Presence of Legacy and Emerging PFAS in Human Liver Specimens Banked in the United States from 2000 to 2024

NHANES NHANES Questionnaires, Datasets, And Related Documentation: Continuous National Health And Nutrition Examination Survey (NHANES) , 2017. https://wwwn.cdc.gov/nchs/nhanes/continuousnhanes/default.aspx?BeginYear=2017.

[5]

Perfluorooctanoic Acid (PFOA) Exposures and Incident Cancers among Adults Living Near a Chemical Plant

Vaughn Barry, Andrea Winquist, Kyle Steenland

Environmental Health Perspectives 10.1289/ehp.1306615

[6]

10.1001/jama.2011.2034

[7]

Thyroid Disrupting Effects of Old and New Generation PFAS

Francesca Coperchini, Laura Croce, Gianluca Ricci et al.

Frontiers in Endocrinology 10.3389/fendo.2020.612320

[8]

10.1289/ehp.1206372

[9]

10.1289/ehp.10506

[10]

10.1002/hep.31483

[11]

10.1016/j.jhepr.2023.100694

[12]

10.1016/j.envint.2019.05.027

[13]

10.1016/j.chemosphere.2013.10.005

[14]

10.1016/j.eehl.2022.05.002

[15]

10.1016/j.ijheh.2025.114542

[16]

10.3390/ijerph20216984

[17]

10.1039/c9em00502a

[18]

10.1016/j.envpol.2015.01.024

[19]

Half-Life of Serum Elimination of Perfluorooctanesulfonate,Perfluorohexanesulfonate, and Perfluorooctanoate in Retired Fluorochemical Production Workers

Geary W. Olsen, Jean M. Burris, David J. Ehresman et al.

Environmental Health Perspectives 10.1289/ehp.10009

[20]

Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water

Tony Fletcher, Daniel Mucs, Kristin Scott et al.

Occupational and Environmental Medicine 10.1136/oemed-2017-104651

[21]

Biomonitoring of Perfluoroalkyl Acids in Human Urine and Estimates of Biological Half-Life

Yifeng Zhang, Sanjay Beesoon, Lingyan Zhu et al.

Environmental Science & Technology 10.1021/es401905e

[22]

Occurrence of Major Perfluorinated Alkylate Substances in Human Blood and Target Organs

Flemming Nielsen, Fabian C. Fischer, Peter M. Leth et al.

Environmental Science & Technology 10.1021/acs.est.3c06499

[23]

10.1016/j.toxlet.2009.07.011

[24]

10.1093/toxsci/kfq219

[25]

10.1093/toxsci/kfw236

[26]

10.1021/acs.est.8b05052

[27]

10.1021/acs.est.0c00175

[28]

Kwiterovich P. O. J. Lipid Res. (1970) 10.1016/s0022-2275(20)42968-2

[29]

10.1007/s00204-024-03789-0

[30]

10.1080/1547691x.2018.1445145

[31]

10.1093/toxsci/68.1.249

[32]

10.1289/ehp11840

[33]

Effects of per- and polyfluoroalkyl substances on the liver: Human-relevant mechanisms of toxicity

Amy Maerten, Ellen Callewaert, Julen Sanz-Serrano et al.

Science of The Total Environment 10.1016/j.scitotenv.2024.176717

[34]

10.1289/ehp10092

[35]

10.1016/j.envint.2022.107108

[36]

10.1016/j.envpol.2024.123544

[37]

10.1016/j.envint.2013.06.004

[38]

10.1016/j.envres.2021.111775

[39]

10.1021/acs.est.3c02765

[40]

10.1093/toxsci/kfp275

[41]

10.1136/bmjopen-2024-089783

[42]

10.1016/j.scitotenv.2022.156891

[43]

10.3892/br.2014.309

[44]

Group, E. W. PFAS contamination in the U.S Retrieved . 2025. https://www.ewg.org/interactive-maps/pfas_contamination/. (accessed 23 June 2025).

[45]

Ganglbauer, J.; Sankey, J.; Agudelo-Areiza, J.; Fabian, F. W.; Slitt, A.; Abele-Bind, M.; Vojta, S.; Becanova, J.; Lohmann, R.; Dekker, H. Data cleaning and QAQC pipeline for targeted PFAS LCMS/MS from Sciex ; Zenodo, 2025. DOI: 10.5281/zenodo.17991560. 10.5281/zenodo.17991560

[46]

10.1021/acs.est.3c04560

[47]

U.S. Environmental Protection Agency (2025)

[48]

10.1021/acs.est.4c04050

[49]

10.1021/es504347u

[50]

10.1007/s11356-015-4202-7

Showing 50 of 83 references

Metrics

0

Citations

83

References

Details

Published: Apr 07, 2026
Vol/Issue: 60(15)
Pages: 11281-11292
License: View

Authors

J

Juliana Agudelo Areiza

Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy; University of Rhode Island

J

Jitka Becanova

Graduate School of Oceanography; University of Rhode Island

S

Simon Vojta

Graduate School of Oceanography; University of Rhode Island

J

Johanna Ganglbauer

Graduate School of Oceanography; University of Rhode Island

U

Udayan Apte

Department of Pharmacology, Toxicology and Therapeutics; University of Kansas Medical Center

L

Luigi Brunetti

Pharmacy Practice and Administration, Ernest Mario School of Pharmacy; Rutgers University

S

Sean Kumer

Department of Surgery; University of Kansas Medical Center

F

Faiz Haque

Harvard School of Engineering and Applied Sciences; Harvard University; University of Vienna

E

Euna Kim

Harvard School of Engineering and Applied Sciences; Harvard University

E

Elsie M. Sunderland

Harvard School of Engineering and Applied Sciences; Harvard University

R

Rainer Lohmann

Graduate School of Oceanography; University of Rhode Island

F

Fabian C. Fischer

Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy; University of Rhode Island

A

Angela Slitt

Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy; University of Rhode Island

Funding

National Institute of General Medical Sciences Award: P20GM103430

National Institute of Environmental Health Sciences Award: P30-ES005022

National Social Science Fund of China Award: OIA-1655221

National Disease Research Interchange (NDRI) Award: SCR 000550

Cite This Article

Juliana Agudelo Areiza, Jitka Becanova, Simon Vojta, et al. (2026). Presence of Legacy and Emerging PFAS in Human Liver Specimens Banked in the United States from 2000 to 2024. Environmental Science & Technology, 60(15), 11281-11292. https://doi.org/10.1021/acs.est.5c14780

Presence of Legacy and Emerging PFAS in Human Liver Specimens Banked in the United States from 2000 to 2024

You May Also Like