Translatomic analysis of regenerating and degenerating spinal motor neurons in injury and ALS

Jennifer L. Shadrach; Wesley M. Stansberry; Allison M. Milen; Rachel E. Ives; Elizabeth A. Fogarty; Anthony Antonellis; Brian A. Pierchala

doi:10.1016/j.isci.2021.102700

journal article Open Access Jul 01, 2021

Translatomic analysis of regenerating and degenerating spinal motor neurons in injury and ALS

Jennifer L. Shadrach Wesley M. Stansberry Allison M. Milen Rachel E. Ives Elizabeth A. Fogarty Anthony Antonellis Brian A. Pierchala

iScience Vol. 24 No. 7 pp. 102700 · Elsevier BV

View at Publisher Save 10.1016/j.isci.2021.102700

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References

93

[1]

Arnold "ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43" Proc. Natl. Acad. Sci. U S A (2013) 10.1073/pnas.1222809110

[2]

CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data

Gabriela Bindea, Jérôme Galon, Bernhard Mlecnik

Bioinformatics 2013 10.1093/bioinformatics/btt019

[3]

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

Gabriela Bindea, Bernhard Mlecnik, Hubert Hackl et al.

Bioinformatics 2009 10.1093/bioinformatics/btp101

[4]

Blokhuis "Protein aggregation in amyotrophic lateral sclerosis" Acta Neuropathol. (2013) 10.1007/s00401-013-1125-6

[5]

Boillee "Onset and progression in inherited ALS determined by motor neurons and microglia" Science (2006) 10.1126/science.1123511

[6]

BonDurant "Fibroblast growth factor 21: a versatile regulator of metabolic homeostasis" Annu. Rev. Nutr. (2018) 10.1146/annurev-nutr-071816-064800

[7]

Bookout "FGF21 regulates metabolism and circadian behavior by acting on the nervous system" Nat. Med. (2013) 10.1038/nm.3249

[8]

(2017)

[9]

Bowen "Localization and regulation of MuSK at the neuromuscular junction" Dev. Biol. (1998) 10.1006/dbio.1998.8936

[10]

Brkic "Friends or Foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases" Med. Inflam. (2015) 10.1155/2015/620581

[11]

Single-Cell RNA-Seq Technologies and Related Computational Data Analysis

Geng Chen, Baitang Ning, Tieliu Shi

Frontiers in Genetics 2019 10.3389/fgene.2019.00317

[12]

Chen "Fibroblast growth factor 21 ameliorates neurodegeneration in rat and cellular models of Alzheimer’s disease" Redox Biol. (2019) 10.1016/j.redox.2019.101133

[13]

Chiu "A neurodegeneration-specific gene expression signature and immune profile of acutely isolated microglia from an ALS mouse model" Cell Rep (2013) 10.1016/j.celrep.2013.06.018

[14]

Chong "GAP-43 mRNA in rat spinal cord and dorsal root ganglia neurons: developmental changes and re-expression following peripheral nerve injury" Eur. J. Neurosci. (1992) 10.1111/j.1460-9568.1992.tb00115.x

[15]

Curtis "GAP-43 is expressed by nonmyelin-forming Schwann cells of the peripheral nervous system" J. Cell Biol. (1992) 10.1083/jcb.116.6.1455

[16]

De Gendt "Genome-wide identification of AR-regulated genes translated in Sertoli cells in vivo using the RiboTag approach" Mol. Endocrinol. (2014) 10.1210/me.2013-1391

[17]

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin, Carrie A. Davis, Felix Schlesinger et al.

Bioinformatics 2013 10.1093/bioinformatics/bts635

[18]

El Khoury "Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease" Nat. Med. (2007) 10.1038/nm1555

[19]

Ferraiuolo "Molecular pathways of motor neuron injury in amyothrophic lateral sclerosis" Nat. Rev. Neurol. (2011) 10.1038/nrneurol.2011.152

[20]

Fischer "Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man" Exp. Neurol. (2004) 10.1016/j.expneurol.2003.10.004

[21]

Floyd "Characterization of calbindin D28k expressing interneurons in the ventral horn of the mouse spinal cord" Dev. Dyn. (2018) 10.1002/dvdy.24601

[22]

Friese "Gamma and alpha motor neurons distinguished by expression of transcription factor Err3" Proc. Natl. Acad. Sci. U S A (2009) 10.1073/pnas.0906809106

[23]

Gitcho "TDP-43 A315T mutation in familial motor neuron disease" Ann. Neurol. (2008) 10.1002/ana.21344

[24]

Grinsell "Peripheral nerve reconstruction after injury: a review of clinical and experimental therapies" Biomed. Res. Int. (2014) 10.1155/2014/698256

[25]

Gschwandtner "More than just attractive: how CCL2 influences myeloid cell behavior beyond chemotaxis" Front. Immunol. (2019) 10.3389/fimmu.2019.02759

[26]

Gu "Complex heatmaps reveal patterns and correlations in multidimensional genomic data" Bioinformatics (2016) 10.1093/bioinformatics/btw313

[27]

Gupta "Temporal changes in PO and MBP gene expression after crush-injury of the adult peripheral nerve" Brain Res. (1988)

[28]

Gurney "Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation" Science (1994) 10.1126/science.8209258

[29]

He "Intrinsic control of axon regeneration" Neuron (2016) 10.1016/j.neuron.2016.04.022

[30]

Hulliger "The mammalian muscle spindle and its central control" Rev. Physiol. Biochem. Pharmacol. (1984)

[31]

Ilieva "Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond" J. Cell Biol. (2009) 10.1083/jcb.200908164

[32]

Inagaki "Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21" Cell Metab. (2007) 10.1016/j.cmet.2007.05.003

[33]

Itoh "Cell-specific and region-specific transcriptomics in the multiple sclerosis model: focus on astrocytes" Proc. Natl. Acad. Sci. U S A (2018) 10.1073/pnas.1716032115

[34]

Kanning "Motor neuron diversity in development and disease" Annu. Rev. Neurosci. (2010) 10.1146/annurev.neuro.051508.135722

[35]

Kennedy "Comparison of standard laminectomy with an optimized ejection method for the removal of spinal cords from rats and mice" J. Histotechnol (2013) 10.1179/014788813x13756994210382

[36]

Kwiatkowski "Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis" Science (2009) 10.1126/science.1166066

[37]

Lalancette-Hebert "Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS" Proc. Natl. Acad. Sci. U S A (2016) 10.1073/pnas.1605210113

[38]

Lappe-Siefke "Disruption of Cnp1 uncouples ologodendroglial functions in axonal support and myelination" Nat. Genet. (2003) 10.1038/ng1095

[39]

Leng "Valproic acid and other HDAC inhibitors upregulate FGF21 gene expression and promote process elongation in glia by inhibiting HDAC2 and 3" Int. J. Neuropsychopharmacol. (2016) 10.1093/ijnp/pyw035

[40]

Fast and accurate short read alignment with Burrows–Wheeler transform

Heng Li, Richard Durbin

Bioinformatics 2009 10.1093/bioinformatics/btp324

[41]

Lindborg "Molecular and cellular identification of the immune response in peripheral ganglia following nerve injury" J. Neuroinflammat. (2018) 10.1186/s12974-018-1222-5

[42]

Logsiger "Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons" Proc. Natl. Acad. Sci. US A (2007) 10.1073/pnas.0702230104

[43]

What makes a RAG regeneration associated?

Thong C. Ma, Dianna E. Willis

Frontiers in Molecular Neuroscience 2015 10.3389/fnmol.2015.00043

[44]

Makela "Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1alpha in human dopaminergic neurons via Sirtuin-1" SpringerPlus (2014) 10.1186/2193-1801-3-2

[45]

Martinez-Garza "Fibroblast growth factor 21 and the adaptive response to nutritional challenges" Int. J. Mol. Sci. (2019) 10.3390/ijms20194692

[46]

Merkulyeva "Distribution of 28 kDa calbindin-immunopositive neurons in the cat spinal cord" Front. Neuroanat. (2016) 10.3389/fnana.2015.00166

[47]

Nardo "Transcriptomic indicies of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis" Brain (2013) 10.1093/brain/awt250

[48]

Neumann "Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis" Science (2006) 10.1126/science.1134108

[49]

Niemi "A critical role for macrophages near axotomized neuronal cell bodies in stimulating nerve regeneration" J. Neurosci. (2013) 10.1523/jneurosci.3319-12.2013

[50]

Oost "Fibroblast growth factor 21 controls mitophagy and muscle mass" J. Cach Sarco Mus. (2019)

Showing 50 of 93 references

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References

Details

Published: Jul 01, 2021
Vol/Issue: 24(7)
Pages: 102700
License: View

Authors

Funding

NIH

University of Michigan

Cite This Article

Jennifer L. Shadrach, Wesley M. Stansberry, Allison M. Milen, et al. (2021). Translatomic analysis of regenerating and degenerating spinal motor neurons in injury and ALS. iScience, 24(7), 102700. https://doi.org/10.1016/j.isci.2021.102700

Translatomic analysis of regenerating and degenerating spinal motor neurons in injury and ALS

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