The Interplay Between Titin, Polygenic Risk, and Modifiable Cardiovascular Risk Factors in Atrial Fibrillation

KATE HUANG; Mark Trinder; Thomas M. Roston; Zachary W. Laksman; Liam R. Brunham

doi:10.1016/j.cjca.2020.12.024

journal article Jun 01, 2021

The Interplay Between Titin, Polygenic Risk, and Modifiable Cardiovascular Risk Factors in Atrial Fibrillation

KATE HUANG Mark Trinder Thomas M. Roston Zachary W. Laksman Liam R. Brunham

Canadian Journal of Cardiology Vol. 37 No. 6 pp. 848-856 · Elsevier BV

View at Publisher Save 10.1016/j.cjca.2020.12.024

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References

30

[1]

Chugh "Worldwide epidemiology of atrial fibrillation: a global burden of disease 2010 study" Circulation (2014) 10.1161/circulationaha.113.005119

[2]

Thrall "Quality of life in patients with atrial fibrillation: a systematic review" Am J Med (2006) 10.1016/j.amjmed.2005.10.057

[3]

Marini "Contribution of atrial fibrillation to incidence and outcome of ischemic stroke: results from a population-based study" Stroke (2005) 10.1161/01.str.0000166053.83476.4a

[4]

Stewart "A population-based study of the long-term risks associated with atrial fibrillation: 20-year follow-up of the Renfrew/Paisley Study" Am J Med (2002) 10.1016/s0002-9343(02)01236-6

[5]

The Burden of Atrial Fibrillation on the Hospital Sector in Canada

Daria J. O'Reilly, Robert B. Hopkins, Jeff S. Healey et al.

Canadian Journal of Cardiology 2013 10.1016/j.cjca.2012.03.023

[6]

Roselli "Multi-ethnic genome-wide association study for atrial fibrillation" Nat Genet (2018) 10.1038/s41588-018-0133-9

[7]

Nielsen "Biobank-driven genomic discovery yields new insight into atrial fibrillation biology" Nat Genet (2018) 10.1038/s41588-018-0171-3

[8]

Ahlberg "Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation" Nat Commun (2018) 10.1038/s41467-018-06618-y

[9]

Choi "Association between titin loss-of-function variants and early-onset atrial fibrillation" JAMA (2018) 10.1001/jama.2018.18179

[10]

Pirruccello "Titin truncating variants in adults without known congestive heart failure" J Am Coll Cardiol (2020) 10.1016/j.jacc.2020.01.013

[11]

Benjamin "Independent risk factors for atrial fibrillation in a population-based cohort: the Framingham Heart Study" JAMA (1994) 10.1001/jama.1994.03510350050036

[12]

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

Amit V. Khera, Mark Chaffin, Krishna G. Aragam et al.

Nature Genetics 2018 10.1038/s41588-018-0183-z

[13]

Weng "Genetic predisposition, clinical risk factor burden, and lifetime risk of atrial fibrillation" Circulation (2018) 10.1161/circulationaha.117.031431

[14]

The UK Biobank resource with deep phenotyping and genomic data

Clare Bycroft, Colin Freeman, Desislava Petkova et al.

Nature 2018 10.1038/s41586-018-0579-z

[15]

van Hout "Exome sequencing and characterization of 49,960 individuals in the UK Biobank" Nature (2020) 10.1038/s41586-020-2853-0

[16]

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

Pablo Cingolani, Adrian Platts, Le Lily Wang et al.

Fly 2012 10.4161/fly.19695

[17]

Liu "dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions" Hum Mutat (2011) 10.1002/humu.21517

[18]

Liu "dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice-site SNVs" Hum Mutat (2016) 10.1002/humu.22932

[19]

ClinVar: public archive of relationships among sequence variation and human phenotype

Melissa J. Landrum, Jennifer M. Lee, George R. Riley et al.

Nucleic Acids Research 2014 10.1093/nar/gkt1113

[20]

Cingolani "Using Drosophila melanogaster as a model for genotoxic chemical mutational studies with a new program" SnpSift. Front Genet (2012)

[21]

Roberts "Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease" Sci Transl Med (2015) 10.1126/scitranslmed.3010134

[22]

Second-generation PLINK: rising to the challenge of larger and richer datasets

Christopher C Chang, Carson C Chow, Laurent CAM Tellier et al.

Gigascience 2015 10.1186/s13742-015-0047-8

[23]

Corden "Association of titin-truncating genetic variants with life-threatening cardiac arrhythmias in patients with dilated cardiomyopathy and implanted defibrillators" JAMA Netw Open (2019) 10.1001/jamanetworkopen.2019.6520

[24]

van den Ham "Comparative Performance of ATRIA, CHADS2, and CHA2DS2-VASc risk scores predicting stroke in patients with atrial fibrillation" J Am Coll Cardiol (2015) 10.1016/j.jacc.2015.08.033

[25]

Aspberg "Comparison of the ATRIA, CHADS2, and CHA2DS2-VASc stroke risk scores in predicting ischaemic stroke in a large Swedish cohort of patients with atrial fibrillation" Eur Heart J (2016) 10.1093/eurheartj/ehw077

[26]

Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population

Anna Fry, Thomas J Littlejohns, Cathie Sudlow et al.

American Journal of Epidemiology 2017 10.1093/aje/kwx246

[27]

Chung "Lifestyle and risk factor modification for reduction of atrial fibrillation: a scientific statement from the American Heart Association" Circulation (2020) 10.1161/cir.0000000000000748

[28]

Gami "Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation" J Am Coll Cardiol (2007) 10.1016/j.jacc.2006.08.060

[29]

Nalliah "The role of obesity in atrial fibrillation" Eur Heart J (2016) 10.1093/eurheartj/ehv486

[30]

Chamberlain "Smoking and incidence of atrial fibrillation: results from the Atherosclerosis Risk in Communities (ARIC) study" Heart Rhythm (2011) 10.1016/j.hrthm.2011.03.038

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References

Details

Published: Jun 01, 2021
Vol/Issue: 37(6)
Pages: 848-856
License: View

Authors

Centre for Heart Lung Innovation, The University of British Columbia, Vancouver, British Columbia, Canada; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard, Cambridge, Massachusetts

Funding

Compute Canada

Michael Smith Foundation for Health Research

University of British Columbia

Cite This Article

KATE HUANG, Mark Trinder, Thomas M. Roston, et al. (2021). The Interplay Between Titin, Polygenic Risk, and Modifiable Cardiovascular Risk Factors in Atrial Fibrillation. Canadian Journal of Cardiology, 37(6), 848-856. https://doi.org/10.1016/j.cjca.2020.12.024

The Interplay Between Titin, Polygenic Risk, and Modifiable Cardiovascular Risk Factors in Atrial Fibrillation

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