Transforming the Promise of Pluripotent Stem Cell-Derived Cardiomyocytes to a Therapy: Challenges and Solutions for Clinical Trials

Andrew B.J. Prowse; Nicholas E. Timmins; Terrence M. Yau; Ren-Ke Li; Richard D. Weisel; Gordon Keller; Peter W. Zandstra

doi:10.1016/j.cjca.2014.08.005

journal article Nov 01, 2014

Transforming the Promise of Pluripotent Stem Cell-Derived Cardiomyocytes to a Therapy: Challenges and Solutions for Clinical Trials

Andrew B.J. Prowse Nicholas E. Timmins Terrence M. Yau Ren-Ke Li Richard D. Weisel Gordon Keller Peter W. Zandstra

Canadian Journal of Cardiology Vol. 30 No. 11 pp. 1335-1349 · Elsevier BV

View at Publisher Save 10.1016/j.cjca.2014.08.005

Topics

No keywords indexed for this article. Browse by subject →

References

113

[1]

Embryonic Stem Cell Lines Derived from Human Blastocysts

James A. Thomson, Joseph Itskovitz-Eldor, Sander S. Shapiro et al.

Science 1998 10.1126/science.282.5391.1145

[2]

Menasché "Stem cell therapy for chronic heart failure: lessons from a 15-year experience" C R Biol (2011) 10.1016/j.crvi.2011.03.006

[3]

Li "Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells" J Am Coll Cardiol (2012) 10.1016/j.jacc.2011.11.029

[4]

Hamdi "Long-term functional benefits of epicardial patches as cell carriers" Cell Transplant (2014) 10.3727/096368912x658836

[5]

Pagani "Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation" J Am Coll Cardiol (2003) 10.1016/s0735-1097(03)00081-0

[6]

Mirotsou "Paracrine mechanisms of stem cell reparative and regenerative actions in the heart" J Mol Cell Cardiol (2011) 10.1016/j.yjmcc.2010.08.005

[7]

Jeevanantham "Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysis" Circulation (2012) 10.1161/circulationaha.111.086074

[8]

Roger "Heart disease and stroke statistics–2011 update: a report from the American Heart Association" Circulation (2011) 10.1161/cir.0b013e3182009701

[9]

Dickstein Eur Heart J (2008) 10.1093/eurheartj/ehn309

[10]

Stewart "Population impact of heart failure and the most common forms of cancer: a study of 1 162 309 hospital cases in Sweden (1988 to 2004)" Circ Cardiovasc Qual Outcomes (2010) 10.1161/circoutcomes.110.957571

[11]

Left Ventricular Assist Device and Drug Therapy for the Reversal of Heart Failure

Emma J. Birks, Patrick D. Tansley, James Hardy et al.

New England Journal of Medicine 2006 10.1056/nejmoa053063

[12]

Reffelmann "Promise of blood- and bone marrow-derived stem cell transplantation for functional cardiac repair: putting it in perspective with existing therapy" J Am Coll Cardiol (2009) 10.1016/j.jacc.2008.10.018

[13]

Assmus "Clinical outcome 2 years after intracoronary administration of bone marrow-derived progenitor cells in acute myocardial infarction" Circ Heart Fail (2010) 10.1161/circheartfailure.108.843243

[14]

Traverse "Effect of the use and timing of bone marrow mononuclear cell delivery on left ventricular function after acute myocardial infarction: the TIME randomized trial" JAMA (2012) 10.1001/jama.2012.28726

[15]

Comparison of Allogeneic vs Autologous Bone Marrow–Derived Mesenchymal Stem Cells Delivered by Transendocardial Injection in Patients With Ischemic Cardiomyopathy

Joshua M. Hare, Joel E. Fishman, Gary Gerstenblith et al.

JAMA 2012 10.1001/jama.2012.25321

[16]

Bolli "Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial" Lancet (2011) 10.1016/s0140-6736(11)61590-0

[17]

Makkar "Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial" Lancet (2012) 10.1016/s0140-6736(12)60195-0

[18]

Williams "Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease" Circ Res (2011) 10.1161/circresaha.111.243147

[19]

Loffredo "Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair" Cell Stem Cell (2011) 10.1016/j.stem.2011.02.002

[20]

Garbern "Cardiac stem cell therapy and the promise of heart regeneration" Cell Stem Cell (2013) 10.1016/j.stem.2013.05.008

[21]

Mummery "Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview" Circ Res (2012) 10.1161/circresaha.110.227512

[22]

Burridge "Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming" Cell Stem Cell (2012) 10.1016/j.stem.2011.12.013

[23]

Yang "Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population" Nature (2008) 10.1038/nature06894

[24]

Elliott "NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes" Nat Methods (2011) 10.1038/nmeth.1740

[25]

Kattman "Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines" Cell Stem Cell (2011) 10.1016/j.stem.2010.12.008

[26]

Lian "Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions" Nat Protoc (2013) 10.1038/nprot.2012.150

[27]

Lian "Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling" Proc Natl Acad Sci U S A (2012) 10.1073/pnas.1200250109

[28]

Ren "Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells" J Mol Cell Cardiol (2011) 10.1016/j.yjmcc.2011.04.012

[29]

Bondue "Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification" Cell Stem Cell (2008) 10.1016/j.stem.2008.06.009

[30]

David "Induction of MesP1 by Brachyury(T) generates the common multipotent cardiovascular stem cell" Cardiovasc Res (2011) 10.1093/cvr/cvr158

[31]

Costello "The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation" Nat Cell Biol (2011) 10.1038/ncb2304

[32]

David "MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling" Nat Cell Biol (2008) 10.1038/ncb1696

[33]

Osafune "Marked differences in differentiation propensity among human embryonic stem cell lines" Nat Biotechnol (2008) 10.1038/nbt1383

[34]

Burridge "Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability" Stem Cells (2007) 10.1634/stemcells.2006-0598

[35]

Stefanovic "Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate" J Cell Biol (2009) 10.1083/jcb.200901040

[36]

Gafni "Derivation of novel human ground state naive pluripotent stem cells" Nature (2013) 10.1038/nature12745

[37]

Zhang "Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method" Circ Res (2012) 10.1161/circresaha.112.273144

[38]

Blin "A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates" J Clin Invest (2010) 10.1172/jci40120

[39]

Hentze "Teratoma formation by human embryonic stem cells: evaluation of essential parameters for future safety studies" Stem Cell Res (2009) 10.1016/j.scr.2009.02.002

[40]

He "Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization" Circ Res (2003) 10.1161/01.res.0000080317.92718.99

[41]

Ma "High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents" Am J Physiol Heart Circ Physiol (2011) 10.1152/ajpheart.00694.2011

[42]

Chen "Electrophysiological challenges of cell-based myocardial repair" Circulation (2009) 10.1161/circulationaha.107.751412

[43]

Gepstein "In vivo assessment of the electrophysiological integration and arrhythmogenic risk of myocardial cell transplantation strategies" Stem Cells (2010) 10.1002/stem.545

[44]

Evseenko "Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells" Proc Natl Acad Sci U S A (2010) 10.1073/pnas.1002077107

[45]

Bizy "Myosin light chain 2-based selection of human iPSC-derived early ventricular cardiac myocytes" Stem Cell Res (2013) 10.1016/j.scr.2013.09.003

[46]

Uosaki "Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression" PLoS One (2011) 10.1371/journal.pone.0023657

[47]

Dubois "SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells" Nat Biotechnol (2011) 10.1038/nbt.2005

[48]

Tohyama "Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes" Cell Stem Cell (2013) 10.1016/j.stem.2012.09.013

[49]

Hattori "Nongenetic method for purifying stem cell-derived cardiomyocytes" Nat Methods (2010) 10.1038/nmeth.1403

[50]

Huber "Identification and selection of cardiomyocytes during human embryonic stem cell differentiation" FASEB J (2007) 10.1096/fj.05-5711com

Showing 50 of 113 references

Metrics

20

Citations

113

References

Details

Published: Nov 01, 2014
Vol/Issue: 30(11)
Pages: 1335-1349
License: View

Authors

Cite This Article

Andrew B.J. Prowse, Nicholas E. Timmins, Terrence M. Yau, et al. (2014). Transforming the Promise of Pluripotent Stem Cell-Derived Cardiomyocytes to a Therapy: Challenges and Solutions for Clinical Trials. Canadian Journal of Cardiology, 30(11), 1335-1349. https://doi.org/10.1016/j.cjca.2014.08.005

Transforming the Promise of Pluripotent Stem Cell-Derived Cardiomyocytes to a Therapy: Challenges and Solutions for Clinical Trials

You May Also Like