Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study

Jeffrey J Bazarian; Peter Biberthaler; Robert D Welch; Lawrence M Lewis; Pál Barzó; Viktoria Bogner-Flatz; P Gunnar Brolinson; András Büki; James Y Chen; Robert H Christenson; Dallas Hack; J Stephen Huff; Sandeep Johar; J Dedrick Jordan; Bernd A Leidel; Tobias Lindner; Elizabeth Ludington; David O Okonkwo; Joseph Ornato; W Frank Peacock; Kara Schmidt; Joseph A Tyndall; Arastoo Vossough; Andy S Jagoda

doi:10.1016/s1474-4422(18)30231-x

journal article Open Access Sep 01, 2018

Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study

Jeffrey J Bazarian Peter Biberthaler Robert D Welch Lawrence M Lewis Pál Barzó Viktoria Bogner-Flatz P Gunnar Brolinson András Büki James Y Chen Robert H Christenson Dallas Hack J Stephen Huff Sandeep Johar J Dedrick Jordan Bernd A Leidel Tobias Lindner Elizabeth Ludington David O Okonkwo Joseph Ornato W Frank Peacock Kara Schmidt Joseph A Tyndall Arastoo Vossough Andy S Jagoda

The Lancet Neurology Vol. 17 No. 9 pp. 782-789 · Elsevier BV

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References

27

[1]

Feigin "Incidence of traumatic brain injury in New Zealand: a population-based study" Lancet Neurol (2013) 10.1016/s1474-4422(12)70262-4

[2]

Marin "Trends in visits for traumatic brain injury to emergency departments in the United States" JAMA (2014) 10.1001/jama.2014.3979

[3]

Jagoda "Clinical policy: neuroimaging and decisionmaking in adult mild traumatic brain injury in the acute setting" Ann Emerg Med (2008) 10.1016/j.annemergmed.2008.08.021

[4]

Computed Tomography — An Increasing Source of Radiation Exposure

David J. Brenner, Eric J. Hall

New England Journal of Medicine 2007 10.1056/nejmra072149

[5]

Sharp "Computed tomography use for adults with head injury: describing likely avoidable emergency department imaging based on the Canadian CT head rule" Acad Emerg Med (2017) 10.1111/acem.13061

[6]

Easter "Will neuroimaging reveal a severe intracranial injury in this adult with minor head trauma?: the rational clinical examination systematic review" JAMA (2015) 10.1001/jama.2015.16316

[7]

Melnick "CT overuse for mild traumatic brain injury" Jt Comm J Qual Patient Saf (2012)

[8]

Welch "Ability of serum glial fibrillary acidic protein, ubiquitin C-terminal hydrolase-L1, and S100B to differentiate normal and abnormal head computed tomography findings in patients with suspected mild or moderate traumatic brain injury" J Neurotrauma (2016) 10.1089/neu.2015.4149

[9]

Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury

Linda Papa, Gretchen M. Brophy, Robert D. Welch et al.

JAMA Neurology 2016 10.1001/jamaneurol.2016.0039

[10]

Diaz-Arrastia "Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein" J Neurotrauma (2014) 10.1089/neu.2013.3040

[11]

Unden "Can low serum levels of S100B predict normal CT findings after minor head injury in adults?: an evidence-based review and meta-analysis" J Head Trauma Rehabil (2010) 10.1097/htr.0b013e3181e57e22

[12]

Unden "Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults: an evidence and consensus-based update" BMC Med (2013) 10.1186/1741-7015-11-50

[13]

Tosetti "Toward an international initiative for traumatic brain injury research" J Neurotrauma (2013) 10.1089/neu.2013.2896

[14]

Ottens "Novel neuroproteomic approaches to studying traumatic brain injury" Prog Brain Res (2007) 10.1016/s0079-6123(06)61029-7

[15]

Papa "Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention" J Trauma Acute Care Surg (2012) 10.1097/ta.0b013e3182491e3d

[16]

Papa "GFAP out-performs S100beta in detecting traumatic intracranial lesions on computed tomography in trauma patients with mild traumatic brain injury and those with extracranial lesions" J Neurotrauma (2014) 10.1089/neu.2013.3245

[17]

Roozenbeek "Changing patterns in the epidemiology of traumatic brain injury" Nat Rev Neurol (2013) 10.1038/nrneurol.2013.22

[18]

Bullock "Surgical management of acute epidural hematomas, acute subdural hematomas, and traumatic parenchymal lesions" Neurosurgery (2006)

[19]

Stein "A critical comparison of clinical decision instruments for computed tomographic scanning in mild closed traumatic brain injury in adolescents and adults" Ann Emerg Med (2009) 10.1016/j.annemergmed.2008.01.002

[20]

Stiell "A prospective cluster-randomized trial to implement the Canadian CT Head Rule in emergency departments" CMAJ (2010) 10.1503/cmaj.091974

[21]

Tavender "Understanding practice: the factors that influence management of mild traumatic brain injury in the emergency department—a qualitative study using the Theoretical Domains Framework" Implement Sci (2014) 10.1186/1748-5908-9-8

[22]

Heidari "S100B protein as a screening tool for computed tomography findings after mild traumatic brain injury: systematic review and meta-analysis" Brain Inj (2015) 10.3109/02699052.2015.1037349

[23]

Barbosa "Evaluation and management of mild traumatic brain injury: an Eastern Association for the Surgery of Trauma practice management guideline" J Trauma Acute Care Surg (2012) 10.1097/ta.0b013e3182701885

[24]

Kou "Combining biochemical and imaging markers to improve diagnosis and characterization of mild traumatic brain injury in the acute setting: results from a pilot study" PLoS One (2013) 10.1371/journal.pone.0080296

[25]

Siman "Evidence that the blood biomarker SNTF predicts brain imaging changes and persistent cognitive dysfunction in mild TBI patients" Front Neurol (2013) 10.3389/fneur.2013.00190

[26]

Stiell "Methodologic standards for the development of clinical decision rules in emergency medicine" Ann Emerg Med (1999) 10.1016/s0196-0644(99)70309-4

[27]

Huff "Differences in interpretation of cranial computed tomography in ED traumatic brain injury patients by expert neuroradiologists" Am J Emerg Med (2014) 10.1016/j.ajem.2014.03.010

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Metrics

508

Citations

27

References

Details

Published: Sep 01, 2018
Vol/Issue: 17(9)
Pages: 782-789
License: View

Authors

Viktoria Bogner-Flatz

Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania

A

Andy S Jagoda

Funding

BrainScope Company

Cite This Article

Jeffrey J Bazarian, Peter Biberthaler, Robert D Welch, et al. (2018). Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study. The Lancet Neurology, 17(9), 782-789. https://doi.org/10.1016/s1474-4422(18)30231-x

Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study

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