Integrated, Nontargeted Ultrahigh Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Platform for the Identification and Relative Quantification of the Small-Molecule Complement of Biological Systems

Anne M. Evans; Corey D. DeHaven; Tom Barrett; Matt Mitchell; Eric Milgram

doi:10.1021/ac901536h

journal article Jul 22, 2009

Integrated, Nontargeted Ultrahigh Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Platform for the Identification and Relative Quantification of the Small-Molecule Complement of Biological Systems

Anne M. Evans Corey D. DeHaven Tom Barrett Matt Mitchell Eric Milgram

Analytical Chemistry Vol. 81 No. 16 pp. 6656-6667 · American Chemical Society (ACS)

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References

50

[1]

Dunn W. Phys. Biol. (2008) 10.1088/1478-3975/5/1/011001

[2]

Lu W. J. Chromatogr., B (2008) 10.1016/j.jchromb.2008.04.031

[3]

Sabatine M. S. Circulation (2005) 10.1161/circulationaha.105.569137

[4]

Sawada Y. Plant Cell Physiol. (2009) 10.1093/pcp/pcn183

[5]

Goodacre R. Trends Biotechnol. (2004) 10.1016/j.tibtech.2004.03.007

[6]

Fiehn O. Plant Mol. Biol. (2002) 10.1023/a:1013713905833

[7]

Werner E. J. Chromatogr., B (2008) 10.1016/j.jchromb.2008.07.004

[8]

Nordstrom A. Anal. Chem. (2008) 10.1021/ac701982e

[9]

Patterson A. D. Anal. Chem. (2008) 10.1021/ac701807v

[10]

Wilson I. D. J. Proteome Res. (2005) 10.1021/pr049769r

[11]

Want E. J. Proteome Res. (2007) 10.1021/pr060505+

[12]

Wilson I. D. J. Chromatogr., B (2005) 10.1016/j.jchromb.2004.07.045

[13]

Timischl B. Electrophoresis (2008) 10.1002/elps.200700517

[14]

Schauer N. FEBS Lett. (2005) 10.1016/j.febslet.2005.01.029

[15]

Issaq H. J. J. Sep. Sci. (2008) 10.1002/jssc.200700601

[16]

Want E. ChemBioChem (2005) 10.1002/cbic.200500151

[17]

Brindle J. T. Nat. Med. (2002) 10.1038/nm1202-802

[18]

Clayton T. A. Nature (2006) 10.1038/nature04648

[19]

Griffin J. L. Nat. Rev. (2004) 10.1038/nrc1390

[20]

Holmes E. PLoS Med. (2006)

[21]

Tolstikov V. Anal. Biochem. (2002) 10.1006/abio.2001.5513

[22]

Van der Werf M. J. Anal. Biochem. (2007) 10.1016/j.ab.2007.07.022

[23]

Nordstrom A. Anal. Chem. (2006) 10.1021/ac060245f

[24]

Plumb R. Rapid Commun. Mass Spectrom. (2004) 10.1002/rcm.1627

[25]

Kitteringham N. R. J. Chromatogr., B (2009) 10.1016/j.jchromb.2008.11.013

[26]

Woo H. M. Clin. Chim. Acta (2009) 10.1016/j.cca.2008.10.014

[27]

Katajamaa M. J. Chromatogr., A (2007) 10.1016/j.chroma.2007.04.021

[28]

Broadhurst D. I. Metabolomics (2006) 10.1007/s11306-006-0037-z

[29]

Chen J. Anal. Chem. (2008) 10.1021/ac702089h

[30]

Kind T. BMC Bioinf. (2007) 10.1186/1471-2105-8-105

[31]

Kind T. BMC Bioinf. (2006) 10.1186/1471-2105-7-234

[32]

Gugisch R. MATCH (2007)

[33]

Sangster T. Analyst (2006) 10.1039/b604498k

[34]

Dyson N. (1990)

[35]

Halket J. M. J. Exp. Bot. (2005) 10.1093/jxb/eri069

[36]

Kovats E. Helv. Chim. Acta (1958) 10.1002/hlca.19580410703

[37]

(1997)

[38]

Young, S., Barrett, T. and Beecher, C.(Metabolon). U.S. Patent 7,561,975, 2007.

[39]

Want E. J. Anal. Chem. (2006) 10.1021/ac051312t

[40]

t’Kindt R. J. Chromatogr., B (2008) 10.1016/j.jchromb.2008.06.039

[41]

Vorst O. Metabolomics (2005) 10.1007/s11306-005-4432-7

[42]

Bristow A. W. T. Rapid Commun. Mass Spectrom. (2004) 10.1002/rcm.1492

[43]

Jansen R. Clin. Biochem. (2005) 10.1016/j.clinbiochem.2004.11.003

[44]

Josephs J. Rapid Commun. Mass Spectrom. (2004) 10.1002/rcm.1402

[45]

Moco S. Plant Physiol. (2006) 10.1104/pp.106.078428

[46]

Weinmann W. Analusis (2000) 10.1051/analusis:2000280934

[47]

Baumann C. Rapid Commun. Mass Spectrom. (2000) 10.1002/(sici)1097-0231(20000315)14:5<349::aid-rcm873>3.0.co;2-p

[48]

Sreekumar A. Nature (2009) 10.1038/nature07762

[49]

Lawton K. A. (2009)

[50]

Lawton K. A. Pharmacogenomics (2008) 10.2217/14622416.9.4.383

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Details

Published: Jul 22, 2009
Vol/Issue: 81(16)
Pages: 6656-6667

Authors

A

Anne M. Evans