journal article
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Nov 01, 2024
Astrocyte-derived lactoferrin inhibits neuronal ferroptosis by reducing iron content and GPX4 degradation in APP/PS1 transgenic mice
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References
43
[1]
Kenkhuis "How iron can drive neurodegeneration" Trends Neurosci. (2023) 10.1016/j.tins.2023.02.003
[2]
Kuchcinski "Quantitative susceptibility mapping demonstrates different patterns of iron overload in subtypes of early-onset Alzheimer's disease" Eur. Radio. (2023) 10.1007/s00330-022-09014-9
[3]
Viswanathan "Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway" Nature (2017) 10.1038/nature23007
[4]
Yan "Ferroptosis: mechanisms and links with diseases" Signal Transduct. Target Ther. (2021) 10.1038/s41392-020-00428-9
[5]
Wang "CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy." Nature (2019) 10.1038/s41586-019-1170-y
[6]
Bersuker "The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis" Nature (2019) 10.1038/s41586-019-1705-2
[7]
Hambright "Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration" Redox Biol. (2017) 10.1016/j.redox.2017.01.021
[8]
Bao "Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease" Cell Death Differ. (2021) 10.1038/s41418-020-00685-9
[9]
Moorthy "Polycatechols inhibit ferroptosis and modulate tau liquid-liquid phase separation to mitigate Alzheimer's disease" Mater. Horiz. (2024) 10.1039/d4mh00023d
[10]
Padhi "Hybrid molecules synergistically mitigate ferroptosis and amyloid-associated toxicities in Alzheimer's disease" Redox Biol. (2024) 10.1016/j.redox.2024.103119
[11]
Baker "Lactoferrin and iron: structural and dynamic aspects of binding and release" Biometals (2004) 10.1023/b:biom.0000027694.40260.70
[12]
Kawamata "Lactotransferrin immunocytochemistry in Alzheimer and normal human brain" Am. J. Pathol. (1993)
[13]
Leveugle "The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis" Brain Res (1994) 10.1016/0006-8993(94)90202-x
[14]
Carro "Early diagnosis of mild cognitive impairment and Alzheimer's disease based on salivary lactoferrin" Alzheimers Dement (Amst. (2017) 10.1016/j.dadm.2017.04.002
[15]
Guo "Intranasal Lactoferrin Enhances alpha-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1alpha Pathways in an Alzheimer's Disease Mouse Model" Neuropsychopharmacology (2017) 10.1038/npp.2017.8
[16]
Tsatsanis "The acute phase protein lactoferrin is a key feature of Alzheimer's disease and predictor of Abeta burden through induction of APP amyloidogenic processing." Mol. Psychiatry (2021) 10.1038/s41380-021-01248-1
[17]
Fan "Astrocyte-derived lactoferrin reduces beta-amyloid burden by promoting the interaction between p38 kinase and PP2A phosphatase in male APP/PS1 transgenic mice" Br. J. Pharm. (2024) 10.1111/bph.16161
[18]
Xiao "Reduction of lactoferrin aggravates neuronal ferroptosis after intracerebral hemorrhagic stroke in hyperglycemic mice" Redox Biol. (2022) 10.1016/j.redox.2022.102256
[19]
Tindall "LRP1 is the cell-surface endocytosis receptor for vaspin in adipocytes" FEBS J. (2023) 10.1111/febs.16991/v2/response1
[20]
Chen "LRP1 is a neuronal receptor for alpha-synuclein uptake and spread" Mol. Neurodegener. (2022) 10.1186/s13024-022-00560-w
[21]
Galey "N,N′-bis-dibenzyl ethylenediaminediacetic acid (DBED): a site-specific hydroxyl radical scavenger acting as an "oxidative stress activatable" iron chelator in vitro" Free Radic. Res (1995) 10.3109/10715769509147529
[22]
Wang "A novel Fe3+ fluorescent probe based on rhodamine derivatives and its application in biological imaging" J. Mol. Struct. (2022) 10.1016/j.molstruc.2022.133979
[23]
Wu "Activation of vitamin D receptor inhibits Tau phosphorylation is associated with reduction of iron accumulation in APP/PS1 transgenic mice" Neurochem Int (2022) 10.1016/j.neuint.2021.105260
[24]
Wu "Chaperone-mediated autophagy is involved in the execution of ferroptosis" Proc. Natl. Acad. Sci. USA (2019) 10.1073/pnas.1819728116
[25]
Kaushik "Chaperone-mediated autophagy: a unique way to enter the lysosome world" Trends Cell Biol. (2012) 10.1016/j.tcb.2012.05.006
[26]
Abdelhamid "Dietary Lactoferrin Supplementation Prevents Memory Impairment and Reduces Amyloid-beta Generation in J20 Mice." J. Alzheimers Dis. (2020) 10.3233/jad-191181
[27]
Ramesh M., Govindaraju T.: Lactoferrin: A Potential Theranostic Candidate for Alzheimer's Disease. In: Govindaraju T, ed. Alzheimer's Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities: The Royal Society of Chemistry, 2022; 0.
10.1039/9781839162732-00442
[28]
Yong "Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review" ACS Chem. Neurosci. (2023) 10.1021/acschemneuro.2c00679
[29]
Gao "Brain Iron Metabolism, Redox Balance and Neurological Diseases" Antioxid. (Basel) (2023)
[30]
Junceda "Iron Dysregulation in Alzheimer's Disease: LA-ICP-MS Bioimaging of the Distribution of Iron and Ferroportin in the CA1 Region of the Human Hippocampus" Biomolecules (2024) 10.3390/biom14030295
[31]
Zhou "Iron deposition and distribution across the hippocampus is associated with pattern separation and pattern completion in older adults at risk for Alzheimer's disease" J. Neurosci. (2024) 10.1523/jneurosci.1973-23.2024
[32]
Ishimaru "Deferasirox Targeting Ferroptosis Synergistically Ameliorates Myocardial Ischemia Reperfusion Injury in Conjunction With Cyclosporine A" J. Am. Heart Assoc. (2024) 10.1161/jaha.123.031219
[33]
Xie "Nox4-and Tf/TfR-mediated peroxidation and iron overload exacerbate neuronal ferroptosis after intracerebral hemorrhage: Involvement of EAAT3 dysfunction" Free Radic. Biol. Med (2023) 10.1016/j.freeradbiomed.2023.02.015
[34]
Chen "The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators" Bioorg. Chem. (2023) 10.1016/j.bioorg.2022.106301
[35]
Li "Berberine ameliorates iron levels and ferroptosis in the brain of 3 x Tg-AD mice" Phytomedicine (2023) 10.1016/j.phymed.2023.154962
[36]
Baruah "A natural polyphenol activates and enhances GPX4 to mitigate amyloid-beta induced ferroptosis in Alzheimer's disease." Chem. Sci. (2023) 10.1039/d3sc02350h
[37]
Mohandas "Exploring Lactoferrin as a novel marker for disease pathology and ferroptosis regulation in gestational diabetes" J. Reprod. Immunol. (2024) 10.1016/j.jri.2023.104182
[38]
Zheng "P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability" Free Radic. Biol. Med (2024) 10.1016/j.freeradbiomed.2023.12.047
[39]
Li "USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy" Proc. Natl. Acad. Sci. USA (2024)
[40]
Xiao "Edaravone dexborneol protects against cerebral ischemia/reperfusion-induced blood-brain barrier damage by inhibiting ferroptosis via activation of nrf-2/HO-1/GPX4 signaling" Free Radic. Biol. Med (2024) 10.1016/j.freeradbiomed.2024.03.019
[41]
Zhao "GPX4 degradation contributes to fluoride-induced neuronal ferroptosis and cognitive impairment via mtROS-chaperone-mediated autophagy" Sci. Total Environ. (2024)
[42]
Lee "ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells" Nat. Commun. (2023) 10.1038/s41467-023-44319-3
[43]
Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1
Takahisa Kanekiyo, John R. Cirrito, Chia-Chen Liu et al.
The Journal of Neuroscience
2013
10.1523/jneurosci.3487-13.2013
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Details
- Published
- Nov 01, 2024
- Vol/Issue
- 209
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- 107404
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Cite This Article
Yong-Gang Fan, Ri-Le Ge, Hang Ren, et al. (2024). Astrocyte-derived lactoferrin inhibits neuronal ferroptosis by reducing iron content and GPX4 degradation in APP/PS1 transgenic mice. Pharmacological Research, 209, 107404. https://doi.org/10.1016/j.phrs.2024.107404
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