The IL-17 Family of Cytokines in Health and Disease

Mandy J. McGeachy; Daniel J. Cua; Sarah L. Gaffen

doi:10.1016/j.immuni.2019.03.021

journal article Open Access Apr 01, 2019

The IL-17 Family of Cytokines in Health and Disease

Mandy J. McGeachy

Daniel J. Cua Sarah L. Gaffen

Immunity Vol. 50 No. 4 pp. 892-906 · Elsevier BV

View at Publisher Save 10.1016/j.immuni.2019.03.021

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References

195

[1]

Ahmed "IL-17 inhibits adipogenesis in part via C/EBPα, PPARγ and Krüppel-like factors" Cytokine (2013) 10.1016/j.cyto.2012.12.007

[2]

Akimzhanov "Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation" J. Biol. Chem. (2007) 10.1074/jbc.c600322200

[3]

Akira "Regnase-1, a ribonuclease involved in the regulation of immune responses" Cold Spring Harb. Symp. Quant. Biol. (2013) 10.1101/sqb.2013.78.019877

[4]

Albanesi "IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-gamma and TNF-alpha" J. Immunol. (1999) 10.4049/jimmunol.162.1.494

[5]

Amatya "IL-17 integrates multiple self-reinforcing, feed-forward mechanisms through the RNA-binding protein Arid5a" Sci Signal (2018) 10.1126/scisignal.aat4617

[6]

Amatya "IL-17 Signaling: The Yin and the Yang" Trends Immunol. (2017) 10.1016/j.it.2017.01.006

[7]

Amicarella "Dual role of tumour-infiltrating T helper 17 cells in human colorectal cancer" Gut (2017) 10.1136/gutjnl-2015-310016

[8]

Amir "REV-ERBα Regulates TH17 Cell Development and Autoimmunity" Cell Rep (2018) 10.1016/j.celrep.2018.11.101

[9]

Antonysamy "Evidence for a role of IL-17 in organ allograft rejection: IL-17 promotes the functional differentiation of dendritic cell progenitors" J. Immunol. (1999) 10.4049/jimmunol.162.1.577

[10]

Atarashi "Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells" Cell (2015) 10.1016/j.cell.2015.08.058

[11]

Baeten "Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis" N. Engl. J. Med. (2015) 10.1056/nejmoa1505066

[12]

Baeten "Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study" Ann. Rheum. Dis. (2018) 10.1136/annrheumdis-2018-213328

[13]

Bagheri "The biological functions of IL-17 in different clinical expressions of Helicobacter pylori-infection" Microb. Pathog. (2015) 10.1016/j.micpath.2015.03.010

[14]

Bär "A novel Th cell epitope of Candida albicans mediates protection from fungal infection" J. Immunol. (2012) 10.4049/jimmunol.1200594

[15]

Beale "Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation" Sci. Transl. Med. (2014) 10.1126/scitranslmed.3009124

[16]

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

Corinne Benakis, David Brea, Silvia Caballero et al.

Nature Medicine 2016 10.1038/nm.4068

[17]

Beurel "Th17 cells in depression" Brain Behav. Immun. (2018) 10.1016/j.bbi.2017.08.001

[18]

Beurel "Inflammatory T helper 17 cells promote depression-like behavior in mice" Biol. Psychiatry (2013) 10.1016/j.biopsych.2012.09.021

[19]

Bie "IL-17B: A new area of study in the IL-17 family" Mol. Immunol. (2017) 10.1016/j.molimm.2017.07.004

[20]

Bie "IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells" Oncotarget (2017) 10.18632/oncotarget.14835

[21]

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

Chamutal Bornstein, Shir Nevo, Amir Giladi et al.

Nature 2018 10.1038/s41586-018-0346-1

[22]

Buckley "IL17 factors are early regulators in the gut epithelium during inflammatory response to Vibrio in the sea urchin larva" eLife (2017) 10.7554/elife.23481

[23]

Bulek "The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation" Nat. Immunol. (2011) 10.1038/ni.2080

[24]

Chang "A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses" Cell Res. (2007) 10.1038/cr.2007.35

[25]

Chang "Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor" J. Biol. Chem. (2006) 10.1074/jbc.c600256200

[26]

Chen "mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production" J. Immunol. (2016) 10.4049/jimmunol.1501541

[27]

Chen "IL-17R-EGFR axis links wound healing to tumorigenesis in Lrig1+ stem cells" J. Exp. Med. (2019) 10.1084/jem.20171849

[28]

Chiricozzi "IL-17 targeted therapies for psoriasis" Expert Opin. Investig. Drugs (2013) 10.1517/13543784.2013.806483

[29]

Integrative Responses to IL-17 and TNF-α in Human Keratinocytes Account for Key Inflammatory Pathogenic Circuits in Psoriasis

Andrea Chiricozzi, Emma Guttman-Yassky, Mayte Suárez-Fariñas et al.

Journal of Investigative Dermatology 2011 10.1038/jid.2010.340

[30]

Choi "The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring" Science (2016) 10.1126/science.aad0314

[31]

Chung "An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy" Nat. Med. (2013) 10.1038/nm.3291

[32]

Conti "IL-17-Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans" J. Immunol. (2015) 10.4049/jimmunol.1500909

[33]

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

Heather R. Conti, Namrata Nayyar, Eileen Stocum et al.

Journal of Experimental Medicine 2009 10.1084/jem.20081463

[34]

IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis

Heather R. Conti, Vincent M. Bruno, Erin E. Childs et al.

Cell Host & Microbe 2016 10.1016/j.chom.2016.10.001

[35]

Cruz "Interleukin-17 signaling triggers degradation of the constitutive NF-κB inhibitor ABIN-1" Immunohorizons (2017) 10.4049/immunohorizons.1700035

[36]

Cua "Innate IL-17-producing cells: the sentinels of the immune system" Nat. Rev. Immunol. (2010) 10.1038/nri2800

[37]

Datta "IL-17 regulates CXCL1 mRNA stability via an AUUUA/tristetraprolin-independent sequence" J. Immunol. (2010) 10.4049/jimmunol.0902423

[38]

Dejea "Microbiota organization is a distinct feature of proximal colorectal cancers" Proc. Natl. Acad. Sci. USA (2014) 10.1073/pnas.1406199111

[39]

Dejea "Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria" Science (2018) 10.1126/science.aah3648

[40]

Diaz "PD-1 Blockade in Tumors with Mismatch-Repair Deficiency" N. Engl. J. Med. (2015) 10.1056/nejmc1510353

[41]

Drummond "Organ-specific mechanisms linking innate and adaptive antifungal immunity" Semin. Cell Dev. Biol. (2018)

[42]

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

Richard H. Duerr, Kent D. Taylor, Steven R. Brant et al.

Science 2006 10.1126/science.1135245

[43]

Dutzan "On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier" Immunity (2017) 10.1016/j.immuni.2016.12.010

[44]

Esfahani "Reversal of Autoimmune Toxicity and Loss of Tumor Response by Interleukin-17 Blockade" N. Engl. J. Med. (2017) 10.1056/nejmc1703047

[45]

Eskan "The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss" Nat. Immunol. (2012) 10.1038/ni.2260

[46]

Faour "T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade: role of distal sequences in the 3′-untranslated region of COX-2 mRNA" J. Biol. Chem. (2003) 10.1074/jbc.m212790200

[47]

Faraco "Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response" Nat. Neurosci. (2018) 10.1038/s41593-017-0059-z

[48]

Farez "Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses" Cell (2015) 10.1016/j.cell.2015.08.025

[49]

Fleischmann "Safety, Tolerability, and Pharmacodynamics of ABT-122, a Tumor Necrosis Factor- and Interleukin-17-Targeted Dual Variable Domain Immunoglobulin, in Patients With Rheumatoid Arthritis" Arthritis Rheumatol. (2017) 10.1002/art.40319

[50]

Fort "IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo" Immunity (2001) 10.1016/s1074-7613(01)00243-6

Showing 50 of 195 references

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References

Details

Published: Apr 01, 2019
Vol/Issue: 50(4)
Pages: 892-906
License: View

Authors

M

Mandy J. McGeachy

Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

D

Daniel J. Cua

Janssen Research and Development, Spring House, PA, USA.

S

Sarah L. Gaffen

Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh Pittsburgh Pennsylvania

Funding

NIH Award: AI110822

Cite This Article

Mandy J. McGeachy, Daniel J. Cua, Sarah L. Gaffen (2019). The IL-17 Family of Cytokines in Health and Disease. Immunity, 50(4), 892-906. https://doi.org/10.1016/j.immuni.2019.03.021

The IL-17 Family of Cytokines in Health and Disease

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