journal article Open Access Jun 01, 2026

PFOA, PFOS, PFBA, PFBS, ADONA and GenX: Toxicological profile for freshwater ecosystems

Cleaner Water Vol. 6 pp. 100259 · Elsevier BV
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References
70
[1]
Ankley "Assessing the ecological risks of per- and polyfluoroalkyl substances: current state-of-the science and a proposed path forward" Environ. Toxicol. Chem. (2021) 10.1002/etc.4869
[2]
Antić "Integrated targeted and suspect screening workflow for identifying PFAS of concern in urban-impacted Serbian Rivers" Toxics (2026) 10.3390/toxics14010078
[3]
The overlooked short- and ultrashort-chain poly- and perfluorinated substances: A review

Mohamed Ateia, Amith Maroli, Nishanth Tharayil et al.

Chemosphere 2019 10.1016/j.chemosphere.2018.12.186
[4]
Balgooyen "Historical PFAS trends in the Great Lakes using four decades of archived fish" J. Gt. Lakes Res. (2026) 10.1016/j.jglr.2026.102741
[5]
Banyoi "The effects of exposure to environmentally relevant PFAS concentrations for aquatic organisms at different consumer trophic levels: systematic review and meta-analyses" Environ. Pollut. (2022) 10.1016/j.envpol.2022.120422
[6]
Bertanza "Long-term investigation on the removal of perfluoroalkyl substances in a full-scale drinking water treatment plant in the Veneto Region, Italy" Sci. Total Environ. (2020) 10.1016/j.scitotenv.2020.139154
[7]
Brusseau "The influence of surfactant and solution composition on PFAS adsorption at fluid-fluid interfaces" Water Res (2019) 10.1016/j.watres.2019.05.095
[8]
Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins

Robert C Buck, James Franklin, Urs Berger et al.

Integrated Environmental Assessment and Management 2011 10.1002/ieam.258
[9]
Casella "Comprehensive review of per- and polyfluoroalkyl substances (PFAS) in groundwater: occurrence, ecological impacts, analytical techniques, and remediation strategies" J. Water Process Eng. (2025) 10.1016/j.jwpe.2025.108391
[10]
Chang "Risk prioritization and experimental validation of per- and polyfluoroalkyl substances (PFAS) in Chaohu Lake: based on nontarget and target analyses" J. Hazard. Mater. (2025) 10.1016/j.jhazmat.2025.138179
[11]
Chiriac "Perfluoroalkyl acids and perfluorooctane sulfonate in the Romanian Black Sea: occurrence and risk assessment" Microchem. J. (2026) 10.1016/j.microc.2026.117767
[12]
PFAS Contamination in Europe: Generating Knowledge and Mapping Known and Likely Contamination with “Expert-Reviewed” Journalism

Alissa Cordner, Phil Brown, Ian T. Cousins et al.

Environmental Science & Technology 2024 10.1021/acs.est.3c09746
[13]
Cordner "Regrettable for whom? GenX chemicals as a case study in detrimental chemical substitution" Environ. Sci. Policy (2025) 10.1016/j.envsci.2025.104262
[14]
D’Ambro "Predictions of PFAS regional-scale atmospheric deposition and ambient air exposure" Sci. Total Environ. (2023)
[15]
Dai "Biotransformation of per- and polyfluoroalkyl substances (PFAS) in organisms" Chem. Eng. J. (2025) 10.1016/j.cej.2025.168618
[16]
De Voogt "Analytical chemistry of perfluoroalkylated substances" TrAC - Trends Anal. Chem. (2006) 10.1016/j.trac.2005.10.008
[17]
A review of recent studies on toxicity, sequestration, and degradation of per- and polyfluoroalkyl substances (PFAS)

Rebecca A. Dickman, Diana S. Aga

Journal of Hazardous Materials 2022 10.1016/j.jhazmat.2022.129120
[18]
Ding "Toxicity of polyfluorinated and perfluorinated compounds to lettuce (Lactuca sativa) and green algae (Pseudokirchneriella subcapitata)" Arch. Environ. Contam. Toxicol. (2012) 10.1007/s00244-011-9684-9
[19]
Directive 2020/2184/EU, 2020. Directive (EU) 2020/2184 of the European Parliament and of the Council of 16 December 2020 on the quality of water intended for human consumption. Official Journal of the European Union 2019.
[20]
Duru "Per- and polyfluoroalkyl substance (PFAS) occurrence in gunpowder river watershed in Maryland United States" Water (Basel) (2026)
[21]
ECHA CHEM, 2022. ECHA Chemicals Database [WWW Document].
[22]
Biomagnification and potential health effects of per- and polyfluoroalkyl substances (PFAS) in a terrestrial food web

Frauke Ecke, Bjørnar Ytrehus, Magnus Evander et al.

Scientific Reports 2025 10.1038/s41598-025-16395-6
[23]
Ehsan "Per- and polyfluoroalkyl substances in aquatic sediments: global distribution, partitioning behavior, and ecological consequences" J. Environ. Qual. (2026) 10.1002/jeq2.70148
[24]
EU Commission "Proposal for a directive of the European parliament and of the Council amending Directive 2000/60/EC establishing a framework for Community action in the field of water policy" Off. J. Eur. Communities 0344. (2025)
[25]
Evich "Per- and polyfluoroalkyl substances in the environment" Science (2022)
[26]
PFAS on atmospheric aerosol particles: a review

Jennifer A. Faust

Environmental Science: Processes & Impacts 2023 10.1039/d2em00002d
[27]
Fitzgerald "Perfluoroalkyl substances increase the membrane permeability and quorum sensing response in aliivibrio fischeri" Environ. Sci. Technol. Lett. (2018) 10.1021/acs.estlett.7b00518
[28]
An overview of the uses of per- and polyfluoroalkyl substances (PFAS)

Juliane Glüge, Martin Scheringer, Ian T. Cousins et al.

Environmental Science: Processes & Impacts 2020 10.1039/d0em00291g
[29]
Guidance on PFAS Exposure "Testing, and clinical follow-up" Guid. PFAS Expo. Test. Clin. Follow- (2022)
[30]
The untold story of PFAS alternatives: Insights into the occurrence, ecotoxicological impacts, and removal strategies in the aquatic environment

Naima Hamid, Muhammad Junaid, Marriya Sultan et al.

Water Research 2024 10.1016/j.watres.2023.121044
[31]
Jeong "Multigenerational effect of perfluorooctane sulfonate (PFOS) on the individual fitness and population growth of Daphnia magna" Sci. Total Environ. 569570 (2016) 10.1016/j.scitotenv.2016.06.249
[32]
Kaltenberg "Sampling of freely dissolved per- and polyfluoroalkyl substances (PFAS) in surface water and groundwater using a newly developed passive sampler" Environ. Pollut. (2023) 10.1016/j.envpol.2022.120940
[33]
Labine "Sublethal exposure of per- and polyfluoroalkyl substances of varying chain length and polar functionality results in distinct metabolic responses in daphnia magna" Environ. Toxicol. Chem. (2023) 10.1002/etc.5517
[34]
LaFond "Bacterial transformation of per- and poly-fluoroalkyl substances: a review for the field of bioremediation" Environmental Science Advances (2023) 10.1039/d3va00031a
[35]
Lee "Distribution and concentration of airborne per- and polyfluoroalkyl substances (PFAS) in indoor and outdoor environments: a systematic review" Saf. Health Work (2026) 10.1016/j.shaw.2026.01.002
[36]
Li "Determination of legacy and emerging per- and polyfluoroalkyl substances (PFAS) in indoor and outdoor air" ACS ES&T Air (2024) 10.1021/acsestair.4c00095
[37]
Liang "Effects of perfluorooctane sulfonate on immobilization, heartbeat, reproductive and biochemical performance of Daphnia magna" Chemosphere (2017) 10.1016/j.chemosphere.2016.11.147
[38]
Liu "Toxic effect of serial perfluorosulfonic and perfluorocarboxylic acids on the membrane system of a freshwater alga measured by flow cytometry" Environ. Toxicol. Chem. (2008) 10.1897/07-459.1
[39]
Liu "Perfluoroalkyl and polyfluoroalkyl substances (PFAS) in the Yangtze River: distribution, transport, and influencing factors" ACS ES&T Water (2026) 10.1021/acsestwater.5c01014
[40]
Toxicity of Per- and Polyfluoroalkyl Substances to Aquatic Invertebrates, Planktons, and Microorganisms

Tingting Ma, Chaoran Ye, Tiantian Wang et al.

International Journal of Environmental Research an... 2022 10.3390/ijerph192416729
[41]
Miranda "A worldwide evaluation of trophic magnification of per- and polyfluoroalkyl substances in aquatic ecosystems" Integr. Environ. Assess. Manag (2022) 10.1002/ieam.4579
[42]
NORMAN Network, n.d. NORMAN Network: Monitoring, assessment and management of emerging substances [WWW Document]. 2025. URL 〈https://www.norman-network.com/〉 (accessed 11.20.25).
[43]
OECD "Reconciling terminology of the universe of per- and polyfluoroalkyl substances: recommendations and practical guidance" OECD Ser. Risk Manag. - No. 61 (2021)
[44]
Poulsen, P.B., Jensen, A.A., Wallström, E., Aps, E., 2005. More environmentally friendly alternatives to PFOS-compounds and PFOA.
[45]
Sources, Fate and Transport of Perfluorocarboxylates

Konstantinos Prevedouros, Ian T. Cousins, Robert C. Buck et al.

Environmental Science & Technology 2006 10.1021/es0512475
[46]
Rahman, M.F., Peldszus, S., Anderson, W.B., 2013. ScienceDirect Behaviour and fate of perfluoroalkyl and polyfluoroalkyl substances ( PFASs) in drinking water treatment: A review 0. https://doi.org/10.1016/j.watres.2013.10.045. 10.1016/j.watres.2013.10.045
[47]
Seyoum "Perfluorinated alkyl substances impede growth, reproduction, lipid metabolism and lifespan in Daphnia magna" Sci. Total Environ. (2020) 10.1016/j.scitotenv.2020.139682
[48]
Challenges and Current Status of the Biological Treatment of PFAS-Contaminated Soils

Esmaeil Shahsavari, Duncan Rouch, Leadin S. Khudur et al.

Frontiers in Bioengineering and Biotechnology 2021 10.3389/fbioe.2020.602040
[49]
Shen "Trends in the analysis and exploration of per- and polyfluoroalkyl substances (PFAS) in environmental matrices: a review" Crit. Rev. Anal. Chem. (2023)
[50]
Sobolewski "Aggregation, not micellization: perfluorooctanoic acid, perfluorobutanesulfonic acid, and potassium perfluorooctanesulfonate behavior in aqueous solution" Langmuir (2024) 10.1021/acs.langmuir.4c02566

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Published
Jun 01, 2026
Vol/Issue
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100259
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Cite This Article
Michele Menghini, Giorgio Bertanza, Marta Marcandelli, et al. (2026). PFOA, PFOS, PFBA, PFBS, ADONA and GenX: Toxicological profile for freshwater ecosystems. Cleaner Water, 6, 100259. https://doi.org/10.1016/j.clwat.2026.100259