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References
88
[1]
Ahn "GSK3β, but not GSK3α, inhibits the neuronal differentiation of neural progenitor cells as a downstream target of mammalian target of rapamycin complex1" Stem Cells Dev. (2014) 10.1089/scd.2013.0397
[2]
HTSeq—a Python framework to work with high-throughput sequencing data

Simon Anders, Paul Theodor Pyl, Wolfgang Huber

Bioinformatics 2015 10.1093/bioinformatics/btu638
[3]
Arranz "Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome" Neurobiol. Dis. (2019) 10.1016/j.nbd.2019.02.022
[4]
Balasubramanian "Delineating the phenotypic spectrum of Bainbridge-Ropers syndrome: 12 new patients with de novo, heterozygous, loss-of-function mutations in ASXL3 and review of published literature" J. Med. Genet. (2017) 10.1136/jmedgenet-2016-104360
[5]
Bernier "Disruptive CHD8 mutations define a subtype of autism early in development" Cell (2014) 10.1016/j.cell.2014.06.017
[6]
Birsoy "Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides" Nature (2014) 10.1038/nature13110
[7]
Chenn "Wnt/beta-catenin signaling in cerebral cortical development" Organogenesis (2008) 10.4161/org.4.2.5852
[8]
Cordero "Cranial neural crest cells on the move: their roles in craniofacial development" Am. J. Med. Genet. A. (2011) 10.1002/ajmg.a.33702
[9]
Corley "The roles and regulation of polycomb complexes in neural development" Cell Tissue Res. (2015) 10.1007/s00441-014-2011-9
[10]
Courchesne "Mapping early brain development in autism" Neuron (2007) 10.1016/j.neuron.2007.10.016
[11]
Neuron Number and Size in Prefrontal Cortex of Children With Autism

Eric Courchesne, Peter R. Mouton, Michael E. Calhoun et al.

JAMA 2011 10.1001/jama.2011.1638
[12]
Curtin "Zebrafish wnt9a is expressed in pharyngeal ectoderm and is required for palate and lower jaw development" Mech. Dev. (2011) 10.1016/j.mod.2010.11.003
[13]
De Ferrari "The ups and downs of Wnt signaling in prevalent neurological disorders" Oncogene (2006) 10.1038/sj.onc.1210064
[14]
De Rubeis "Synaptic, transcriptional and chromatin genes disrupted in autism" Nature (2014) 10.1038/nature13772
[15]
Deguchi "Reelin and disabled-1 expression in developing and mature human cortical neurons" J. Neuropathol. Exp. Neurol. (2003) 10.1093/jnen/62.6.676
[16]
Dorsky "Control of neural crest cell fate by the Wnt signalling pathway" Nature (1998) 10.1038/24620
[17]
Dougherty "Distinct requirements for wnt9a and irf6 in extension and integration mechanisms during zebrafish palate morphogenesis" Development (2013) 10.1242/dev.080473
[18]
Durak "Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling" Nat. Neurosci. (2016) 10.1038/nn.4400
[19]
Durand "Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders" Nat. Genet. (2007) 10.1038/ng1933
[20]
Earl "Clinical phenotype of ASD-associated DYRK1A haploinsufficiency" Mol. Autism (2017) 10.1186/s13229-017-0173-5
[21]
Ernst "Proliferation and differentiation deficits are a major convergence point for neurodevelopmental disorders" Trends Neurosci. (2016) 10.1016/j.tins.2016.03.001
[22]
Fattahi "Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease" Nature (2016) 10.1038/nature16951
[23]
Histone Lysine Methylases and Demethylases in the Landscape of Human Developmental Disorders

Víctor Faundes, William G. Newman, Laura Bernardini et al.

The American Journal of Human Genetics 2018 10.1016/j.ajhg.2017.11.013
[24]
Fukuchi-Shimogori "Neocortex patterning by the secreted signaling molecule FGF8" Science (2001) 10.1126/science.1064252
[25]
Gallagher "Ankrd11 is a chromatin regulator involved in autism that is essential for neural development" Dev. Cell (2015) 10.1016/j.devcel.2014.11.031
[26]
Gilman "Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses" Neuron (2011) 10.1016/j.neuron.2011.05.021
[27]
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

Joseph T. Glessner, KAI WANG, Guiqing Cai et al.

Nature 2009 10.1038/nature07953
[28]
Gompers "Germline Chd8 haploinsufficiency alters brain development in mouse" Nat. Neurosci. (2017) 10.1038/nn.4592
[29]
Gregory "Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes" Mol. Cell. Biol. (2007) 10.1128/mcb.00993-07
[30]
Hahm "Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1" Mol. Cell. Biol. (2004) 10.1128/mcb.24.5.2074-2082.2004
[31]
Hammond "Cortical layer development and orientation is modulated by relative contributions of reelin-negative and -positive neurons in mouse chimeras" Cereb. Cortex (2010) 10.1093/cercor/bhp287
[32]
Hawrylycz "An anatomically comprehensive atlas of the adult human brain transcriptome" Nature (2012) 10.1038/nature11405
[33]
Hazlett "Early brain development in infants at high risk for autism spectrum disorder" Nature (2017) 10.1038/nature21369
[34]
Hernández-Muñoz "Stable X chromosome inactivation involves the PRC1 polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase" Proc. Natl. Acad. Sci. U S A (2005) 10.1073/pnas.0408918102
[35]
Absolute quantification by droplet digital PCR versus analog real-time PCR

Christopher M Hindson, John R Chevillet, Hilary A Briggs et al.

Nature Methods 2013 10.1038/nmeth.2633
[36]
Hirabayashi "The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells" Development (2004) 10.1242/dev.01165
[37]
Hirabayashi "Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition" Neuron (2009) 10.1016/j.neuron.2009.08.021
[38]
Huang "The epigenetic factor Kmt2a/Mll1 regulates neural progenitor proliferation and neuronal and glial differentiation" Dev. Neurobiol. (2015) 10.1002/dneu.22235
[39]
The contribution of de novo coding mutations to autism spectrum disorder

Ivan Iossifov, Brian J. O’Roak, Stephan J. Sanders et al.

Nature 2014 10.1038/nature13908
[40]
Iossifov "Low load for disruptive mutations in autism genes and their biased transmission" Proc. Natl. Acad. Sci. U S A (2015) 10.1073/pnas.1516376112
[41]
Jamain "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism" Nat. Genet. (2003) 10.1038/ng1136
[42]
Johnson "Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex" Nat. Neurosci. (2015) 10.1038/nn.3980
[43]
Jung "Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior" Nat. Neurosci. (2017) 10.1038/s41593-017-0013-0
[44]
Kalkman "A review of the evidence for the canonical Wnt pathway in autism spectrum disorders" Mol. Autism (2012) 10.1186/2040-2392-3-10
[45]
Kamel "Requirement for frzb and fzd7a in cranial neural crest convergence and extension mechanisms during zebrafish palate and jaw morphogenesis" Dev. Biol. (2013) 10.1016/j.ydbio.2013.06.012
[46]
Kim "GSK-3 is a master regulator of neural progenitor homeostasis" Nat. Neurosci. (2009) 10.1038/nn.2408
[47]
Kim "Chd2 is necessary for neural circuit development and long-term memory" Neuron (2018) 10.1016/j.neuron.2018.09.049
[48]
Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder

Tom S. Koemans, Tjitske Kleefstra, Melissa C. Chubak et al.

PLOS Genetics 2017 10.1371/journal.pgen.1006864
[49]
Komada "Hedgehog signaling is involved in development of the neocortex" Development (2008) 10.1242/dev.015891
[50]
Krumm "A de novo convergence of autism genetics and molecular neuroscience" Trends Neurosci. (2014) 10.1016/j.tins.2013.11.005

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References
Details
Published
Jul 01, 2020
Vol/Issue
27(1)
Pages
35-49.e6
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Funding
National Cancer Institute
National Institutes of Health Award: F30 MH113343-01A1
National Institute of General Medical Sciences Award: DP2CA186572
Memorial Sloan-Kettering Cancer Center
Israel National Road Safety Authority
Melanoma Research Alliance Award: N13S-011
New York State Stem Cell Science
Pershing Square Foundation
Cite This Article
Gustav Y. Cederquist, Jason Tchieu, Scott J. Callahan, et al. (2020). A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes. Cell Stem Cell, 27(1), 35-49.e6. https://doi.org/10.1016/j.stem.2020.06.004
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