Phloretin-induced modulation in gut microbiome, mitigates colonic inflammation and alleviates colitis-associated colorectal cancer in mice

Smita Kapoor; Priyanka Mehta; Vikram Patial; Rajesh Pandey; Yogendra S. Padwad

doi:10.1016/j.csbj.2025.06.016

journal article Open Access Jan 01, 2025

Phloretin-induced modulation in gut microbiome, mitigates colonic inflammation and alleviates colitis-associated colorectal cancer in mice

Smita Kapoor Priyanka Mehta

Vikram Patial

Rajesh Pandey Yogendra S. Padwad

Computational and Structural Biotechnology Journal Vol. 27 pp. 2730-2746 · American Association for the Advancement of Science (AAAS)

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Published: Jan 01, 2025
Vol/Issue: 27
Pages: 2730-2746
License: View

Authors

S

Smita Kapoor

Pharmacology and Toxicology Lab, Dietetics & Nutrition Technology Division, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, Himachal Pradesh 176061, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

P

Priyanka Mehta

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; Division of Immunology and Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi 110007, India

V

Vikram Patial

Pharmacology and Toxicology Lab, Dietetics & Nutrition Technology Division, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, Himachal Pradesh 176061, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

R

Rajesh Pandey

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; Division of Immunology and Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi 110007, India

Y

Yogendra S. Padwad

Pharmacology and Toxicology Lab, Dietetics & Nutrition Technology Division, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, Himachal Pradesh 176061, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

Funding

Bill and Melinda Gates Foundation Award: INV-033578

Council of Scientific and Industrial Research, India Award: MLP0204

Cite This Article

Smita Kapoor, Priyanka Mehta, Vikram Patial, et al. (2025). Phloretin-induced modulation in gut microbiome, mitigates colonic inflammation and alleviates colitis-associated colorectal cancer in mice. Computational and Structural Biotechnology Journal, 27, 2730-2746. https://doi.org/10.1016/j.csbj.2025.06.016

Phloretin-induced modulation in gut microbiome, mitigates colonic inflammation and alleviates colitis-associated colorectal cancer in mice

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