Role of NAD+ in regulating cellular and metabolic signaling pathways

Heikal "Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies" Biomarkers in Medicine (2010) 10.2217/bmm.10.1

[4]

Trisolini "FAD/NADH dependent oxidoreductases: from different amino acid sequences to similar protein shapes for playing an ancient function" Journal of Clinical Medicine (2019) 10.3390/jcm8122117

[5]

NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

Na Xie, Lu Zhang, Wei Gao et al.

Signal Transduction and Targeted Therapy 2020 10.1038/s41392-020-00311-7

[6]

Wallace "Mitochondria and cancer" Nature Reviews Cancer (2012) 10.1038/nrc3365

[7]

Ying "NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences" Antioxidants and Redox Signaling (2008) 10.1089/ars.2007.1672

[8]

Pehar "Nicotinamide adenine dinucleotide metabolism and neurodegeneration" Antioxidants and Redox Signaling (2018) 10.1089/ars.2017.7145

[9]

Demarest "NAD+ metabolism in aging and cancer" Annual Review of Cancer Biology (2019) 10.1146/annurev-cancerbio-030518-055905

[10]

Nikiforov "The human NAD metabolome: functions, metabolism and compartmentalization" Critical Reviews in Biochemistry and Molecular Biology (2015) 10.3109/10409238.2015.1028612

[11]

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Luis Rajman, Karolina Chwalek, David A. Sinclair

Cell Metabolism 2018 10.1016/j.cmet.2018.02.011

[12]

Aman "Therapeutic potential of boosting NAD+ in aging and age-related diseases" Translational Medicine of Aging (2018) 10.1016/j.tma.2018.08.003

[13]

Lau "The NMN/NaMN adenylyltransferase (NMNAT) protein family" Frontiers in Bioscience (2009) 10.2741/3252

[14]

Emanuelli "Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase" Journal of Biological Chemistry (2001) 10.1074/jbc.m008700200

[15]

Yalowitz "Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas" Biochemical Journal (2004) 10.1042/bj20030518

[16]

Berger "Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms" Journal of Biological Chemistry (2005) 10.1074/jbc.m508660200

[17]

Raffaelli "Identification of a novel human nicotinamide mononucleotide adenylyltransferase" Biochemical and Biophysical Research Communications (2002) 10.1016/s0006-291x(02)02285-4

[18]

Hikosaka "Deficiency of nicotinamide mononucleotide adenylyltransferase 3 (nmnat3) causes hemolytic anemia by altering the glycolytic flow in mature erythrocytes" Journal of Biological Chemistry (2014) 10.1074/jbc.m114.554378

[19]

Yang "Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival" Cell (2007) 10.1016/j.cell.2007.07.035

[20]

Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells

Andrey Nikiforov, Christian Dölle, Marc Niere et al.

Journal of Biological Chemistry 2011 10.1074/jbc.m110.213298

[21]

Marletta "Crystal structure of human nicotinic acid phosphoribosyltransferase" FEBS Open Bio (2015) 10.1016/j.fob.2015.05.002

[22]

NAD+ metabolism in health and disease

Peter Belenky, Katrina L. Bogan, Charles Brenner

Trends in Biochemical Sciences 2007 10.1016/j.tibs.2006.11.006

[23]

Magni "Enzymology of NAD+ homeostasis in man" Cellular and Molecular Life Sciences (2004) 10.1007/s00018-003-3161-1

[24]

Houtkooper "The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways" Endocrine Reviews (2010) 10.1210/er.2009-0026

[25]

Kulkarni "Cellular compartmentation and the redox/non-redox functions of NAD+" Antioxidants and Redox Signaling (2019) 10.1089/ars.2018.7722

[26]

Katsyuba "De novo NAD(+) synthesis enhances mitochondrial function and improves health" Nature (2018) 10.1038/s41586-018-0645-6

[27]

NNMT activation can contribute to the development of fatty liver disease by modulating the NAD + metabolism

Motoaki Komatsu, Takeshi Kanda, Hidenori Urai et al.

Scientific Reports 2018 10.1038/s41598-018-26882-8

[28]

Kellenberger "Flavonoids as inhibitors of human CD38" Bioorganic & Medicinal Chemistry Letters (2011) 10.1016/j.bmcl.2011.05.022

[29]

Tarragó "A potent and specific CD38 inhibitor ameliorates age-related metabolic dysfunction by reversing tissue NAD(+) decline" Cell Metabolism (2018) 10.1016/j.cmet.2018.03.016

[30]

Escande "Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome" Diabetes (2013) 10.2337/db12-1139

[31]

Boslett "Luteolinidin protects the postischemic heart through CD38 inhibition with preservation of NAD(P)(H)" Journal of Pharmacology and Experimental Therapeutics (2017) 10.1124/jpet.116.239459

[32]

Mouchiroud "NAD+ metabolism: a therapeutic target for age-related metabolic disease" Critical Reviews in Biochemistry and Molecular Biology (2013) 10.3109/10409238.2013.789479

[33]

Pirinen "Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle" Cell Metabolism (2014) 10.1016/j.cmet.2014.04.002

[34]

Slade "PARP and PARG inhibitors in cancer treatment" Genes & Development (2020) 10.1101/gad.334516.119

[35]

Baldwin "Nanoformulation of talazoparib increases maximum tolerated doses in combination with Temozolomide for treatment of Ewing sarcoma" Frontiers in Oncology (2019) 10.3389/fonc.2019.01416

[36]

Zha "PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity" Stem Cell Research & Therapy (2018) 10.1186/s13287-018-0961-7

[37]

Almeida "PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS" NMR in Biomedicine (2017) 10.1002/nbm.3736

[38]

Cohen "Interplay between compartmentalized NAD(+) synthesis and consumption: a focus on the PARP family" Genes & Development (2020) 10.1101/gad.335109.119

[39]

McReynolds "Age-related NAD(+) decline" Experimental Gerontology (2020) 10.1016/j.exger.2020.110888

[40]

Mills "Long-Term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice" Cell Metabolism (2016) 10.1016/j.cmet.2016.09.013

[41]

Zhang "NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice" Science (2016) 10.1126/science.aaf2693

[42]

Parker "Age-related adverse inflammatory and metabolic changes begin early in adulthood" Journals of Gerontology Series A: Biological and Medical Sciences (2019) 10.1093/gerona/gly121

[43]

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon et al.

Cell Metabolism 2011 10.1016/j.cmet.2011.08.014

[44]

Yoshino "NAD(+) intermediates: the biology and therapeutic potential of NMN and NR" Cell Metabolism (2018) 10.1016/j.cmet.2017.11.002

[45]

Ramsey "Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice" Aging Cell (2008) 10.1111/j.1474-9726.2007.00355.x

[46]

Thompson "Chromosomes and cancer cells" Chromosome Research : An International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology (2011) 10.1007/s10577-010-9179-y

[47]

Ramis "Caloric restriction, resveratrol and melatonin: role of SIRT1 and implications for aging and related-diseases" Mechanism of Ageing and Development (2015) 10.1016/j.mad.2015.03.008

[48]

Fritze "Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA" The EMBO Journal (1997) 10.1093/emboj/16.21.6495

[49]

Bryan "Redox-inflammatory synergy in the metabolic syndrome" Canadian Journal of Physiology and Pharmacology (2013) 10.1139/cjpp-2012-0295

[50]

Jin "Modern biological theories of aging" Aging and Disease (2010)

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Details

Published: Jul 01, 2021
Vol/Issue: 49
Pages: 101195
License: View

Authors

Epigenetics Cardiovascular Laboratory, Department of Genetic Medicine, Weill Cornell Medicine-Qatar, PO box 24144, Doha, Qatar; Department of Human Genetics, Sidra Medical & Research Centre, PO box 26999, Doha, Qatar

Funding

NIDDK

Cite This Article

Sara Amjad, Sabah Nisar, Ajaz A. Bhat, et al. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular Metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195

Role of NAD+ in regulating cellular and metabolic signaling pathways

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