journal article May 01, 2025

Dihydrotanshinone I potentiates the anti-tumor activity of cisplatin by activating ROS-mediated ER stress through targeting HSPD1 in lung cancer cells

View at Publisher Save 10.1016/j.ejphar.2025.177378
Topics

No keywords indexed for this article. Browse by subject →

References
50
[1]
Abu-Hadid "Relationship between heat shock protein 60 (HSP60) mRNA expression and resistance to platinum analogues in human ovarian and bladder carcinoma cell lines" Cancer Lett. (1997) 10.1016/s0304-3835(97)00255-3
[2]
Aluksanasuwan "Potential association of HSPD1 with dysregulations in ribosome biogenesis and immune cell infiltration in lung adenocarcinoma: an integrated bioinformatic approach" Cancer Biomarkers : section A of Disease markers (2023) 10.3233/cbm-220442
[3]
Cao "Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020" Chinese medical journal (2021) 10.1097/cm9.0000000000001474
[4]
Chatterjee "Targeting heat shock proteins in cancer: a promising therapeutic approach" Int. J. Mol. Sci. (2017) 10.3390/ijms18091978
[5]
Cheng "Pendulone induces apoptosis via the ROS-mediated ER-stress pathway in human non-small cell lung cancer cells" Toxicol. Vitro : Int. J. Publ. Assoc. BIBRA (2022) 10.1016/j.tiv.2022.105346
[6]
Chuang "15,16-Dihydrotanshinone I, a compound of Salvia miltiorrhiza bunge, induces apoptosis through inducing endoplasmic reticular stress in human prostate carcinoma cells. Evidence-Based complementary and alternative medicine" eCAM (2011)
[7]
Coriat "Sorafenib-induced hepatocellular carcinoma cell death depends on reactive oxygen species production in vitro and in vivo" Mol. Cancer Therapeut. (2012) 10.1158/1535-7163.mct-12-0093
[8]
Cisplatin in cancer therapy: Molecular mechanisms of action

Shaloam Dasari, Paul Bernard Tchounwou

European Journal of Pharmacology 2014 10.1016/j.ejphar.2014.07.025
[9]
Dubrez "Heat-shock proteins: chaperoning DNA repair" Oncogene (2020) 10.1038/s41388-019-1016-y
[10]
Fan "Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo" Cell Death Dis. (2020) 10.1038/s41419-020-2317-3
[11]
Fang "miR-382 contributes to renal tubulointerstitial fibrosis by downregulating HSPD1" Oxid. Med. Cell. Longev. (2017) 10.1155/2017/4708516
[12]
Fennell "Cisplatin in the modern era: the backbone of first-line chemotherapy for non-small cell lung cancer" Cancer Treat Rev. (2016) 10.1016/j.ctrv.2016.01.003
[13]
Fucarino "Role of HSP60/HSP10 in lung cancer: simple biomarkers or leading actors?" J. Oncol. (2020) 10.1155/2020/4701868
[14]
Ge "Toxic effects of Tripterygium glycoside tablets on the reproductive system of male rats by metabolomics, cytotoxicity, and molecular docking" Phytomedicine : Int. J. Phytother. Phytopharmacol. (2023) 10.1016/j.phymed.2023.154813
[15]
Gorrini "Modulation of oxidative stress as an anticancer strategy" Nat. Rev. Drug Discov. (2013) 10.1038/nrd4002
[16]
Groeger "Hydrogen peroxide as a cell-survival signaling molecule" Antioxidants Redox Signal. (2009) 10.1089/ars.2009.2728
[17]
Jiang "HIF-1α preconditioning potentiates antioxidant activity in ischemic injury: the role of sequential administration of dihydrotanshinone I and protocatechuic aldehyde in cardioprotection" Antioxidants Redox Signal. (2019) 10.1089/ars.2018.7624
[18]
Jones "Recent advances in the management of lung cancer" Clin. Med. (London, England) (2018) 10.7861/clinmedicine.18-2-s41
[19]
Kang "HSPD1 repressed E-cadherin expression to promote cell invasion and migration for poor prognosis in oral squamous cell carcinoma" Sci. Rep. (2019) 10.1038/s41598-019-45489-1
[20]
Kashyap "Dihydrotanshinone-I modulates epithelial mesenchymal transition (EMT) thereby impairing migration and clonogenicity of triple negative breast cancer cells" Asian Pac. J. Cancer Prev. APJCP : Asian Pac. J. Cancer Prev. APJCP (2021) 10.31557/apjcp.2021.22.7.2177
[21]
Kim "Dihydrotanshinone-induced NOX5 activation inhibits breast cancer stem cell through the ROS/Stat3 signaling pathway" Oxid. Med. Cell. Longev. (2019) 10.1155/2019/9296439
[22]
Lin "Cancer and ER stress: mutual crosstalk between autophagy, oxidative stress and inflammatory response" Biomed.; Pharmacother. = Biomed.; Pharmacother. (2019)
[23]
Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis

Chunfeng Liu, Matjaz Rokavec, Zekai Huang et al.

Cell Death & Differentiation 2023 10.1038/s41418-023-01178-1
[24]
Lu "Lorlatinib for previously treated ALK-positive advanced NSCLC: primary efficacy and safety from a phase 2 study in people's Republic of China" J. Thorac. Oncol. : Off. Publ. Int. Assoc. Study of Lung Cancer (2022) 10.1016/j.jtho.2022.02.014
[25]
Makovec "Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapy" Radiol. Oncol. (2019) 10.2478/raon-2019-0018
[26]
Matsuzawa "Stress-responsive protein kinases in redox-regulated apoptosis signaling" Antioxidants Redox Signal. (2005) 10.1089/ars.2005.7.472
[27]
Meng "Toward developing chemical modulators of Hsp60 as potential therapeutics" Front. Mol. Biosci. (2018) 10.3389/fmolb.2018.00035
[28]
Min "Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-κB survival machinery in cancer cells" Redox Biol. (2022) 10.1016/j.redox.2022.102293
[29]
Paithankar "Heavy metal associated health hazards: an interplay of oxidative stress and signal transduction" Chemosphere (2021) 10.1016/j.chemosphere.2020.128350
[30]
Parma "Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting" J. Exp. Clin. Cancer Res. (2021) 10.1186/s13046-021-02049-8
[31]
Perillo "ROS in cancer therapy: the bright side of the moon" Exp. Mol. Med. (2020) 10.1038/s12276-020-0384-2
[32]
Pizzino "Cadmium-induced oxidative stress impairs glycemic control in adolescents" Oxid. Med. Cell. Longev. (2017) 10.1155/2017/6341671
[33]
Qiu "Cancer incidence, mortality, and burden in China: a time-trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020" Cancer Commun. (2021) 10.1002/cac2.12197
[34]
Shi "Identification of dihydrotanshinone I as an ERp57 inhibitor with anti-breast cancer properties via the UPR pathway" Biochem. Pharmacol. (2021) 10.1016/j.bcp.2021.114637
[35]
Srinivas "ROS and the DNA damage response in cancer" Redox Biol. (2019) 10.1016/j.redox.2018.101084
[36]
Sun "Dihydrotanshinone I inhibits ovarian tumor growth by activating oxidative stress through Keap1-mediated Nrf2 ubiquitination degradation" Free Radic. Biol. Med. (2022) 10.1016/j.freeradbiomed.2022.01.015
[37]
Sun "Nox4 promotes RANKL-induced autophagy and osteoclastogenesis via activating ROS/PERK/eIF-2α/ATF4 pathway" Front. Pharmacol. (2021) 10.3389/fphar.2021.751845
[38]
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

Hyuna Sung, Jacques Ferlay, Rebecca L. Siegel et al.

CA: A Cancer Journal for Clinicians 2021 10.3322/caac.21660
[39]
Tang "Down-regulation of HSP60 suppresses the proliferation of glioblastoma cells via the ROS/AMPK/mTOR pathway" Sci. Rep. (2016)
[40]
Trachootham "Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?" Nat. Rev. Drug Discov. (2009) 10.1038/nrd2803
[41]
Wang "The novel curcumin derivative 1g induces mitochondrial and ER-stress-dependent apoptosis in colon cancer cells by induction of ROS production" Front. Oncol. (2021)
[42]
Wang "Dihydrotanshinone induces p53-independent but ROS-dependent apoptosis in colon cancer cells" Life Sci. (2013) 10.1016/j.lfs.2013.07.007
[43]
Wang "New developments in the chemistry and biology of the bioactive constituents of Tanshen" Med. Res. Rev. (2007) 10.1002/med.20077
[44]
Wang "Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene" J. Cell Mol. Med. (2020) 10.1111/jcmm.15660
[45]
Wong "Identification of 5-fluorouracil response proteins in colorectal carcinoma cell line SW480 by two-dimensional electrophoresis and MALDI-TOF mass spectrometry" Oncol. Rep. (2008)
[46]
Wu "Heat shock proteins and cancer" Trends Pharmacol. Sci. (2017) 10.1016/j.tips.2016.11.009
[47]
Xu "Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1" Signal Transduct. Targeted Ther. (2023) 10.1038/s41392-022-01231-4
[48]
Xu "Heat shock protein-60 expression was significantly correlated with the prognosis of lung adenocarcinoma" J. Surg. Oncol. (2011) 10.1002/jso.21992
[49]
Yu "Dihydroartemisinin enhances the anti-tumor activity of oxaliplatin in colorectal cancer cells by altering PRDX2-reactive oxygen species-mediated multiple signaling pathways" Phytomedicine (2022) 10.1016/j.phymed.2022.153932
[50]
Zhao "Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer" J. Transl. Med. (2022) 10.1186/s12967-022-03741-9
Cited By
7
Metrics
7
Citations
50
References
Details
Published
May 01, 2025
Vol/Issue
994
Pages
177378
License
View
Funding
National Natural Science Foundation of China
Cite This Article
Haizhen Lin, Hehuan Sui, Ying Yu, et al. (2025). Dihydrotanshinone I potentiates the anti-tumor activity of cisplatin by activating ROS-mediated ER stress through targeting HSPD1 in lung cancer cells. European Journal of Pharmacology, 994, 177378. https://doi.org/10.1016/j.ejphar.2025.177378
Related

You May Also Like

Cisplatin in cancer therapy: Molecular mechanisms of action

Shaloam Dasari, Paul Bernard Tchounwou · 2014

4,595 citations

Macrophage M1/M2 polarization

Chen Yunna, Hu Mengru · 2020

2,080 citations

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

Ankita Mehta, Mayank Prabhakar · 2013

569 citations

Animal models of atherosclerosis

Besa Emini Veseli, Paola Perrotta · 2017

479 citations