journal article Jun 01, 2026

Long-acting triamcinolone acetonide prodrug microcrystals for sustained intra-articular treatment of osteoarthritis

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References
35
[1]
Osteoarthritis

Su'an Tang, Changqing Zhang, Win Min Oo et al.

Nature Reviews Disease Primers 2025 10.1038/s41572-025-00594-6
[2]
Dieppe "Pathogenesis and management of pain in osteoarthritis" Lancet (2005) 10.1016/s0140-6736(05)71086-2
[3]
Haber "When should we treat knee osteoarthritis and with which treatments?" Lancet Rheumatol. (2024) 10.1016/s2665-9913(24)00006-7
[4]
Dell’Isola "Osteoarthritis year in review 2025: epidemiology and therapy" Osteoarthr. Cartil. (2025) 10.1016/j.joca.2025.08.015
[5]
Evans "Progress in intra-articular therapy" Nat. Rev. Rheumatol. (2014) 10.1038/nrrheum.2013.159
[6]
Jones "Intra-articular treatment options for knee osteoarthritis" Nat. Rev. Rheumatol. (2019) 10.1038/s41584-018-0123-4
[7]
Oshima "The comparison of dexamethasone and triamcinolone periarticular administration in total knee arthroplasty: retrospective cohort study" BMC Musculoskelet. Disord. (2022) 10.1186/s12891-022-05048-8
[8]
Russell "Triamcinolone acetonide extended-release in patients with osteoarthritis and type 2 diabetes: a randomized, phase 2 study" Rheumatology (Oxford) (2018) 10.1093/rheumatology/key265
[9]
Bensa "Intra-articular corticosteroids for the treatment of osteoarthritis: a systematic review and meta-analysis on the comparison of different molecules and doses" J. Exp. Orthop. (2024) 10.1002/jeo2.12060
[10]
Paik "Triamcinolone acetonide extended-release: a review in osteoarthritis pain of the knee" Drugs (2019) 10.1007/s40265-019-01083-3
[11]
Bodick "An intra-articular, extended-release formulation of triamcinolone acetonide prolongs and amplifies analgesic effect in patients with osteoarthritis of the knee: a randomized clinical trial" J. Bone Joint Surg. (2015) 10.2106/jbjs.n.00918
[12]
Conaghan "Brief report: a phase IIb trial of a novel extended-release microsphere formulation of triamcinolone acetonide for intraarticular injection in knee osteoarthritis" Arthritis Rheum. (2018) 10.1002/art.40364
[13]
Thackaberry "Evaluation of the toxicity of intravitreally injected PLGA microspheres and rods in monkeys and rabbits: effects of depot size on inflammatory response" Invest. Ophthalmol. Vis. Sci. (2017) 10.1167/iovs.16-21334
[14]
Siefen "Assessment of joint pharmacokinetics and consequences for the intraarticular delivery of biologics" J. Control. Release (2022) 10.1016/j.jconrel.2022.06.015
[15]
Tessier "Emerging nanoparticle platforms to improve the administration of glucocorticoids" J. Control. Release (2023) 10.1016/j.jconrel.2023.04.039
[16]
Deng "Chondrocyte membrane-coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis" Sci. Transl. Med. (2024) 10.1126/scitranslmed.adh9751
[17]
Chien "Prodrug approaches for the development of a long-acting drug delivery systems" Adv. Drug Deliv. Rev. (2023) 10.1016/j.addr.2023.114860
[18]
Storgaard "Diclofenac Prodrugs for Intra-articular Depot Injectables: In Vitro Hydrolysis and Species Variation" J. Pharm. Sci. (2020) 10.1016/j.xphs.2020.01.003
[19]
Thing "Simulated synovial fluids for in vitro drug and prodrug release testing of depot injectables intended for joint injection" J. Drug Delivery Sci. Technol. (2019) 10.1016/j.jddst.2018.11.012
[20]
Alidori "Patient-centric long-acting injectable and implantable platformsan industrial perspective" Mol. Pharm. (2024) 10.1021/acs.molpharmaceut.4c00665
[21]
Joint Acidosis and Acid-Sensing Receptors and Ion Channels in Osteoarthritis Pathobiology and Therapy

William N. Martin, Colette Hyde, Adam Yung et al.

Cells 2025 10.3390/cells14201605
[22]
Lombardi "AcidoCEST-UTE MRI reveals an acidic microenvironment in knee osteoarthritis" Int. J. Mol. Sci. (2022) 10.3390/ijms23084466
[23]
Zhou "Subconjunctival injection of microcrystalline prodrug of dexamethasone for long-acting anti-inflammation after phacoemulsification surgery" J. Control. Release (2025) 10.1016/j.jconrel.2024.11.046
[24]
Zhao "Advances in acid-degradable and enzyme-cleavable linkers for drug delivery" Curr. Opin. Chem. Biol. (2025) 10.1016/j.cbpa.2024.102552
[25]
Yu "Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols" Nat. Commun. (2021) 10.1038/s41467-021-25856-1
[26]
Sodeifian "Solubility measurement of triamcinolone acetonide (steroid medication) in supercritical CO2: experimental and thermodynamic modeling" J. Supercrit. Fluids (2024) 10.1016/j.supflu.2023.106119
[27]
Xu "Microcrystals of ketal-linked paliperidone prodrugs for long-acting antipsychotics" Mol. Pharm. (2022) 10.1021/acs.molpharmaceut.2c00348
[28]
Liu "Simultaneous determination of triamcinolone acetonide palmitate and triamcinolone acetonide in beagle dog plasma by UPLC-MS/MS and its application to a long-term pharmacokinetic study of triamcinolone acetonide palmitate lipid emulsion injection" J. Pharm. Biomed. Anal. (2015) 10.1016/j.jpba.2014.11.028
[29]
Heffernan "Polyketal nanoparticles: a new pH-sensitive biodegradable drug delivery vehicle" Bioconjug. Chem. (2005) 10.1021/bc050176w
[30]
Kurono "Esterase-like activity of human serum albumin. VIII. Reaction with amino acid p-nitrophenyl esters" Chem. Pharm. Bull. (1992) 10.1248/cpb.40.2169
[31]
Westhof "Dynamic weight-bearing test during jumping: a sensitive outcome measure of chronic osteoarthritis pain in rats" Heliyon (2021) 10.1016/j.heliyon.2021.e07906
[32]
Kroin "Intraarticular slow-release triamcinolone acetate reduces allodynia in an experimental mouse knee osteoarthritis model" Gene (2016) 10.1016/j.gene.2016.06.049
[33]
Hu "Overview of MMP-13 as a promising target for the treatment of osteoarthritis" Int. J. Mol. Sci. (2021) 10.3390/ijms22041742
[34]
Teng "Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo" Chin. J. Nat. Med. (2023)
[35]
Han "Association between knee alignment, osteoarthritis disease severity, and subchondral trabecular bone microarchitecture in patients with knee osteoarthritis: a cross-sectional study" Arthritis Res. Ther. (2020) 10.1186/s13075-020-02274-0
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Published
Jun 01, 2026
Vol/Issue
394
Pages
114868
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Funding
National Natural Science Foundation of China
Cite This Article
Xiaoyu Wang, Yanliang Dong, Xiaofeng Lin, et al. (2026). Long-acting triamcinolone acetonide prodrug microcrystals for sustained intra-articular treatment of osteoarthritis. Journal of Controlled Release, 394, 114868. https://doi.org/10.1016/j.jconrel.2026.114868
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