The comprehensive oral microbiome landscape unveils its interplay with poor oral health in esophageal squamous cell carcinoma risk

Peipei Gao; Huangbo Yuan; Zhendong Mei; Xiaolin Yin; Yixin Zeng; Zhenqiu Liu; Xiaorong Yang; Jiangli Xue; Zidong Liu; Yanfeng Jiang; Weimin Ye; Ming Lu; Chen Suo

doi:10.1016/j.xcrm.2025.102431

journal article Open Access Nov 01, 2025

The comprehensive oral microbiome landscape unveils its interplay with poor oral health in esophageal squamous cell carcinoma risk

Peipei Gao

Huangbo Yuan Zhendong Mei Xiaolin Yin Yixin Zeng Zhenqiu Liu

Xiaorong Yang

Jiangli Xue Zidong Liu Yanfeng Jiang Weimin Ye

Ming Lu

Chen Suo

Cell Reports Medicine Vol. 6 No. 11 pp. 102431 · Elsevier BV

View at Publisher Save 10.1016/j.xcrm.2025.102431

Topics

No keywords indexed for this article. Browse by subject →

References

94

[1]

Watt "Ending the neglect of global oral health: time for radical action" Lancet (London, England) (2019) 10.1016/s0140-6736(19)31133-x

[2]

Lee "Oral health and gastrointestinal cancer: A nationwide cohort study" J. Clin. Periodontol. (2020) 10.1111/jcpe.13304

[3]

Zhang "Poor oral health and risks of total and site-specific cancers in China: A prospective cohort study of 0.5 million adults" eClinicalMedicine (2022) 10.1016/j.eclinm.2022.101330

[4]

Mmbaga "Missing and decayed teeth, oral hygiene and dental staining in relation to esophageal cancer risk: ESCCAPE case-control study in Kilimanjaro, Tanzania" Int. J. Cancer (2021) 10.1002/ijc.33433

[5]

Bray "Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries" CA Cancer J. Clin. (2024)

[6]

Narikiyo "Frequent and preferential infection of Treponema denticola, Streptococcus mitis, and Streptococcus anginosus in esophageal cancers" Cancer Sci. (2004) 10.1111/j.1349-7006.2004.tb02488.x

[7]

Chen "Poor oral health is associated with an increased risk of esophageal squamous cell carcinoma - a population-based case-control study in China" Int. J. Cancer (2017) 10.1002/ijc.30484

[8]

The oral microbiome: diversity, biogeography and human health

Jonathon L. Baker, Jessica L. Mark Welch, Kathryn M. Kauffman et al.

Nature Reviews Microbiology 2024 10.1038/s41579-023-00963-6

[9]

Szafrański "The human oral phageome" Periodontol 2000 (2021) 10.1111/prd.12363

[10]

Baker "Ecology of the Oral Microbiome: Beyond Bacteria" Trends Microbiol. (2017) 10.1016/j.tim.2016.12.012

[11]

Li "Association between oral microflora and gastrointestinal tumors" Oncol. Rep. (2021) 10.3892/or.2021.8111

[12]

Wang "Oral Microbiota: A New Insight into Cancer Progression, Diagnosis and Treatment" Phenomics (2023) 10.1007/s43657-023-00124-y

[13]

Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers

Jing Wu, Zhiheng Pei, Liying Yang et al.

Cancer Research 2017 10.1158/0008-5472.can-17-1296

[14]

Chen "Porphyromonas gingivalis promotes tumor progression in esophageal squamous cell carcinoma" Cell. Oncol. (2021) 10.1007/s13402-020-00573-x

[15]

PICRUSt2 for prediction of metagenome functions

Gavin M. Douglas, Vincent J. Maffei, Jesse R. Zaneveld et al.

Nature Biotechnology 2020 10.1038/s41587-020-0548-6

[16]

Illuminating the oral microbiome and its host interactions: recent advancements in omics and bioinformatics technologies in the context of oral microbiome research

Jonathon L Baker

FEMS Microbiology Reviews 2023 10.1093/femsre/fuad051

[17]

Zhang "Poor oral hygiene behavior is associated with an increased risk of gastric cancer: A population-based case-control study in China" J. Periodontol. (2022) 10.1002/jper.21-0301

[18]

Chen "Non-invasive early detection of cancer four years before conventional diagnosis using a blood test" Nat. Commun. (2020) 10.1038/s41467-020-17316-z

[19]

Wang "Rationales, design and recruitment of the Taizhou Longitudinal Study" BMC Public Health (2009) 10.1186/1471-2458-9-223

[20]

Keijser "Pyrosequencing analysis of the oral microflora of healthy adults" J. Dent. Res. (2008) 10.1177/154405910808701104

[21]

Preza "Bacterial profiles of root caries in elderly patients" J. Clin. Microbiol. (2008) 10.1128/jcm.02411-07

[22]

Liu "Multi-kingdom microbiota analyses identify bacterial-fungal interactions and biomarkers of colorectal cancer across cohorts" Nat. Microbiol. (2022) 10.1038/s41564-021-01030-7

[23]

Chen "Predictive value of the presence of Prevotella and the ratio of Porphyromonas gingivalis to Prevotella in saliva for esophageal squamous cell carcinoma" Front. Cell. Infect. Microbiol. (2022) 10.3389/fcimb.2022.997333

[24]

He "Oral microbiota disorder in GC patients revealed by 2b-RAD-M" J. Transl. Med. (2023) 10.1186/s12967-023-04599-1

[25]

Chen "Characteristics of the oral and gastric microbiome in patients with early-stage intramucosal esophageal squamous cell carcinoma" BMC Microbiol. (2024) 10.1186/s12866-024-03233-4

[26]

Takeshita "Bacterial diversity in saliva and oral health-related conditions: the Hisayama Study" Sci. Rep. (2016) 10.1038/srep22164

[27]

Eren "Oligotyping analysis of the human oral microbiome" Proc. Natl. Acad. Sci. USA (2014) 10.1073/pnas.1409644111

[28]

Galvin "Smoking, tooth loss and oral hygiene practices have significant and site-specific impacts on the microbiome of oral mucosal surfaces: a cross-sectional study" J. Oral Microbiol. (2023) 10.1080/20002297.2023.2263971

[29]

Chen "Oral Microbiota and Risk for Esophageal Squamous Cell Carcinoma in a High-Risk Area of China" PLoS One (2015)

[30]

de Lillo "Culture-independent identification of periodontitis-associated Porphyromonas and Tannerella populations by targeted molecular analysis" J. Clin. Microbiol. (2004) 10.1128/jcm.42.12.5523-5527.2004

[31]

Abdulkareem "Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis" J. Oral Microbiol. (2023) 10.1080/20002297.2023.2197779

[32]

Saliva microbiomes distinguish caries-active from healthy human populations

Fang Yang, Xiaowei Zeng, Kang Ning et al.

The ISME Journal 2012 10.1038/ismej.2011.71

[33]

Teng "Prediction of Early Childhood Caries via Spatial-Temporal Variations of Oral Microbiota" Cell Host Microbe (2015) 10.1016/j.chom.2015.08.005

[34]

Lee "Cycling back to folate metabolism in cancer" Nat. Cancer (2024) 10.1038/s43018-024-00739-8

[35]

Methionine metabolism in health and cancer: a nexus of diet and precision medicine

Sydney M. Sanderson, Xia Gao, Ziwei Dai et al.

Nature Reviews Cancer 2019 10.1038/s41568-019-0187-8

[36]

Fini "Contribution of uric acid to cancer risk, recurrence, and mortality" Clin. Transl. Med. (2012) 10.1186/2001-1326-1-16

[37]

Keshet "Rewiring urea cycle metabolism in cancer to support anabolism" Nat. Rev. Cancer (2018) 10.1038/s41568-018-0054-z

[38]

Ghosh "Reprogramming of urea cycle in cancer: Mechanism, regulation and prospective therapeutic scopes" Biochem. Pharmacol. (2024) 10.1016/j.bcp.2024.116326

[39]

Gao "Association between serum urea concentrations and the risk of colorectal cancer, particularly in individuals with type 2 diabetes: A cohort study" Int. J. Cancer (2024) 10.1002/ijc.34719

[40]

Liu "Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries" Int. J. Oral Sci. (2012) 10.1038/ijos.2012.54

[41]

Hallmarks of Cancer: The Next Generation

Douglas Hanahan, Robert A. Weinberg

Cell 2011 10.1016/j.cell.2011.02.013

[42]

Patra "Supra-physiological concentration of glyoxylate inhibits proliferation of human colon cancer cells through oxidative stress" Life Sci. (2018) 10.1016/j.lfs.2018.05.047

[43]

van den Broek "Highly Selective and Rapid Breath Isoprene Sensing Enabled by Activated Alumina Filter" ACS Sens. (2018) 10.1021/acssensors.7b00976

[44]

Bird "Future directions--toxicology studies of 1,3-butadiene and isoprene" Environ. Health Perspect. (1990)

[45]

Smyth "Oesophageal cancer" Nat. Rev. Dis. Primers (2017) 10.1038/nrdp.2017.48

[46]

Wang "Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy" Mol. Cell (2020) 10.1016/j.molcel.2020.09.006

[47]

Chen "Arginine Signaling and Cancer Metabolism" Cancers (2021)

[48]

Busch "Interdependence of tetrapyrrole metabolism, the generation of oxidative stress and the mitigative oxidative stress response" Redox Biol. (2015) 10.1016/j.redox.2015.01.010

[49]

Wang "Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial-mesenchymal transition" Stem Cell Res. Ther. (2019) 10.1186/s13287-019-1265-2

[50]

Role of the Microbiota in Immunity and Inflammation

Yasmine Belkaid, Timothy W. Hand

Cell 2014 10.1016/j.cell.2014.03.011

Showing 50 of 94 references

Metrics

2

Citations

94

References

Details

Published: Nov 01, 2025
Vol/Issue: 6(11)
Pages: 102431
License: View

Authors

Institute of Plant Protection, Sichuan Academy of Agricultural Sciences/Key Laboratory of Integrated Crop Pest Management in Southwest China, Ministry of Agriculture, Chengdu 610066, China

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;; School of Public Health, Fujian Medical University, Fuzhou, China.

Department of Epidemiology & Ministry of Education Key Laboratory of Public Health Safety School of Public Health Fudan University Shanghai China; Fudan University Taizhou Institute of Health Sciences Taizhou China

Funding

National Natural Science Foundation of China Award: 82473700

National Key Research and Development Program of China Award: 2023YFC2508001

Science and Technology Commission of Shanghai Municipality Award: ZD2021CY001

Cite This Article

Peipei Gao, Huangbo Yuan, Zhendong Mei, et al. (2025). The comprehensive oral microbiome landscape unveils its interplay with poor oral health in esophageal squamous cell carcinoma risk. Cell Reports Medicine, 6(11), 102431. https://doi.org/10.1016/j.xcrm.2025.102431

The comprehensive oral microbiome landscape unveils its interplay with poor oral health in esophageal squamous cell carcinoma risk

You May Also Like