Teleost bone morphogenetic protein 2 (BMP2): Dynamic responses to infection and negative feedback regulation of inflammatory cytokines in gills of flounder (Paralichthys olivaceus)

Zefan Xu; Yingqin Liu; Xiuzhen Sheng; Xiaoqian Tang; Jing Xing; Heng Chi; Wenbin Zhan

doi:10.1016/j.fsi.2026.111329

journal article Jul 01, 2026

Teleost bone morphogenetic protein 2 (BMP2): Dynamic responses to infection and negative feedback regulation of inflammatory cytokines in gills of flounder (Paralichthys olivaceus)

Zefan Xu Yingqin Liu Xiuzhen Sheng

Xiaoqian Tang Jing Xing Heng Chi Wenbin Zhan

Fish & Shellfish Immunology Vol. 174 pp. 111329 · Elsevier BV

View at Publisher Save 10.1016/j.fsi.2026.111329

Topics

No keywords indexed for this article. Browse by subject →

References

75

[1]

The mucosal immune system of fish: The evolution of tolerating commensals while fighting pathogens

Daniela Gomez, J. Oriol Sunyer, Irene Salinas

Fish & Shellfish Immunology 2013 10.1016/j.fsi.2013.09.032

[2]

Salinas "The mucosal immune system of teleost fish" Biology (2015) 10.3390/biology4030525

[3]

Wang "Teleost Muc2 and Muc5ac: key guardians of mucosal immunity in flounder (Paralichthys Olivaceus)" Int. J. Biol. Macromol. (2024)

[4]

Gómez "Biology and mucosal immunity to myxozoans" Dev. Comp. Immunol. (2014) 10.1016/j.dci.2013.08.014

[5]

Liang "Structural characteristics and mucosal immune response of the interbranchial lymphoid tissue in the gills of flounder (Paralichthys Olivaceus)" Fish Shellfish Immunol. (2022) 10.1016/j.fsi.2022.03.022

[6]

Miyazono "BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk" Cytokine Growth Factor Rev. (2005) 10.1016/j.cytogfr.2005.01.009

[7]

Chen "Immunoregulation by members of the TGFβ superfamily" Nat. Rev. Immunol. (2016) 10.1038/nri.2016.112

[8]

Imamura "Smad6 inhibits signalling by the TGF-beta superfamily" Nature (1997) 10.1038/39355

[9]

Ishida "Smad6 is a Smad1/5-Induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter" J. Biol. Chem. (2000) 10.1074/jbc.275.9.6075

[10]

Zhang "Non-smad signaling pathways of the TGF-β family" Cold Spring Harbor Perspect. Biol. (2017) 10.1101/cshperspect.a022129

[11]

Kimura "BMP2-Induced apoptosis is mediated by activation of the TAK1-P38 kinase pathway that is negatively regulated by Smad6" J. Biol. Chem. (2000) 10.1074/jbc.m908622199

[12]

Sconocchia "Regulation of the immune system in health and disease by members of the bone morphogenetic protein family" Front. Immunol. (2021) 10.3389/fimmu.2021.802346

[13]

Sconocchia "Bone morphogenetic protein signaling regulates skin inflammation via modulating dendritic cell function" J. Allergy Clin. Immunol. (2021) 10.1016/j.jaci.2020.09.038

[14]

Ganjoo "Bone morphogenetic proteins, activins, and growth and differentiation factors in tumor immunology and immunotherapy resistance" Front. Immunol. (2022) 10.3389/fimmu.2022.1033642

[15]

Yue "BMP signaling alleviates allergic airway inflammation by controlling group 2 innate lymphoid cells homeostasis" Eur. J. Immunol. (2025) 10.1002/eji.70038

[16]

Mahadik "Deregulated AUF1 assists BMP-EZH2–Mediated delayed wound healing during Candida albicans infection" J. Immunol. (2018) 10.4049/jimmunol.1800688

[17]

Takabayashi "Anti-inflammatory activity of bone morphogenetic protein signaling pathways in stomachs of mice" Gastroenterology (2014) 10.1053/j.gastro.2014.04.015

[18]

Tellez Freitas "The nuclear variant of bone morphogenetic protein 2 (nBMP2) is expressed in macrophages and alters calcium response" Sci. Rep. (2019) 10.1038/s41598-018-37329-5

[19]

Liao "1,3-and 1,4-Linked polysaccharides uptake in intestinal cells relies on clathrin/dynamin 1/Rab5-Dependent endocytosis" Nat. Commun. (2026) 10.1038/s41467-026-68542-w

[20]

Hine "Intestinal macrophages in resolving inflammation" J. Immunol. (2019) 10.4049/jimmunol.1900345

[21]

Hochgerner "Loss of ALK3 ameliorates acute but aggravates chronic lung inflammation in vivo" Immunology (2025) 10.1111/imm.13957

[22]

Wang "Stromal BMP signaling regulates mucin production in the large intestine via Interleukin-1/17" Sci. Adv. (2023) 10.1126/sciadv.adi1827

[23]

Nishio "Functional expression of BMP7 receptors in oral epithelial cells. Interleukin-17F production in response to BMP7" J. Recept. Signal Transduction (2017) 10.1080/10799893.2017.1360352

[24]

Chen "Intestinal mucosal barrier is injured by BMP2/4 via activation of NF-κB signals after ischemic reperfusion" Mediat. Inflamm. (2014)

[25]

Wirtz "Chemically induced mouse models of acute and chronic intestinal inflammation" Nat. Protoc. (2017) 10.1038/nprot.2017.044

[26]

Zhong "Bmp8a is an essential positive regulator of antiviral immunity in zebrafish" Commun. Biol. (2021) 10.1038/s42003-021-01811-0

[27]

Chen "Bmp4 in zebrafish enhances antiviral innate immunity through P38 MAPK (Mitogen-Activated protein kinases) pathway" Int. J. Mol. Sci. (2023) 10.3390/ijms241914444

[28]

Kim "Expression of bone morphogenetic protein receptors Type-IA, -IB, and -II correlates with tumor grade in human prostate cancer tissues" Cancer Res. (2000)

[29]

Diverse Biological Effect and Smad Signaling of Bone Morphogenetic Protein 7 in Prostate Tumor Cells

Shangxin Yang, Chen Zhong, Baruch Frenkel et al.

Cancer Research 2005 10.1158/0008-5472.can-05-0289

[30]

Cloning of human bone morphogenetic protein type IB receptor (BMPR-IB) and its expression in prostate cancer in comparison with other BMPRs

Hisamitsu Ide, Masaru Katoh, Hiroki Sasaki et al.

Oncogene 1997 10.1038/sj.onc.1200964

[31]

Hardwick "Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the Colon" Gastroenterology (2004) 10.1053/j.gastro.2003.10.067

[32]

He "Co-Treatment with rhBMP-2 and rapamycin modulates osteogenesis-adipogenesis balance to enhance aged bone regeneration" Advanced Science (Weinheim, Baden-Wurttemberg, Germany) (2026)

[33]

Rosendahl "Activation of bone morphogenetic protein/smad signaling in bronchial epithelial cells during airway inflammation" Am. J. Respir. Cell Mol. Biol. (2002) 10.1165/ajrcmb.27.2.4779

[34]

Kapalczynska "BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. Pylori-driven inflammation" Nat. Commun. (2022) 10.1038/s41467-022-29176-w

[35]

Kim "Bone morphogenetic Protein-2 as a novel biomarker for refractory chronic rhinosinusitis with nasal polyps" J. Allergy Clin. Immunol. (2021) 10.1016/j.jaci.2021.02.027

[36]

Matveeva "BMP-2 and IL-1β as markers of nasal mucosa inflammation in rhinosinusitis with nasal polyps" Bull. Exp. Biol. Med. (2023) 10.1007/s10517-023-05728-y

[37]

Marques "Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives" Cell. Mol. Life Sci. (2015) 10.1007/s00018-015-2024-x

[38]

Marques "Spatiotemporal expression and retinoic acid regulation of bone morphogenetic proteins 2, 4 and 16 in Senegalese sole" J. Appl. Ichthyol. (2014) 10.1111/jai.12539

[39]

Zhang "Characterization and spatiotemporal expression analysis of nine bone morphogenetic protein family genes during intermuscular bone development in blunt snout bream" Gene (2018) 10.1016/j.gene.2017.11.027

[40]

Luckenbach "Follicle-stimulating hormone regulation of ovarian transcripts for steroidogenesis-related proteins and cell survival, growth and differentiation factors in Vitro during early secondary oocyte growth in coho salmon" Gen. Comp. Endocrinol. (2011) 10.1016/j.ygcen.2010.12.016

[41]

Xu "The distribution and function of teleost IgT" Fish Shellfish Immunol. (2024) 10.1016/j.fsi.2023.109281

[42]

Wu "Transcriptome analysis of flounder (Paralichthys olivaceus) gill in response to lymphocystis disease virus (LCDV) infection: novel insights into fish defense mechanisms" Int. J. Mol. Sci. (2018) 10.3390/ijms19010160

[43]

Sheng "Upregulation of polymeric Immunoglobulin receptor expression in flounder (Paralichthys olivaceus) gill cells by cytokine tumor necrosis Factor-α via activating PI3K and NF-κB signaling pathways" Mol. Immunol. (2021) 10.1016/j.molimm.2021.04.011

[44]

Zhong "Development and characterization of monoclonal antibodies to the 32 kDa viral attachment protein of lymphocystis disease virus and their neutralizing ability in Vitro" Int. J. Mol. Sci. (2018) 10.3390/ijms19092536

[45]

Du "Immune response of flounder (Paralichthys olivaceus) was associated with the concentration of inactivated Edwardsiella tarda and immersion time" Vet. Immunol. Immunopathol. (2015) 10.1016/j.vetimm.2015.07.002

[46]

Li "Identification and expression analysis of nascent polypeptide-associated complex alpha gene in response to immune challenges in Japanese flounder Paralichthys olivaceus" Fish Shellfish Immunol. (2015) 10.1016/j.fsi.2015.06.033

[47]

Chen "Characterization of the Japanese flounder NLRP3 inflammasome in restricting Edwardsiella piscicida colonization In Vivo" Fish Shellfish Immunol. (2020) 10.1016/j.fsi.2020.04.063

[48]

Wang "Macrophages inhibit ciliary protein levels by secreting BMP-2 leading to airway epithelial remodeling under cigarette smoke exposure" Front. Mol. Biosci. (2021)

[49]

Berková "Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members" EMBO Rep. (2023) 10.15252/embr.202256454

[50]

Yang "Sildenefil increases connexin 40 in smooth muscle cells through activation of BMP pathways in pulmonary arterial hypertension" Int. J. Clin. Exp. Pathol. (2014)

Showing 50 of 75 references

Metrics

0

Citations

75

References

Details

Published: Jul 01, 2026
Vol/Issue: 174
Pages: 111329
License: View

Authors

Funding

National Natural Science Foundation of China Award: 32273163

National Key Research and Development Program of China Award: 2024YFD2400102

Cite This Article

Zefan Xu, Yingqin Liu, Xiuzhen Sheng, et al. (2026). Teleost bone morphogenetic protein 2 (BMP2): Dynamic responses to infection and negative feedback regulation of inflammatory cytokines in gills of flounder (Paralichthys olivaceus). Fish & Shellfish Immunology, 174, 111329. https://doi.org/10.1016/j.fsi.2026.111329

Teleost bone morphogenetic protein 2 (BMP2): Dynamic responses to infection and negative feedback regulation of inflammatory cytokines in gills of flounder (Paralichthys olivaceus)

You May Also Like