Lactate-upregulated NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes to ROS-induced osteoarthritis chondrocyte damage

Yi-Fan Huang; Guan Wang; Lu Ding; Zi-Ran Bai; Yi Leng; Jun-Wei Tian; Jian-Zeng Zhang; Yan-Qi Li; Ahmad; Yuan-Hua Qin; Xia Li; Xin Qi

doi:10.1016/j.redox.2023.102867

journal article Open Access Nov 01, 2023

Lactate-upregulated NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes to ROS-induced osteoarthritis chondrocyte damage

Yi-Fan Huang Guan Wang

Lu Ding

Zi-Ran Bai Yi Leng Jun-Wei Tian Jian-Zeng Zhang Yan-Qi Li Ahmad Yuan-Hua Qin Xia Li

Xin Qi

Redox Biology Vol. 67 pp. 102867 · Elsevier BV

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Details

Published: Nov 01, 2023
Vol/Issue: 67
Pages: 102867
License: View

Authors

State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan Provincial Key Lab of Fine Chemistry School of Chemical Engineering and Technology Hainan University Haikou 570228 P. R. China

Sir Run Run Shaw Hospital

X

Xin Qi

Funding

National Natural Science Foundation of China Award: 82071834

Natural Science Foundation of Jilin Province Award: 20200201548JC

Dalian Science and Technology Innovation Fund Award: 2021JJ13SN48

First Hospital of Jilin University

Cite This Article

Yi-Fan Huang, Guan Wang, Lu Ding, et al. (2023). Lactate-upregulated NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes to ROS-induced osteoarthritis chondrocyte damage. Redox Biology, 67, 102867. https://doi.org/10.1016/j.redox.2023.102867

Lactate-upregulated NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes to ROS-induced osteoarthritis chondrocyte damage

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