Exercise and Sedentary Behavior Do Not Alter Lung or Liver Metastases in a Murine Colon Cancer Model

Mylena D. Bos; Cassandra S.L. Ho; N. Helge Meyer; Maximilian Bockhorn; Frank A.E. Kruyt; Joost M. Klaase; Frederik J.H. Hoogwater; Maarten W. Nijkamp

doi:10.1016/j.jss.2026.02.023

journal article Open Access May 01, 2026

Exercise and Sedentary Behavior Do Not Alter Lung or Liver Metastases in a Murine Colon Cancer Model

Mylena D. Bos

Cassandra S.L. Ho N. Helge Meyer Maximilian Bockhorn

Frank A.E. Kruyt Joost M. Klaase Frederik J.H. Hoogwater Maarten W. Nijkamp

Journal of Surgical Research Vol. 321 pp. 143-153 · Elsevier BV

View at Publisher Save 10.1016/j.jss.2026.02.023

Topics

No keywords indexed for this article. Browse by subject →

References

54

[1]

McTiernan "Physical activity in cancer prevention and survival: a systematic review" Med Sci Sports Exerc (2019) 10.1249/mss.0000000000001937

[2]

Friedenreich "Physical activity, obesity and sedentary behavior in cancer etiology: epidemiologic evidence and biologic mechanisms" Mol Oncol (2021) 10.1002/1878-0261.12772

[3]

Goh "Exercise training in transgenic mice is associated with attenuation of early breast cancer growth in a dose-dependent manner" PLoS One (2013) 10.1371/journal.pone.0080123

[4]

Higgins "Exercise-induced lung cancer regression: mechanistic findings from a mouse model" Cancer (2014) 10.1002/cncr.28878

[5]

Pedersen "Voluntary running suppresses tumor growth through Epinephrine- and IL-6-Dependent NK cell mobilization and redistribution" Cell Metab (2016) 10.1016/j.cmet.2016.01.011

[6]

Tobias "Aerobic exercise training mitigates tumor growth and cancer-induced splenomegaly through modulation of non-platelet platelet factor 4 expression" Sci Rep (2023) 10.1038/s41598-023-47217-2

[7]

Esteves "Regular voluntary running is associated with increased tumor vascularization and immune cell infiltration and decreased tumor growth in mice" Int J Sports Med (2023) 10.1055/a-2008-7732

[8]

Cormie "The impact of exercise on cancer mortality, recurrence, and treatment-related adverse effects" Epidemiol Rev (2017) 10.1093/epirev/mxx007

[9]

Friedenreich "Physical activity and mortality in cancer survivors: a systematic review and meta-analysis" JNCI Cancer Spectr (2020) 10.1093/jncics/pkz080

[10]

Kerr "Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence" Lancet Oncol (2017) 10.1016/s1470-2045(17)30411-4

[11]

Jochem "The influence of sedentary behavior on cancer risk: Epidemiologic evidence and potential molecular mechanisms" Curr Nutr Rep (2019) 10.1007/s13668-019-0263-4

[12]

Hermelink "Sedentary behavior and cancer-an umbrella review and meta-analysis" Eur J Epidemiol (2022) 10.1007/s10654-022-00873-6

[13]

Bull "World Health Organization 2020 guidelines on physical activity and sedentary behaviour" Br J Sports Med (2020) 10.1136/bjsports-2020-102955

[14]

Hojman "Molecular mechanisms linking exercise to cancer prevention and treatment" Cell Metab (2018) 10.1016/j.cmet.2017.09.015

[15]

Jia "The antitumor mechanisms of aerobic exercise: a review of recent preclinical studies" Cancer Med (2021) 10.1002/cam4.4169

[16]

Esteves "Role of regular physical exercise in tumor vasculature: favorable modulator of tumor milieu" Int J Sports Med (2021) 10.1055/a-1308-3476

[17]

Ashcraft "Efficacy and mechanisms of aerobic exercise on cancer initiation, progression, and metastasis: a critical systematic review of in vivo preclinical data" Cancer Res (2016) 10.1158/0008-5472.can-16-0887

[18]

Rincon-Castanedo "Physical exercise effects on metastasis: a systematic review and meta-analysis in animal cancer models" Cancer Metastasis Rev (2020) 10.1007/s10555-020-09851-4

[19]

Hoffmann-Goetz "Tissue distribution of radiolabelled tumor cells in wheel exercised and sedentary mice" Int J Sports Med (1994) 10.1055/s-2007-1021055

[20]

Sheinboim "An exercise-induced metabolic shield in distant organs blocks cancer progression and metastatic dissemination" Cancer Res (2022) 10.1158/0008-5472.can-22-0237

[21]

Yan "Effects of non-motorized voluntary running on experimental and spontaneous metastasis in mice" Anticancer Res (2011)

[22]

Alvarado "Effects of exercise training on breast cancer metastasis in a rat model" Int J Exp Pathol (2017) 10.1111/iep.12225

[23]

Zhang "Moderate swimming suppressed the growth and metastasis of the transplanted liver cancer in mice model: with reference to nervous system" Oncogene (2016) 10.1038/onc.2015.484

[24]

Smeda "Breast cancer pulmonary metastasis is increased in mice undertaking spontaneous physical training in the running wheel; a call for revising beneficial effects of exercise on cancer progression" Am J Cancer Res (2017)

[25]

Pernold "Towards large scale automated cage monitoring - diurnal rhythm and impact of interventions on in-cage activity of C57BL/6J mice recorded 24/7 with a non-disrupting capacitive-based technique" PLoS One (2019) 10.1371/journal.pone.0211063

[26]

Smakman "Validation of bioluminescence imaging of colorectal liver metastases in the mouse" J Surg Res (2004) 10.1016/j.jss.2004.05.021

[27]

Kanoh "Antitumor effect of a splenic injection of 5-fluorouracil on metastatic liver cancer in mice" J Pharmacol Exp Ther (2004) 10.1124/jpet.103.057547

[28]

Yang "Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages and neovascularization" Int J Cancer (2006) 10.1002/ijc.21371

[29]

Cambien "Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism" Br J Cancer (2009) 10.1038/sj.bjc.6605078

[30]

van Eenige "RandoMice, a novel, user-friendly randomization tool in animal research" PLoS One (2020) 10.1371/journal.pone.0237096

[31]

Moraska "Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats" Am J Physiol Regul Integr Comp Physiol (2000) 10.1152/ajpregu.2000.279.4.r1321

[32]

Svensson "Forced treadmill exercise can induce stress and increase neuronal damage in a mouse model of global cerebral ischemia" Neurobiol Stress (2016) 10.1016/j.ynstr.2016.09.002

[33]

He "Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment" Cancer Cell (2024) 10.1016/j.ccell.2024.01.013

[34]

Inducing Physical Inactivity in Mice: Preventing Climbing and Reducing Cage Size Negatively Affect Physical Fitness and Body Composition

Peter Roemers, Yasmin Hulst, Steffen van Heijningen et al.

Frontiers in Behavioral Neuroscience 2019 10.3389/fnbeh.2019.00221

[35]

Alabi "Novel sedentary cage induced sedentariness in rats: evidence from relevant biomarkers" BMC Endocr Disord (2022) 10.1186/s12902-022-01221-1

[36]

Siripoksup "Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism" J Clin Invest (2024) 10.1172/jci167371

[37]

Neophytou "The role of tumor microenvironment in cancer metastasis: molecular mechanisms and therapeutic opportunities" Cancers (Basel) (2021) 10.3390/cancers13092053

[38]

de Visser "The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth" Cancer Cell (2023) 10.1016/j.ccell.2023.02.016

[39]

Lugano "Tumor angiogenesis: causes, consequences, challenges and opportunities" Cell Mol Life Sci (2020) 10.1007/s00018-019-03351-7

[40]

Rankin "Hypoxia: signaling the metastatic Cascade" Trends Cancer (2016) 10.1016/j.trecan.2016.05.006

[41]

Chen "Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions" Signal Transduct Target Ther (2023) 10.1038/s41392-023-01332-8

[42]

Schadler "Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy" Oncotarget (2016) 10.18632/oncotarget.11748

[43]

Rundqvist "Cytotoxic T-cells mediate exercise-induced reductions in tumor growth" Elife (2020) 10.7554/elife.59996

[44]

Voltarelli "Moderate-intensity aerobic exercise training improves CD8(+) tumor-infiltrating lymphocytes effector function by reducing mitochondrial loss" iScience (2024) 10.1016/j.isci.2024.110121

[45]

Brown "Effects of exercise on circulating tumor cells among patients with resected stage I-III colon cancer" PLoS One (2018) 10.1371/journal.pone.0204875

[46]

Jee "Positive prehabilitative effect of intense treadmill exercise for ameliorating cancer Cachexia symptoms in a mouse model" J Cancer (2016) 10.7150/jca.17162

[47]

Wijler "Voluntary exercise influences metastatic organotropism in a murine colorectal cancer model" JCSM Rapid Commun (2022) 10.1002/rco2.51

[48]

van der Bilt "Ageing and hepatic steatosis exacerbate ischemia/reperfusion-accelerated outgrowth of colorectal micrometastases" Ann Surg Oncol (2008) 10.1245/s10434-007-9758-0

[49]

Ray "The role of sex in the innate and adaptive immune environment of metastatic colorectal cancer" Br J Cancer (2020) 10.1038/s41416-020-0913-8

[50]

Geddes "An analysis of sexual dimorphism in the tumor microenvironment of colorectal cancer" Front Oncol (2022) 10.3389/fonc.2022.986103

Showing 50 of 54 references

Metrics

0

Citations

54

References

Details

Published: May 01, 2026
Vol/Issue: 321
Pages: 143-153
License: View

Authors

Frederik J.H. Hoogwater

M

Maarten W. Nijkamp

Funding

Rijksuniversiteit Groningen

Cite This Article

Mylena D. Bos, Cassandra S.L. Ho, N. Helge Meyer, et al. (2026). Exercise and Sedentary Behavior Do Not Alter Lung or Liver Metastases in a Murine Colon Cancer Model. Journal of Surgical Research, 321, 143-153. https://doi.org/10.1016/j.jss.2026.02.023

Exercise and Sedentary Behavior Do Not Alter Lung or Liver Metastases in a Murine Colon Cancer Model

You May Also Like