journal article Open Access Sep 01, 2024

IL-6 induces Treg dysfunction in desiccating stress-induced dry eye disease

View at Publisher Save 10.1016/j.exer.2024.110006
Topics

No keywords indexed for this article. Browse by subject →

References
35
[1]
Amparo "Comparison of two questionnaires for dry eye symptom assessment: the ocular surface disease index and the symptom assessment in dry eye" Ophthalmology (2015) 10.1016/j.ophtha.2015.02.037
[2]
Arkatkar "B cell–derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity" J. Exp. Med. (2017) 10.1084/jem.20170580
[3]
Barabino "The controlled-environment chamber: a new mouse model of dry eye" Investigat. Opthalmol. Visual Sci. (2005) 10.1167/iovs.04-1326
[4]
Campbell "Control of regulatory T cell migration, function, and homeostasis" J. Immunol. (2015) 10.4049/jimmunol.1500801
[5]
Chauhan "Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression" J. Immunol. (2009) 10.4049/jimmunol.182.3.1247
[6]
Chauhan "Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation" J. Immunol. (2009) 10.4049/jimmunol.182.1.148
[7]
Chen "Chronic dry eye disease is principally mediated by effector memory Th17 cells" Mucosal Immunol. (2014) 10.1038/mi.2013.20
[8]
Dana "Patient-reported burden of dry eye disease in the United States: results of an online cross-sectional survey" Am. J. Ophthalmol. (2020) 10.1016/j.ajo.2020.03.044
[9]
Dienz "The effects of IL-6 on CD4 T cell responses" Clin. Immunol. (2009) 10.1016/j.clim.2008.08.018
[10]
Fan "Autoreactive memory Th17 cells are principally derived from T-bet+RORγt+ Th17/1 effectors" J. Autoimmun. (2022) 10.1016/j.jaut.2022.102816
[11]
Foulsham "Review: the function of regulatory T cells at the ocular surface" Ocul. Surf. (2017) 10.1016/j.jtos.2017.05.013
[12]
Hua "Pathological conversion of regulatory T cells is associated with loss of allotolerance" Sci. Rep. (2018) 10.1038/s41598-018-25384-x
[13]
Hua "Graft site microenvironment determines dendritic cell trafficking through the CCR7-CCL19/21 axis" Invest. Ophthalmol. Vis. Sci. (2016) 10.1167/iovs.15-17551
[14]
IL-6 as a keystone cytokine in health and disease

Christopher A Hunter, Simon A Jones

Nature Immunology 2015 10.1038/ni.3153
[15]
Inomata "Impaired function of peripherally induced regulatory T cells in hosts at high risk of graft rejection" Sci. Rep. (2016) 10.1038/srep39924
[16]
Jin "Role of CCR7 in facilitating direct allosensitization and regulatory T-cell function in high-risk corneal transplantation" Invest. Ophthalmol. Vis. Sci. (2010) 10.1167/iovs.09-3952
[17]
Kodati "Interleukin-6 neutralization prolongs corneal allograft survival" Curr. Trends Immunol. (2018)
[18]
Lemp "The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international Dry Eye WorkShop" Ocul. Surf. (2007)
[19]
Luo "Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface" Investigat. Opthalmol. Visual Sci. (2004) 10.1167/iovs.03-1145
[20]
Ma "Pigment epithelium-derived factor (PEDF) plays anti-inflammatory roles in the pathogenesis of dry eye disease" Ocul. Surf. (2021) 10.1016/j.jtos.2020.12.007
[21]
Dry Eye Disease and Tear Cytokine Levels—A Meta-Analysis

Matilde Roda, Ivan Corazza, Maria Letizia Bacchi Reggiani et al.

International Journal of Molecular Sciences 2020 10.3390/ijms21093111
[22]
Shao "Local delivery of regulatory T cells promotes corneal allograft survival" Transplantation (2019) 10.1097/tp.0000000000002442
[23]
Siemasko "In vitro expanded CD4 + CD25 + Foxp3 + regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation" Investigat. Opthalmol. Visual Sci. (2008) 10.1167/iovs.08-2075
[24]
Singh "Pigment epithelium–derived factor enhances the suppressive phenotype of regulatory T cells in a murine model of dry eye disease" Am. J. Pathol. (2021) 10.1016/j.ajpath.2021.01.003
[25]
Singh "Modulating the tachykinin: role of substance P and neurokinin receptor expression in ocular surface disorders" Ocul. Surf. (2022) 10.1016/j.jtos.2022.06.007
[26]
Stevenson "Dry eye disease: an immune-mediated ocular surface disorder" Arch. Ophthalmol. (2012) 10.1001/archophthalmol.2011.364
[27]
Tahvildari "Low-dose IL-2 therapy in transplantation, autoimmunity, and inflammatory diseases" J. Immunol. (2019) 10.4049/jimmunol.1900733
[28]
Taketani "Restoration of regulatory T-cell function in dry eye disease by antagonizing substance P/Neurokinin-1 receptor" Am. J. Pathol. (2020) 10.1016/j.ajpath.2020.05.011
[29]
Tsubota "Defining dry eye from a clinical perspective" Int. J. Mol. Sci. (2020) 10.3390/ijms21239271
[30]
Turner "Interleukin-6 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic emulsion" Cornea (2000) 10.1097/00003226-200007000-00018
[31]
Wang "Modifiable lifestyle risk factors for dry eye disease" Contact Lens Anterior Eye (2021) 10.1016/j.clae.2021.01.004
[32]
Wolffsohn "Demographic and lifestyle risk factors of dry eye disease subtypes: a cross-sectional study" Ocul. Surf. (2021) 10.1016/j.jtos.2021.05.001
[33]
Xiao "Dynamic ocular surface and lacrimal gland changes induced in experimental murine dry eye" PLoS One (2015)
[34]
Yoon "Interleukin-6 and tumor necrosis factor-α levels in tears of patients with dry eye syndrome" Cornea (2007) 10.1097/ico.0b013e31803dcda2
[35]
Yu "Neurokinin-1 receptor antagonism ameliorates dry eye disease by inhibiting antigen-presenting cell maturation and T helper 17 cell activation" Am. J. Pathol. (2020) 10.1016/j.ajpath.2019.09.020
Metrics
14
Citations
35
References
Details
Published
Sep 01, 2024
Vol/Issue
246
Pages
110006
License
View
Funding
National Institutes of Health
National Eye Institute Award: R01 EY020889
Cite This Article
Gustavo Ortiz, Tomas Blanco, Rohan Bir Singh, et al. (2024). IL-6 induces Treg dysfunction in desiccating stress-induced dry eye disease. Experimental Eye Research, 246, 110006. https://doi.org/10.1016/j.exer.2024.110006
Related

You May Also Like

Age-related nuclear cataract—oxidation is the key

Roger J.W. Truscott · 2005

668 citations

The sclera and myopia

Jody A. Summers Rada, Setareh Shelton · 2006

422 citations

Neural basis of sensation in intact and injured corneas

Carlos Belmonte, M. Carmen Acosta · 2004

414 citations