Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease

Alldred "Terminal continuation (TC) RNA amplification enables expression profiling using minute RNA input obtained from mouse brain" Int. J. Mol. Sci. (2008) 10.3390/ijms9112091

[3]

Alldred "Terminal continuation (TC) RNA amplification without second strand synthesis" J. Neurosci. Methods (2009) 10.1016/j.jneumeth.2008.10.027

[4]

Arimura "Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27" Dev. Cell (2009) 10.1016/j.devcel.2009.03.005

[5]

Arvanitakis "Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology" Neurology (2008) 10.1212/01.wnl.0000313813.48505.86

[6]

Bennett "Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function" Arch. Neurol. (2004) 10.1001/archneur.61.3.378

[7]

Bennett "Natural history of mild cognitive impairment in older persons" Neurology (2002) 10.1212/wnl.59.2.198

[8]

Bishop "Dynamics of endosomal sorting" Int. Rev. Cytol. (2003) 10.1016/s0074-7696(03)32001-7

[9]

Blalock "Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses" Proc. Natl. Acad. Sci. U. S. A. (2004) 10.1073/pnas.0308512100

[10]

Boissiere "Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease" Exp. Neurol. (1997) 10.1006/exnr.1997.6443

[11]

Bonanomi "Protein sorting in the synaptic vesicle life cycle" Prog. Neurobiol. (2006) 10.1016/j.pneurobio.2006.09.002

[12]

Neuropathological stageing of Alzheimer-related changes

H. Braak, E. Braak

Acta Neuropathologica 1991 10.1007/bf00308809

[13]

Endocytic Delivery to Lysosomes Mediated by Concurrent Fusion and Kissing Events in Living Cells

Nicholas A. Bright, Matthew J. Gratian, J.Paul Luzio

Current Biology 2005 10.1016/j.cub.2005.01.049

[14]

Bronfman "Endosomal transport of neurotrophins: roles in signaling and neurodegenerative diseases" Dev. Neurobiol. (2007) 10.1002/dneu.20513

[15]

Bruno "Increased matrix metalloproteinase 9 activity in mild cognitive impairment" J. Neuropathol. Exp. Neurol. (2009) 10.1097/nen.0b013e3181c22569

[16]

Cataldo "Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders" Ann. Neurol. (2001) 10.1002/ana.1254

[17]

Cataldo "Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased β-amyloidogenesis" J. Neurosci. (1997) 10.1523/jneurosci.17-16-06142.1997

[18]

Cataldo "Properties of the endosomal–lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease" J. Neurosci. (1996) 10.1523/jneurosci.16-01-00186.1996

[19]

Cataldo "Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects" Am. J. Pathol. (2008) 10.2353/ajpath.2008.071053

[20]

Cataldo "App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of Down syndrome" J. Neurosci. (2003) 10.1523/jneurosci.23-17-06788.2003

[21]

Cataldo "Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations" Am. J. Pathol. (2000) 10.1016/s0002-9440(10)64538-5

[22]

Che "Amplification of transcripts using terminal continuation" Lab. Invest. (2004) 10.1038/sj.labinvest.3700005

[23]

Chouliaras "Epigenetic regulation in the pathophysiology of Alzheimer's disease" Prog. Neurobiol. (2010) 10.1016/j.pneurobio.2010.01.002

[24]

Chu "Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease" J. Comp. Neurol. (2001) 10.1002/cne.1284

[25]

Colangelo "Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling" J. Neurosci. Res. (2002) 10.1002/jnr.10351

[26]

Coppede "Evidence linking genetics, environment, and epigenetics to impaired DNA repair in Alzheimer's disease" J. Alzheimers Dis. (2010) 10.3233/jad-2010-1415

[27]

Counts, S.E., Che, S., Ginsberg, S.D., Mufson, E.J., 2011. Gender differences in neurotrophin and glutamate receptor expression in cholinergic nucleus basalis neurons during the progression of Alzheimer's disease. J. Chem. Neuroanat. [Epub ahead of print], doi:10.1016/j.jchemneu.2011.02.004, this issue. 10.1016/j.jchemneu.2011.02.004

[28]

Counts "Galanin fiber hypertrophy within the cholinergic nucleus basalis during the progression of Alzheimer's disease" Dement. Geriatr. Cogn. Disord. (2006) 10.1159/000090906

[29]

Counts "Galanin hyperinnervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer's disease" Neurodegener. Dis. (2008) 10.1159/000113710

[30]

Counts "Galanin fiber hyperinnervation preserves neuroprotective gene expression in cholinergic basal forebrain neurons in Alzheimer's disease" J. Alzheimers Dis. (2009) 10.3233/jad-2009-1196

[31]

Counts "{alpha}7 Nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease" Arch. Neurol. (2007) 10.1001/archneur.64.12.1771

[32]

Counts "Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease" Ann. Neurol. (2004) 10.1002/ana.20233

[33]

Cowles "The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole" Cell (1997) 10.1016/s0092-8674(01)80013-1

[34]

Cuello "Cholinergic involvement in Alzheimer's disease. A link with NGF maturation and degradation" J. Mol. Neurosci. (2010) 10.1007/s12031-009-9238-z

[35]

Deinhardt "Rab5 and rab7 control endocytic sorting along the axonal retrograde transport pathway" Neuron (2006) 10.1016/j.neuron.2006.08.018

[36]

DeKosky "Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment" Ann. Neurol. (2002) 10.1002/ana.10069

[37]

Devi "Sex- and brain region-specific acceleration of beta-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease" Mol. Brain (2010) 10.1186/1756-6606-3-34

[38]

Eberwine "mRNA expression analysis of tissue sections and single cells" J. Neurosci. (2001) 10.1523/jneurosci.21-21-08310.2001

[39]

Galvin "Expression profiling in the aging brain: a perspective" Ageing Res. Rev. (2005) 10.1016/j.arr.2005.06.009

[40]

Ghidoni, R., Paterlini, A., Albertini, V., Glionna, M., Monti, E., Schiaffonati, L., Benussi, L., Levy, E., Binetti, G., 2009. Cystatin C is released in association with exosomes: a new tool of neuronal communication which is unbalanced in Alzheimer's disease. Neurobiol. Aging. [Epub ahead of print], doi:10.1016/j.neurobiolaging.2009.08.013, in press. 10.1016/j.neurobiolaging.2009.08.013

[41]

Ginsberg "RNA amplification strategies for small sample populations" Methods (2005) 10.1016/j.ymeth.2005.09.003

[42]

Ginsberg "Transcriptional profiling of small samples in the central nervous system" Methods Mol. Biol. (2008) 10.1007/978-1-59745-188-8_10

[43]

Ginsberg, S.D., Alldred, M.J., Che, S. Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease, submitted for publication.

[44]

Ginsberg "Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression" Biol. Psychiatry (2010) 10.1016/j.biopsych.2010.05.030

[45]

Ginsberg "Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease" J. Neurochem. (2006) 10.1111/j.1471-4159.2005.03641.x

[46]

Ginsberg "Single cell gene expression profiling in Alzheimer's disease" NeuroRx (2006) 10.1016/j.nurx.2006.05.007

[47]

Ginsberg "Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease" J. Neurochem. (2006) 10.1111/j.1471-4159.2006.03764.x

[48]

Ginsberg "Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques" Ann. Neurol. (1997) 10.1002/ana.410410211

[49]

Ginsberg "RNA sequestration to pathological lesions of neurodegenerative diseases" Acta Neuropathol. (1998) 10.1007/s004010050923

[50]

Ginsberg "Functional genomic methodologies" Prog. Brain Res. (2006) 10.1016/s0079-6123(06)58002-1

Showing 50 of 96 references

Cited By

121

Rab27-dependent mitochondrial extrusion from dopaminergic neurons drives neuroinflammation and neurodegeneration in the MPTP mouse model of Parkinson's disease

Yingqi Xu, Junyu Li · 2026

Free Radical Biology and Medicine

Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK

Ruth Nussinov, Bengi Ruken Yavuz · 2023

Biophysical Reviews

Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol

Juan Carlos Polanco, Gabriel Rhys Hand · 2021

Acta Neuropathologica

Endo-lysosomal proteins and ubiquitin CSF concentrations in Alzheimer’s and Parkinson’s disease

Simon Sjödin, Gunnar Brinkmalm · 2019

Alzheimer's Research & Therapy

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy

Morvane Colin, Simon Dujardin · 2019

Acta Neuropathologica

Consequences of Rab GTPase dysfunction in genetic or acquired human diseases

Marcellus J. Banworth, Guangpu Li · 2017

Small GTPases

Metrics

121

Citations

96

References

Details

Published: Oct 01, 2011
Vol/Issue: 42(2)
Pages: 102-110
License: View

Authors

S

Stephen D. Ginsberg

Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, USA; Department of Psychiatry, New York University Langone Medical Center, New York, NY, USA; Department of Neuroscience and Physiology, New York University Langone Medical Center, New York, NY, USA

Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, USA; Department of Psychiatry, New York University Langone Medical Center, New York, NY, USA

Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, USA; Department of Psychiatry, New York University Langone Medical Center, New York, NY, USA; Department of Cell Biology, New York University Langone Medical Center, New York, NY, USA

S

Shaoli Che

Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, USA; Department of Psychiatry, New York University Langone Medical Center, New York, NY, USA

Cite This Article

Stephen D. Ginsberg, Elliott J. Mufson, Melissa J. Alldred, et al. (2011). Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. Journal of Chemical Neuroanatomy, 42(2), 102-110. https://doi.org/10.1016/j.jchemneu.2011.05.012

Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease

You May Also Like