journal article Open Access Jun 01, 2008

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

Developmental Cell Vol. 14 No. 6 pp. 818-829 · Elsevier BV
View at Publisher Save 10.1016/j.devcel.2008.05.009
Topics

No keywords indexed for this article. Browse by subject →

References
116
[1]
Ahmed "Mechanisms of palatal epithelial seam disintegration by transforming growth factor (TGF) β3" Dev. Biol. (2007) 10.1016/j.ydbio.2007.06.018
[2]
Aigner "The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity" Oncogene (2007) 10.1038/sj.onc.1210508
[3]
Ayyanathan "The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling" Cancer Res. (2007) 10.1158/0008-5472.can-07-2987
[4]
Bachelder "Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition" J. Cell Biol. (2005) 10.1083/jcb.200409067
[5]
Barrios-Rodiles "High-throughput mapping of a dynamic signaling network in mammalian cells" Science (2005) 10.1126/science.1105776
[6]
The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

Eduard Batlle, Elena Sancho, Clara Francí et al.

Nature Cell Biology 2000 10.1038/35000034
[7]
Birchmeier "Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells" Ciba Found. Symp. (1997)
[8]
Bolender "Epithelial-mesenchymal transformation in chick atrioventricular cushion morphogenesis" Scan. Electron Microsc. (1979)
[9]
Boyer "TGFβ2 and TGFβ3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart" Dev. Biol. (1999) 10.1006/dbio.1999.9211
[10]
Boyer "Epithelium-mesenchyme interconversion as example of epithelial plasticity" APMIS (1993) 10.1111/j.1699-0463.1993.tb00109.x
[11]
Boyer "Src and Ras are involved in separate pathways in epithelial cell scattering" EMBO J. (1997) 10.1093/emboj/16.19.5904
[12]
Bukholm "E-cadherin and α-, β-, and γ-catenin protein expression in relation to metastasis in human breast carcinoma" J. Pathol. (1998) 10.1002/(sici)1096-9896(199807)185:3<262::aid-path97>3.0.co;2-y
[13]
Bukholm "Re-expression of E-cadherin, α-catenin and β-catenin, but not of γ-catenin, in metastatic tissue from breast cancer patients" J. Pathol. (2000) 10.1002/(sici)1096-9896(200001)190:1<15::aid-path489>3.0.co;2-l
[14]
Camenisch "Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors" Nat. Med. (2002) 10.1038/nm742
[15]
The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

Amparo Cano, Mirna A. Pérez-Moreno, Isabel Rodrigo et al.

Nature Cell Biology 2000 10.1038/35000025
[16]
Carver "The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition" Mol. Cell. Biol. (2001) 10.1128/mcb.21.23.8184-8188.2001
[17]
Chen "The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo" Development (2006) 10.1242/dev.02210
[18]
Chen "twist is required in head mesenchyme for cranial neural tube morphogenesis" Genes Dev. (1995) 10.1101/gad.9.6.686
[19]
Ciruna "FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak" Dev. Cell (2001) 10.1016/s1534-5807(01)00017-x
[20]
The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion

Joke Comijn, Geert Berx, Petra Vermassen et al.

Molecular Cell 2001 10.1016/s1097-2765(01)00260-x
[21]
Conacci-Sorrell "Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK" J. Cell Biol. (2003) 10.1083/jcb.200308162
[22]
Cornell "Notch in the pathway: the roles of Notch signaling in neural crest development" Semin. Cell Dev. Biol. (2005) 10.1016/j.semcdb.2005.06.009
[23]
Correia "Bmp2 is required for migration but not for induction of neural crest cells in the mouse" Dev. Dyn. (2007) 10.1002/dvdy.21256
[24]
Davies "Mesenchyme to epithelium transition during development of the mammalian kidney tubule" Acta Anat. (Basel) (1996) 10.1159/000147846
[25]
De Calisto "Essential role of non-canonical Wnt signalling in neural crest migration" Development (2005) 10.1242/dev.01857
[26]
Dietrich "The role of SF/HGF and c-Met in the development of skeletal muscle" Development (1999) 10.1242/dev.126.8.1621
[27]
Duband "Distribution of laminin and collagens during avian neural crest development" Development (1987) 10.1242/dev.101.3.461
[28]
Duband "Epithelium-mesenchyme transition during neural crest development" Acta Anat. (Basel) (1995) 10.1159/000147752
[29]
Eger "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells" Oncogene (2005) 10.1038/sj.onc.1208429
[30]
Fitchett "Medial edge epithelium transforms to mesenchyme after embryonic palatal shelves fuse" Dev. Biol. (1989) 10.1016/s0012-1606(89)80017-x
[31]
Fodde "Wnt/beta-catenin signaling in cancer stemness and malignant behavior" Curr. Opin. Cell Biol. (2007) 10.1016/j.ceb.2007.02.007
[32]
Frixen "E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells" J. Cell Biol. (1991) 10.1083/jcb.113.1.173
[33]
Fujita "Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex" Nat. Cell Biol. (2002) 10.1038/ncb758
[34]
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

Cedric Gaggioli, Steven Hooper, Cristina Hidalgo-Carcedo et al.

Nature Cell Biology 2007 10.1038/ncb1658
[35]
Garcia-Castro "Ectodermal Wnt function as a neural crest inducer" Science (2002) 10.1126/science.1070824
[36]
Ghabrial "Branching morphogenesis of the Drosophila tracheal system" Annu. Rev. Cell Dev. Biol. (2003) 10.1146/annurev.cellbio.19.031403.160043
[37]
Giroldi "Role of E boxes in the repression of E-cadherin expression" Biochem. Biophys. Res. Commun. (1997) 10.1006/bbrc.1997.7831
[38]
Gitelman "Twist protein in mouse embryogenesis" Dev. Biol. (1997) 10.1006/dbio.1997.8614
[39]
Gitler "Molecular markers of cardiac endocardial cushion development" Dev. Dyn. (2003) 10.1002/dvdy.10418
[40]
Greenburg "Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells" J. Cell Biol. (1982) 10.1083/jcb.95.1.333
[41]
Greenburg "Cytodifferentiation and tissue phenotype change during transformation of embryonic lens epithelium to mesenchyme-like cells in vitro" Dev. Biol. (1986) 10.1016/0012-1606(86)90256-3
[42]
Greenburg "Cytoskeleton and thyroglobulin expression change during transformation of thyroid epithelium to mesenchyme-like cells" Development (1988) 10.1242/dev.102.3.605
[43]
Griffith "Epithelial-mesenchymal transformation during palatal fusion: carboxyfluorescein traces cells at light and electron microscopic levels" Development (1992) 10.1242/dev.116.4.1087
[44]
Grunert "Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis" Nat. Rev. Mol. Cell Biol. (2003) 10.1038/nrm1175
[45]
Guilford "E-cadherin germline mutations in familial gastric cancer" Nature (1998) 10.1038/32918
[46]
Hajra "The SLUG zinc-finger protein represses E-cadherin in breast cancer" Cancer Res. (2002)
[47]
Han "Distinct mechanisms of TGF-β1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis" J. Clin. Invest. (2005) 10.1172/jci24399
[48]
Hartwell "The Spemann organizer gene, Goosecoid, promotes tumor metastasis" Proc. Natl. Acad. Sci. USA (2006) 10.1073/pnas.0608636103
[49]
Hay "An overview of epithelio-mesenchymal transformation" Acta Anat. (Basel) (1995) 10.1159/000147748
[50]
Hennig "Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo" Oncogene (1995)

Showing 50 of 116 references

Cited By
2,437
Metrics
2,437
Citations
116
References
Details
Published
Jun 01, 2008
Vol/Issue
14(6)
Pages
818-829
License
View
Funding
National Institutes of Health Award: 1DP2OD002420
Breast Cancer Research Foundation
Sidney Kimmel Foundation for Cancer Research
Ludwig Center for Molecular Oncology
Cite This Article
Jing Yang, Robert A. Weinberg (2008). Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis. Developmental Cell, 14(6), 818-829. https://doi.org/10.1016/j.devcel.2008.05.009
Related

You May Also Like

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

Bryan T. MacDonald, Keiko Tamai · 2009

4,830 citations

Development by Self-Digestion

Beth Levine, Daniel J Klionsky · 2004

3,133 citations

The Diverse Functions of MicroRNAs in Animal Development and Disease

Wigard P. Kloosterman, Ronald H.A. Plasterk · 2006

1,678 citations