Mechanistic insights into novel triclosan target pathways in Neocaridina denticulata revealed by multi-omics integration

Sang-Eun Nam; Seongmin Cheon; Somyeong Lee; Dae-Yeul Bae; Tae-Yong Jeong; Dohyun Han; Jae-Sung Rhee

doi:10.1016/j.jhazmat.2026.141856

journal article May 01, 2026

Mechanistic insights into novel triclosan target pathways in Neocaridina denticulata revealed by multi-omics integration

Sang-Eun Nam Seongmin Cheon

Somyeong Lee Dae-Yeul Bae Tae-Yong Jeong Dohyun Han

Jae-Sung Rhee

Journal of Hazardous Materials Vol. 508 pp. 141856 · Elsevier BV

View at Publisher Save 10.1016/j.jhazmat.2026.141856

Topics

No keywords indexed for this article. Browse by subject →

References

62

[1]

Dar "Source, bioaccumulation, degradability and toxicity of triclosan in aquatic environments: a review" Environ Technol Innov (2022) 10.1016/j.eti.2021.102122

[2]

Heath "Mechanism of triclosan inhibition of bacterial fatty acid synthesis" J Biol Chem (1999) 10.1074/jbc.274.16.11110

[3]

Kolpin "Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999− 2000: a national reconnaissance" Environ Sci Technol (2002) 10.1021/es011055j

[4]

Dhillon "Triclosan: current status, occurrence, environmental risks and bioaccumulation potential" Int J Environ Res Public Health (2015) 10.3390/ijerph120505657

[5]

U.S. Food and Drug Administration (FDA), 2017, Safety and Effectiveness of Health Care Antiseptics; Topical Antimicrobial Drug Products for Over-the-Counter Human Use, 21 CFR Part 310. Available at: 〈https://www.govinfo.gov/content/pkg/FR-2017-12-20/pdf/2017-27317.pdf〉.

[6]

Ministry of Food and Drug Safety (MFDS), 2026. Press release: Detection of triclosan in toothpaste and other consumer products. Ministry of Food and Drug Safety, Cheongju, Republic of Korea. Available at: 〈https://www.mfds.go.kr/brd/m_99/view.do?seq=49641〉 (Accessed Feburary 13, 2026).

[7]

Zhang "Hidden threats: occurrence, distribution, environmental burdens, and exposure risks of parabens and triclosan in sanitary napkins from China" Hum Ecol Risk Assess (2025) 10.1080/10807039.2025.2574269

[8]

Moazeni "Human health risk assessment of Triclosan in water: spatial analysis of a drinking water system" Environ Monit Assess (2023) 10.1007/s10661-023-11789-3

[9]

Kumar "Ecotoxicological risk assessment of triclosan, an emerging pollutant in a riverine and estuarine ecosystems: a comparative study" Mar Pollut Bull (2024) 10.1016/j.marpolbul.2024.116667

[10]

Wang "Unveiling the occurrence and ecological risks of triclosan in surface water through meta-analysis" Environ Pollut (2024) 10.1016/j.envpol.2024.124901

[11]

Dann "Triclosan: environmental exposure, toxicity and mechanisms of action" J Appl Toxicol (2011) 10.1002/jat.1660

[12]

Do "Acute and chronic effects of triclosan on the behavior, physiology, and multigenerational characteristics of the water flea Moina macrocopa" Comp Biochem Physiol C (2024)

[13]

Kumar "Biomarkers-based assessment of triclosan toxicity in aquatic environment: a mechanistic review" Environ Pollut (2021) 10.1016/j.envpol.2021.117569

[14]

Lushchak "Environmentally induced oxidative stress in aquatic animals" Aquat Toxicol (2011) 10.1016/j.aquatox.2010.10.006

[15]

Wu "Glutathione metabolism and its implications for health" J Nutr (2004) 10.1093/jn/134.3.489

[16]

Taylor "Beyond the human genome project: the age of complete human genome sequences and pangenome references" Annu Rev Genom Hum Genet (2024) 10.1146/annurev-genom-021623-081639

[17]

Chen "Applications of multi-omics analysis in human diseases" MedComm (2023) 10.1002/mco2.315

[18]

Baysoy "The technological landscape and applications of single-cell multi-omics" Nat Rev Mol Cell Biol (2023) 10.1038/s41580-023-00615-w

[19]

Nam "The importance of multi-omics approaches for the health assessment of freshwater ecosystems" Mol Cell Toxicol (2023) 10.1007/s13273-022-00286-2

[20]

Klaine "Nanomaterials in the environment: behavior, fate, bioavailability, and effects" Environ Toxicol Chem (2008) 10.1897/08-090.1

[21]

Zhang "Animal biodiversity: An outline of higher-level classification and survey of taxonomic richness" Zootaxa (2011)

[22]

Kenny "Genomic sequence and experimental tractability of a new decapod shrimp model, Neocaridina denticulata" Mar Drugs (2014) 10.3390/md12031419

[23]

Mocq "Rank ordering of species sensitivities to chemicals: discrepancies between behavioral and lethal responses in freshwater and marine invertebrates" Environ Sci Technol (2025) 10.1021/acs.est.5c04457

[24]

Antil "DNA barcoding, an effective tool for species identification: a review" Mol Biol Rep (2023) 10.1007/s11033-022-08015-7

[25]

Hebert "Biological identifications through DNA barcodes" Proc R Soc Lond Ser B-Biol Sci (2003)

[26]

OECD, 2004. Test No. 202: Daphnia sp. Acute Immobilisation Test.

[27]

Won "Molecular evidence for suppression of swimming behavior and reproduction in the estuarine rotifer Brachionus koreanus in response to COVID-19 disinfectants" Mar Pollut Bull (2022) 10.1016/j.marpolbul.2022.113396

[28]

Nam "Multi-omics integration reveals underlying toxicological mechanisms of triclosan in the freshwater fish model Zacco platypus" Aquat Toxicol (2025) 10.1016/j.aquatox.2025.107522

[29]

Bushnell "BBMerge–accurate paired shotgun read merging via overlap" PLoS One (2017) 10.1371/journal.pone.0185056

[30]

Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences

Weizhong Li, Adam Godzik

Bioinformatics 2006 10.1093/bioinformatics/btl158

[31]

Buchfink "Sensitive protein alignments at tree-of-life scale using DIAMOND" Nat Methods (2021) 10.1038/s41592-021-01101-x

[32]

Gene Ontology: tool for the unification of biology

Michael Ashburner, Catherine A. Ball, Judith A. Blake et al.

Nature Genetics 2000 10.1038/75556

[33]

High-throughput functional annotation and data mining with the Blast2GO suite

S. Gotz, J. M. Garcia-Gomez, J. Terol et al.

Nucleic Acids Research 2008 10.1093/nar/gkn176

[34]

Moriya "KAAS: an automatic genome annotation and pathway reconstruction server" Nucleic Acids Res (2007) 10.1093/nar/gkm321

[35]

Fast gapped-read alignment with Bowtie 2

Ben Langmead, Steven L Salzberg

Nature Methods 2012 10.1038/nmeth.1923

[36]

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

Bo Li, Colin N Dewey

BMC Bioinformatics 2011 10.1186/1471-2105-12-323

[37]

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I Love, Wolfgang Huber, Simon Anders

Genome Biology 2014 10.1186/s13059-014-0550-8

[38]

Wiśniewski "Fast and sensitive total protein and peptide assays for proteomic analysis" Anal Chem (2015) 10.1021/ac504689z

[39]

Cha "Discovery of proteins responsible for resistance to three chemotherapy drugs in breast cancer cells using proteomics and bioinformatics analysis" Molecules (2022) 10.3390/molecules27061762

[40]

R. Core Team, 2023. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria.

[41]

Welcome to the Tidyverse

Hadley Wickham, Mara Averick, Jennifer Bryan et al.

The Journal of Open Source Software 2019 10.21105/joss.01686

[42]

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie, Belinda Phipson, Di Wu et al.

Nucleic Acids Research 2015 10.1093/nar/gkv007

[43]

Pang "MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation" Nucleic Acids Res (2024) 10.1093/nar/gkae253

[44]

Rohart "mixOmics: an R package for ‘omics feature selection and multiple data integration" PLoS Comput Biol (2017) 10.1371/journal.pcbi.1005752

[45]

Yu "clusterProfiler: an R package for comparing biological themes among gene clusters" OMICS J Integr Biol (2012) 10.1089/omi.2011.0118

[46]

Doncheva "Cytoscape StringApp: network analysis and visualization of proteomics data" J Proteome Res (2018) 10.1021/acs.jproteome.8b00702

[47]

Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks

Paul Shannon, Andrew Markiel, Owen Ozier et al.

Genome Research 2003 10.1101/gr.1239303

[48]

A Set of Measures of Centrality Based on Betweenness

Linton C. Freeman

Sociometry 1977 10.2307/3033543

[49]

Yu Tang "CytoNCA: a cytoscape plugin for centrality analysis and evaluation of biological networks" BioSystems (2014)

[50]

Chiara "AnimalTA: a highly flexible and easy-to-use program for tracking and analysing animal movement in different environments" Methods Ecol Evol (2023) 10.1111/2041-210x.14115

Showing 50 of 62 references

Metrics

0

Citations

62

References

Details

Published: May 01, 2026
Vol/Issue: 508
Pages: 141856
License: View

Authors

Funding

National Research Foundation of Korea

Cite This Article

Sang-Eun Nam, Seongmin Cheon, Somyeong Lee, et al. (2026). Mechanistic insights into novel triclosan target pathways in Neocaridina denticulata revealed by multi-omics integration. Journal of Hazardous Materials, 508, 141856. https://doi.org/10.1016/j.jhazmat.2026.141856

Mechanistic insights into novel triclosan target pathways in Neocaridina denticulata revealed by multi-omics integration

You May Also Like