journal article Open Access Aug 01, 2006

Differential Activity of IL-12 and IL-23 in Mucosal and Systemic Innate Immune Pathology

Immunity Vol. 25 No. 2 pp. 309-318 · Elsevier BV
View at Publisher Save 10.1016/j.immuni.2006.05.017
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References
41
[1]
Becker "Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells" J. Clin. Invest. (2003) 10.1172/jci200317464
[2]
Bouma "The immunological and genetic basis of inflammatory bowel disease" Nat. Rev. Immunol. (2003) 10.1038/nri1132
[3]
Cong "Colitis induced by enteric bacterial antigen-specific CD4+ T cells requires CD40-CD40 ligand interactions for a sustained increase in mucosal IL-12" J. Immunol. (2000) 10.4049/jimmunol.165.4.2173
[4]
Cua "Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain" Nature (2003) 10.1038/nature01355
[5]
De Jong "Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration" Gastroenterology (2000) 10.1053/gast.2000.16485
[6]
Diehl "The role of CD40 in peripheral T cell tolerance and immunity" J. Mol. Med. (2000) 10.1007/s001090000126
[7]
NOD2 and Crohn’s Disease: Loss or Gain of Function?

Lars Eckmann, Michael Karin

Immunity 2005 10.1016/j.immuni.2005.06.004
[8]
Ferlin "CD40 signaling induces interleukin-4-independent IgE switching in vivo" Eur. J. Immunol. (1996) 10.1002/eji.1830261216
[9]
Fuss "Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice" Gastroenterology (1999) 10.1016/s0016-5085(99)70392-6
[10]
Harrington "Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages" Nat. Immunol. (2005) 10.1038/ni1254
[11]
Hunter "New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions" Nat. Rev. Immunol. (2005) 10.1038/nri1648
[12]
Isler "Interleukin-12 production by human alveolar macrophages is controlled by the autocrine production of interleukin-10" Am. J. Respir. Cell Mol. Biol. (1999) 10.1165/ajrcmb.20.2.3313
[13]
Kelsall "Interleukin-12 production by dendritic cells. The role of CD40-CD40L interactions in Th1 T-cell responses" Ann. N Y Acad. Sci. (1996) 10.1111/j.1749-6632.1996.tb52660.x
[14]
Krajina "Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis" Eur. J. Immunol. (2003) 10.1002/eji.200323518
[15]
Langrish "IL-12 and IL-23: master regulators of innate and adaptive immunity" Immunol. Rev. (2004) 10.1111/j.0105-2896.2004.00214.x
[16]
Langrish "IL-23 drives a pathogenic T cell population that induces autoimmune inflammation" J. Exp. Med. (2005) 10.1084/jem.20041257
[17]
Liu "Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production" J. Immunol. (1999) 10.4049/jimmunol.163.7.4049
[18]
Liu "Prevention of experimental colitis in SCID mice reconstituted with CD45RBhigh CD4+ T cells by blocking the CD40-CD154 interactions" J. Immunol. (2000) 10.4049/jimmunol.164.11.6005
[19]
Ma "TNF-alpha and IL-12: a balancing act in macrophage functioning" Microbes Infect. (2001) 10.1016/s1286-4579(00)01359-9
[20]
Malmstrom "CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice" J. Immunol. (2001) 10.4049/jimmunol.166.11.6972
[21]
Mannon "Anti-interleukin-12 antibody for active Crohn's disease" N. Engl. J. Med. (2004) 10.1056/nejmoa033402
[22]
Mason "Cutting edge: identification of c-Rel-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuli" J. Immunol. (2002) 10.4049/jimmunol.168.6.2590
[23]
McKenzie "Understanding the IL-23-IL-17 immune pathway" Trends Immunol. (2005) 10.1016/j.it.2005.10.003
[24]
Morelli "Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation" Blood (2001) 10.1182/blood.v98.5.1512
[25]
Murphy "Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation" J. Exp. Med. (2003) 10.1084/jem.20030896
[26]
Neurath "Antibodies to interleukin 12 abrogate established experimental colitis in mice" J. Exp. Med. (1995) 10.1084/jem.182.5.1281
[27]
Neurath "Effect of IL-12 and antibodies to IL-12 on established granulomatous colitis in mice" Ann. N Y Acad. Sci. (1996) 10.1111/j.1749-6632.1996.tb52695.x
[28]
Oppmann "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12" Immunity (2000) 10.1016/s1074-7613(00)00070-4
[29]
Parham "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R" J. Immunol. (2002) 10.4049/jimmunol.168.11.5699
[30]
Park "A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17" Nat. Immunol. (2005) 10.1038/ni1261
[31]
Polese "The role of CD40 in ulcerative colitis: histochemical analysis and clinical correlation" Eur. J. Gastroenterol. Hepatol. (2002) 10.1097/00042737-200203000-00006
[32]
Powrie "Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells" Immunity (1994) 10.1016/1074-7613(94)90045-0
[33]
Rolink "The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching" Immunity (1996) 10.1016/s1074-7613(00)80258-7
[34]
Sandborn "Biologics in inflammatory bowel disease: how much progress have we made?" Gut (2004) 10.1136/gut.2003.025452
[35]
Schmidt "Interleukin-12 antagonists as new therapeutic agents in inflammatory bowel disease" Pathobiology (2002) 10.1159/000068151
[36]
Shanahan "Crohn's disease" Lancet (2002) 10.1016/s0140-6736(02)07284-7
[37]
Simpson "T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells" J. Exp. Med. (1998) 10.1084/jem.187.8.1225
[38]
Strober "The immunology of mucosal models of inflammation" Annu. Rev. Immunol. (2002) 10.1146/annurev.immunol.20.100301.064816
[39]
Stuber "Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion" J. Exp. Med. (1996) 10.1084/jem.183.2.693
[40]
Trinchieri "The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses" Immunity (2003) 10.1016/s1074-7613(03)00296-6
[41]
van Kooten "CD40-CD40 ligand" J. Leukoc. Biol. (2000) 10.1002/jlb.67.1.2
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Details
Published
Aug 01, 2006
Vol/Issue
25(2)
Pages
309-318
License
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Funding
Wellcome Trust
Deutsche Forschungsgemeinschaft Award: H.H.U. 128-2
European Commission Award: EU-IMDEMI MRTN-CT2004-05632
Akademie ved Ceské Republiky Award: A5020205
Cite This Article
Holm H. Uhlig, Brent S. McKenzie, Sophie Hue, et al. (2006). Differential Activity of IL-12 and IL-23 in Mucosal and Systemic Innate Immune Pathology. Immunity, 25(2), 309-318. https://doi.org/10.1016/j.immuni.2006.05.017
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