Extracellular Matrix Viscosity Reprogramming by In Situ Au Bioreactor-Boosted Microwavegenetics Disables Tumor Escape in CAR-T Immunotherapy

Duo Wang; Mengqi Zhang; Guanhua Qiu; Chao Rong; Xiaoqi Zhu; Guchun Qin; Cunqing Kong; Jing Zhou; Xiayi Liang; Zhaoting Bu; Junjie Liu; Tao Luo; Kun Zhang

doi:10.1021/acsnano.2c10845

journal article Mar 14, 2023

Extracellular Matrix Viscosity Reprogramming by In Situ Au Bioreactor-Boosted Microwavegenetics Disables Tumor Escape in CAR-T Immunotherapy

Duo Wang

Mengqi Zhang

Guanhua Qiu Chao Rong

Xiaoqi Zhu Guchun Qin Cunqing Kong Jing Zhou

Xiayi Liang Zhaoting Bu Junjie Liu

Tao Luo

Kun Zhang

ACS Nano Vol. 17 No. 6 pp. 5503-5516 · American Chemical Society (ACS)

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Details

Published: Mar 14, 2023
Vol/Issue: 17(6)
Pages: 5503-5516
License: View

Authors

D

Duo Wang

Department of Medical Ultrasound, Department of Gastrointestinal Surgery, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University Cancer Hospital, Guangxi Medical University. No. 71 Hedi Road, Nanning 530021, Guangxi, P.R. China

M

Mengqi Zhang

Department of Medical Ultrasound, Department of Gastrointestinal Surgery, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University Cancer Hospital, Guangxi Medical University. No. 71 Hedi Road, Nanning 530021, Guangxi, P.R. China

G

Guanhua Qiu

Department of Medical Ultrasound, Department of Gastrointestinal Surgery, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University Cancer Hospital, Guangxi Medical University. No. 71 Hedi Road, Nanning 530021, Guangxi, P.R. China

C

Chao Rong

Department of Medical Ultrasound, Department of Gastrointestinal Surgery, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University Cancer Hospital, Guangxi Medical University. No. 71 Hedi Road, Nanning 530021, Guangxi, P.R. China

X

Xiaoqi Zhu

Department of Medical Ultrasound, Department of Gastrointestinal Surgery, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University Cancer Hospital, Guangxi Medical University. No. 71 Hedi Road, Nanning 530021, Guangxi, P.R. China

G

Guchun Qin

Department of Medical Ultrasound, Department of Gastrointestinal Surgery, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University Cancer Hospital, Guangxi Medical University. No. 71 Hedi Road, Nanning 530021, Guangxi, P.R. China

C

Cunqing Kong

Department of Medical Ultrasound, Department of Gastrointestinal Surgery, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University Cancer Hospital, Guangxi Medical University. No. 71 Hedi Road, Nanning 530021, Guangxi, P.R. China

J

Jing Zhou

Department of Medical Ultrasound, Department of Gastrointestinal Surgery, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University Cancer Hospital, Guangxi Medical University. No. 71 Hedi Road, Nanning 530021, Guangxi, P.R. China; Central Laboratory, Department of Medical Ultrasound, and Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Tongji University. No. 301 Yanchangzhong Road, Shanghai 200072, P.R. China

X

Xiayi Liang

Department of Medical Ultrasound, Department of Gastrointestinal Surgery, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University Cancer Hospital, Guangxi Medical University. No. 71 Hedi Road, Nanning 530021, Guangxi, P.R. China; Central Laboratory, Department of Medical Ultrasound, and Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Tongji University. No. 301 Yanchangzhong Road, Shanghai 200072, P.R. China

Z

Zhaoting Bu

Department of Medical Ultrasound, Department of Gastrointestinal Surgery, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University Cancer Hospital, Guangxi Medical University. No. 71 Hedi Road, Nanning 530021, Guangxi, P.R. China; Central Laboratory, Department of Medical Ultrasound, and Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Tongji University. No. 301 Yanchangzhong Road, Shanghai 200072, P.R. China

J

Junjie Liu

Department of Medical Ultrasound, Department of Gastrointestinal Surgery, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University Cancer Hospital, Guangxi Medical University. No. 71 Hedi Road, Nanning 530021, Guangxi, P.R. China

T

Tao Luo

Department of Medical Ultrasound, Department of Gastrointestinal Surgery, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University Cancer Hospital, Guangxi Medical University. No. 71 Hedi Road, Nanning 530021, Guangxi, P.R. China

K

Kun Zhang

Department of Medical Ultrasound, Department of Gastrointestinal Surgery, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University Cancer Hospital, Guangxi Medical University. No. 71 Hedi Road, Nanning 530021, Guangxi, P.R. China; Central Laboratory, Department of Medical Ultrasound, and Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Tongji University. No. 301 Yanchangzhong Road, Shanghai 200072, P.R. China

Funding

National Natural Science Foundation of China Award: 81971591

Natural Science Foundation of Guangxi Province Award: 2022GXNSFDA035060

Central University Basic Research Fund of China Award: 22120210561

Shanghai Rising-Star Program Award: 19QA1406800

Shanghai Talent Development Fund Award: 2019040

Shanghai Young Top-Notch Talent

Cite This Article

Duo Wang, Mengqi Zhang, Guanhua Qiu, et al. (2023). Extracellular Matrix Viscosity Reprogramming by In Situ Au Bioreactor-Boosted Microwavegenetics Disables Tumor Escape in CAR-T Immunotherapy. ACS Nano, 17(6), 5503-5516. https://doi.org/10.1021/acsnano.2c10845

Extracellular Matrix Viscosity Reprogramming by In Situ Au Bioreactor-Boosted Microwavegenetics Disables Tumor Escape in CAR-T Immunotherapy

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