Micro- and nanoplastic toxicity in humans: Exposure pathways, cellular effects, and mitigation strategies

Faezeh Jahedi; Neamatollah Jaafarzadeh Haghighi Fard

doi:10.1016/j.toxrep.2025.102043

journal article Open Access Jun 01, 2025

Micro- and nanoplastic toxicity in humans: Exposure pathways, cellular effects, and mitigation strategies

Faezeh Jahedi

Neamatollah Jaafarzadeh Haghighi Fard

Toxicology Reports Vol. 14 pp. 102043 · Elsevier BV

View at Publisher Save 10.1016/j.toxrep.2025.102043

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References

141

[1]

Future scenarios of global plastic waste generation and disposal

Laurent Lebreton, Anthony Andrady

Palgrave Communications 2019 10.1057/s41599-018-0212-7

[2]

Real, L.E.P., Plastics statistics: production, recycling, and market data, in Recycled Materials for Construction Applications: Plastic Products and Composites. 2022, Springer. p. 103-113. 10.1007/978-3-031-14872-9_5

[3]

Dris "A first overview of textile fibers, including microplastics, in indoor and outdoor environments" Environ. Pollut. (2017) 10.1016/j.envpol.2016.12.013

[4]

Napper "Characterisation, quantity and sorptive properties of microplastics extracted from cosmetics" Mar. Pollut. Bull. (2015) 10.1016/j.marpolbul.2015.07.029

[5]

Li "Effects of nanoplastics on energy metabolism in the oriental river prawn (Macrobrachium nipponense)" Environ. Pollut. (2021) 10.1016/j.envpol.2020.115890

[6]

Jahedi "Spatial mapping and risk assessment of microplastic contamination in drinking water catchments from north of the Persian Gulf" Environ. Monit. Assess. (2025) 10.1007/s10661-025-13859-0

[7]

Jaafarzadeh Haghighi Fard "The Possibility of Microplastic Removal by Earthworms and Comparing With Conventional Chemical Removal Methods (A Global and Deeply Systematic Review)" J. Polym. Environ. (2023) 10.1007/s10924-023-02954-3

[8]

Jahedi "A Systematic Review of Biomonitoring Microplastics in Environmental Matrices: Emphasis on Airborne Particles, Dry Deposits, and Comparative Analysis with Traditional Methods" Environ. Adv. (2025) 10.1016/j.envadv.2025.100609

[9]

Mason "Plastics, plastics everywhere" Am. Sci. (2019) 10.1511/2019.107.5.284

[10]

Chain "C.i.t.F., Presence of microplastics and nanoplastics in food, with particular focus on seafood" Efsa J. (2016)

[11]

Gallo "Marine litter plastics and microplastics and their toxic chemicals components: the need for urgent preventive measures" Environ. Sci. Eur. (2018) 10.1186/s12302-018-0139-z

[12]

GESAMP "Sources, fate and effects of microplastics in the marine environment: part two of a global assessment" IMO Lond. (2016)

[13]

Karbalaei "Occurrence, sources, human health impacts and mitigation of microplastic pollution" Environ. Sci. Pollut. Res. (2018) 10.1007/s11356-018-3508-7

[14]

Detection of microplastics in human colectomy specimens

Yusof Shuaib Ibrahim, Sabiqah Tuan Anuar, Alyza A Azmi et al.

JGH Open 2021 10.1002/jgh3.12457

[15]

Jaafarzadeh Haghighi Fard "Microplastics as vectors for antibiotic resistance genes and their implications for gut health" Discov. Med. (2025) 10.1007/s44337-025-00195-y

[16]

Plasticenta: First evidence of microplastics in human placenta

Antonio Ragusa, Alessandro Svelato, Criselda Santacroce et al.

Environment International 2021 10.1016/j.envint.2020.106274

[17]

Presence of airborne microplastics in human lung tissue

Luís Fernando Amato-Lourenço, Regiani Carvalho-Oliveira, Gabriel Ribeiro Júnior et al.

Journal of Hazardous Materials 2021 10.1016/j.jhazmat.2021.126124

[18]

Pauly "Inhaled cellulosic and plastic fibers found in human lung tissue. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research" cosponsored Am. Soc. Prev. Oncol. (1998)

[19]

Fard "Systematic review of pulmonary toxicity induced by microplastics and nanoplastics: Insights from in vivo and in vitro studies" Toxicol. Anal. Et. Clin. (2025)

[20]

Jahedi "Microplastics in urine, sputum and lung lavage fluid from patients with respiratory illnesses" Environ. Res. (2025) 10.1016/j.envres.2025.121278

[21]

Detection of Various Microplastics in Human Stool

Philipp Schwabl, Sebastian Köppel, Philipp Königshofer et al.

Annals of Internal Medicine 2019 10.7326/m19-0618

[22]

van Emmerik "Plastic debris in rivers" Wiley Interdiscip. Rev.: Water (2020)

[23]

Interactions of microplastic debris throughout the marine ecosystem

Tamara S. Galloway, Matthew Cole, Ceri Lewis

Nature Ecology & Evolution 2017 10.1038/s41559-017-0116

[24]

Microplastic particles cause intestinal damage and other adverse effects in zebrafish Danio rerio and nematode Caenorhabditis elegans

Lili Lei, Siyu Wu, Shibo Lu et al.

Science of The Total Environment 2018 10.1016/j.scitotenv.2017.11.103

[25]

Mathalon "Microplastic fibers in the intertidal ecosystem surrounding Halifax Harbor, Nova Scotia" Mar. Pollut. Bull. (2014) 10.1016/j.marpolbul.2014.02.018

[26]

Naji "Microplastics contamination in molluscs from the northern part of the Persian Gulf" Environ. Pollut. (2018) 10.1016/j.envpol.2017.12.046

[27]

Bessa "Occurrence of microplastics in commercial fish from a natural estuarine environment" Mar. Pollut. Bull. (2018) 10.1016/j.marpolbul.2018.01.044

[28]

Neves "Ingestion of microplastics by commercial fish off the Portuguese coast" Mar. Pollut. Bull. (2015) 10.1016/j.marpolbul.2015.11.008

[29]

Liebezeit "Non-pollen particulates in honey and sugar" Food Addit. Contam. Part A (2013) 10.1080/19440049.2013.843025

[30]

Karami "The presence of microplastics in commercial salts from different countries" Sci. Rep. (2017) 10.1038/srep46173

[31]

Alma "Microplastics incorporated by honeybees from food are transferred to honey, wax and larvae" Environ. Pollut. (2023) 10.1016/j.envpol.2023.121078

[32]

Fard "Microplastics and nanoplastics in tea: sources, characteristics and potential impacts" Food Chem. (2024)

[33]

Oßmann "Small-sized microplastics and pigmented particles in bottled mineral water" Water Res. (2018) 10.1016/j.watres.2018.05.027

[34]

Dris "Microplastic contamination in an urban area: a case study in Greater Paris" Environ. Chem. (2015) 10.1071/en14167

[35]

Airborne microplastics: Consequences to human health?

Joana Correia Prata

Environmental Pollution 2018 10.1016/j.envpol.2017.11.043

[36]

Dris "Synthetic fibers in atmospheric fallout: a source of microplastics in the environment?" Mar. Pollut. Bull. (2016) 10.1016/j.marpolbul.2016.01.006

[37]

Detection of microplastics in human lung tissue using μFTIR spectroscopy

Lauren C. Jenner, Jeanette M. Rotchell, Robert T. Bennett et al.

Science of The Total Environment 2022 10.1016/j.scitotenv.2022.154907

[38]

Detection and Analysis of Microplastics in Human Sputum

Shirley Chien-Chieh Huang, Xiaoshuang Huang, Ran Bi et al.

Environmental Science & Technology 2022 10.1021/acs.est.1c03859

[39]

Post COVID-19 pandemic: Biofragmentation and soil ecotoxicological effects of microplastics derived from face masks

Jin Il Kwak, Youn-Joo An

Journal of Hazardous Materials 2021 10.1016/j.jhazmat.2021.126169

[40]

Microplastics in the aquatic and terrestrial environment: sources (with a specific focus on personal care products), fate and effects

Karen Duis, Anja Coors

Environmental Sciences Europe 2016 10.1186/s12302-015-0069-y

[41]

Microplastic pollution, a threat to marine ecosystem and human health: a short review

Shivika Sharma, Subhankar Chatterjee

Environmental Science and Pollution Research 2017 10.1007/s11356-017-9910-8

[42]

Cytotoxic effects of commonly used nanomaterials and microplastics on cerebral and epithelial human cells

Gabriella F. Schirinzi, Ignacio Pérez-Pomeda, Josep Sanchís et al.

Environmental Research 2017 10.1016/j.envres.2017.08.043

[43]

Dissemination of Wear Particles to the Liver, Spleen, and Abdominal Lymph Nodes of Patients with Hip or Knee Replacement*

ROBERT M. URBAN, JOSHUA J. JACOBS, MICHAEL J. TOMLINSON et al.

The Journal of Bone & Joint Surgery 2000 10.2106/00004623-200004000-00002

[44]

Suñer "Ultrahigh molecular weight polyethylene/graphene oxide nanocomposites: Wear characterization and biological response to wear particles" J. Biomed. Mater. Res. Part B Appl. Biomater. (2018) 10.1002/jbm.b.33821

[45]

Massin "How does total knee replacement technique influence polyethylene wear?" Orthop. Trauma. Surg. Res (2017)

[46]

Massin "Wear products of total hip arthroplasty: the case of polyethylene" Morphologie (2017) 10.1016/j.morpho.2016.06.001

[47]

Discovery and quantification of plastic particle pollution in human blood

Heather A. Leslie, Martin J.M. van Velzen, Sicco H. Brandsma et al.

Environment International 2022 10.1016/j.envint.2022.107199

[48]

Discovery and quantification of plastic particle pollution in human blood

Heather A. Leslie, Martin J.M. van Velzen, Sicco H. Brandsma et al.

Environment International 2022 10.1016/j.envint.2022.107199

[49]

Guan "The landscape of micron-scale particles including microplastics in human enclosed body fluids" J. Hazard. Mater. (2023) 10.1016/j.jhazmat.2022.130138

[50]

Chen "An emerging role of microplastics in the etiology of lung ground glass nodules" Environ. Sci. Eur. (2022) 10.1186/s12302-022-00605-3

Showing 50 of 141 references

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Metrics

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Citations

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Details

Published: Jun 01, 2025
Vol/Issue: 14
Pages: 102043
License: View

Authors

F

Faezeh Jahedi

N

Neamatollah Jaafarzadeh Haghighi Fard

Cite This Article

Faezeh Jahedi, Neamatollah Jaafarzadeh Haghighi Fard (2025). Micro- and nanoplastic toxicity in humans: Exposure pathways, cellular effects, and mitigation strategies. Toxicology Reports, 14, 102043. https://doi.org/10.1016/j.toxrep.2025.102043

Micro- and nanoplastic toxicity in humans: Exposure pathways, cellular effects, and mitigation strategies

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