger "Antigen-presenting cells control T cell proliferation by regulating amino acid availability" Proc. Natl. Acad. Sci. U. S. A. (2002) 10.1073/pnas.042707999
[15]
Ursini "Purification from pig-liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione-peroxidase activity on phosphatidylcholine hydroperoxides" Biochim. Biophys. Acta (1982) 10.1016/0005-2760(82)90150-3
[16]
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Wan Seok Yang, Kyoungtae Kim, Michael M. Gaschler et al.

Proceedings of the National Academy of Sciences 2016 10.1073/pnas.1603244113
[17]
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E Kagan, Gaowei Mao, Feng Qu et al.

Nature Methods 2017 10.1038/nchembio.2238
[18]
Latunde-Dada "Ferroptosis: role of lipid peroxidation, iron and ferritinophagy" Biochim. Biophys. Acta Gen. Subj. (2017) 10.1016/j.bbagen.2017.05.019
[19]
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll, Bettina Proneth, Yulia Y Tyurina et al.

Nature Methods 2017 10.1038/nchembio.2239
[20]
Cheng "What is responsible for the initiating chemistry of iron-mediated lipid peroxidation: an update (vol 107, pg 748, 2007)" Chem. Rev. (2007) 10.1021/cr040077w
[21]
Ferroptosis: Death by Lipid Peroxidation

Wan Seok Yang, Brent R. Stockwell

Trends in Cell Biology 2016 10.1016/j.tcb.2015.10.014
[22]
Conrad "Regulation of lipid peroxidation and ferroptosis in diverse species" Genes Dev. (2018) 10.1101/gad.314674.118
[23]
Asano "Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells" Mol. Cell Biol. (2011) 10.1128/mcb.01437-10
[24]
Gao "Glutaminolysis and transferrin regulate ferroptosis" Mol. Cell. (2015) 10.1016/j.molcel.2015.06.011
[25]
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al.

Cell 2012 10.1016/j.cell.2012.03.042
[26]
Ma "Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells" PloS One (2017) 10.1371/journal.pone.0182921
[27]
Gao "Cellular iron metabolism and regulation" Adv. Exp. Med. Biol. (2019) 10.1007/978-981-13-9589-5_2
[28]
Haile "Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding" Proc. Natl. Acad. Sci. U. S. A. (1992) 10.1073/pnas.89.24.11735
[29]
Bogdan "Regulators of iron homeostasis: new players in metabolism, cell death, and disease" Trends Biochem. Sci. (2016) 10.1016/j.tibs.2015.11.012
[30]
Reed "Ironing out cell death mechanisms" Cell (2012) 10.1016/j.cell.2012.05.009
[31]
Pantopoulos "Iron metabolism and the IRE/IRP regulatory system: an update" Ann. N. Y. Acad. Sci. (2004) 10.1196/annals.1306.001
[32]
Ferroptosis is an autophagic cell death process

Minghui Gao, Prashant Monian, Qiuhui Pan et al.

Cell Research 2016 10.1038/cr.2016.95
[33]
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Joseph D. Mancias, Xiaoxu Wang, Steven P. Gygi et al.

Nature 2014 10.1038/nature13148
[34]
Autophagy promotes ferroptosis by degradation of ferritin

Wen Hou, Yangchun Xie, Xinxin Song et al.

Autophagy 2016 10.1080/15548627.2016.1187366
[35]
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle, Beat Nyfeler, Jane Nagel et al.

Nature Cell Biology 2014 10.1038/ncb3053
[36]
Lu "The role of ferroptosis in cancer development and treatment response" Front. Pharmacol. (2017) 10.3389/fphar.2017.00992
[37]
Guo "Ferroptosis: a novel anti-tumor action for cisplatin" Canc. Res. Treat. (2018) 10.4143/crt.2016.572
[38]
Ma "Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells" Cell Death Dis. (2016) 10.1038/cddis.2016.208
[39]
Trujillo-Alonso "FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels" Nat. Nanotechnol. (2019) 10.1038/s41565-019-0406-1
[40]
Yamaguchi "Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis" Int. J. Oncol. (2018)
[41]
Sun "Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells" Hepatology (2016) 10.1002/hep.28251
[42]
Klotz "Therapeutic efficacy of sulfasalazine and its metabolites in patients with ulcerative-colitis and crohns-disease" N. Engl. J. Med. (1980) 10.1056/nejm198012253032602
[43]
Wahl "Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B" J. Clin. Invest. (1998) 10.1172/jci992
[44]
Lay "Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL" Canc. Res. (2007) 10.1158/0008-5472.can-06-3191
[45]
Narang "Sulfasalazine-induced reduction of glutathione levels in breast cancer cells: enhancement of growth-inhibitory activity of Doxorubicin" Chemotherapy (2007) 10.1159/000100812
[46]
Guan "The x (c) (-) cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine" Canc. Chemother. Pharmacol. (2009) 10.1007/s00280-008-0894-4
[47]
Okazaki "Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells" Oncotarget (2018) 10.18632/oncotarget.26112
[48]
Sakitama "Effects of a new centrally acting muscle relaxant, NK433 (lanperisone hydrochloride) on spinal reflexes" Eur. J. Pharmacol. (1997) 10.1016/s0014-2999(97)01289-2
[49]
Shaw "Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress" Proc. Natl. Acad. Sci. U. S. A. (2011) 10.1073/pnas.1105941108
[50]
Massey "Acetaminophen-induced hypothermia in mice - evidence for a central action of the parent compound" Toxicology (1982) 10.1016/0300-483x(82)90029-4

Showing 50 of 99 references

Cited By
524
Metrics
524
Citations
99
References
Details
Published
Jul 01, 2020
Vol/Issue
483
Pages
127-136
License
View
Funding
National Natural Science Foundation of China
Natural Science Foundation of Shaanxi Province
Cite This Article
Yanwei Su, Bin Zhao, Liangfu Zhou, et al. (2020). Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs. Cancer Letters, 483, 127-136. https://doi.org/10.1016/j.canlet.2020.02.015