A Multifaceted Nanodrug Disrupts the Copper–Iron Homeostasis to Enhance Cancer Radiotherapeutic Effect

Yu Hua; Shichun Cao; Yu Yu; Chengzhen Chu; Ludi Yang; Shengfang Ge; Zhengwei You; Jie Yu

doi:10.1021/acsnano.5c06891

journal article Open Access Jul 10, 2025

A Multifaceted Nanodrug Disrupts the Copper–Iron Homeostasis to Enhance Cancer Radiotherapeutic Effect

Yu Hua

Shichun Cao Yu Yu

Chengzhen Chu Ludi Yang Shengfang Ge Zhengwei You

Jie Yu

ACS Nano Vol. 19 No. 28 pp. 26091-26104 · American Chemical Society (ACS)

View at Publisher Save 10.1021/acsnano.5c06891

Topics

No keywords indexed for this article. Browse by subject →

References

41

[1]

10.6004/jnccn.2017.0047

[2]

10.1016/j.preteyeres.2018.03.004

[3]

10.1158/1078-0432.ccr-20-2452

[4]

Opportunities and challenges of radiotherapy for treating cancer

Dörthe Schaue, William H. McBride

Nature Reviews Clinical Oncology 10.1038/nrclinonc.2015.120

[5]

10.1038/nrclinonc.2012.203

[6]

10.1016/j.tips.2017.11.003

[7]

10.1016/j.bbamcr.2020.118893

[8]

10.1016/j.redox.2021.101900

[9]

10.1016/s1047-2797(03)00119-4

[10]

10.1038/nature13180

[11]

10.1158/0008-5472.can-16-1190

[12]

10.1016/j.freeradbiomed.2020.01.186

[13]

10.1016/j.jhep.2022.01.009

[14]

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al.

Cell 10.1016/j.cell.2012.03.042

[15]

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Brent R. Stockwell

Cell 10.1016/j.cell.2022.06.003

[16]

Targeting ferroptosis as a vulnerability in cancer

Guang Lei, Li Zhuang, Boyi Gan

Nature Reviews Cancer 10.1038/s41568-022-00459-0

[17]

10.1016/j.ccell.2024.03.011

[18]

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

Guang Lei, Yilei Zhang, Pranavi Koppula et al.

Cell Research 10.1038/s41422-019-0263-3

[19]

10.1021/cr400135x

[20]

10.1002/adma.201901402

[21]

Rizk S. L. Cancer Res. (1984)

[22]

Magálová T. Neoplasma (1999)

[23]

10.1385/bter:89:1:1

[24]

Zinc, Copper, and Magnesium and Risks for All-Cause, Cancer, and Cardiovascular Mortality

Nathalie Leone, Dominique Courbon, Pierre Ducimetiere et al.

Epidemiology 10.1097/01.ede.0000209454.41466.b7

[25]

10.1002/ijc.31991

[26]

10.3390/nu13010060

[27]

10.1021/bm200956u

[28]

10.1039/c9cs00373h

[29]

Connecting copper and cancer: from transition metal signalling to metalloplasia

Eva J. Ge, Ashley I. Bush, Angela Casini et al.

Nature Reviews Cancer 10.1038/s41568-021-00417-2

[30]

10.1021/acsnano.4c11455

[31]

Tumor Microenvironment Responsive Hollow Nanoplatform for Triple Amplification of Oxidative Stress to Enhance Cuproptosis‐Based Synergistic Cancer Therapy

Weijun Xu, Yaping Wang, Guanghui Hou et al.

Advanced Healthcare Materials 10.1002/adhm.202202949

[32]

A Hollow Amorphous Bimetal Organic Framework for Synergistic Cuproptosis/Ferroptosis/Apoptosis Anticancer Therapy via Disrupting Intracellular Redox Homeostasis and Copper/Iron Metabolisms

Weijun Xu, Jingchun Qian, Guanghui Hou et al.

Advanced Functional Materials 10.1002/adfm.202205013

[33]

10.1016/j.smaim.2022.11.002

[34]

10.1016/j.smaim.2022.11.006

[35]

10.1016/0002-9343(56)90066-3

[36]

10.1016/s0140-6736(82)92201-2

[37]

10.1158/1078-0432.ccr-16-1326

[38]

10.1016/s2468-1253(22)00270-9

[39]

10.1093/annonc/mds654

[40]

10.1007/s10118-023-3009-0

[41]

10.1007/s10118-021-2625-9

Metrics

4

Citations

41

References

Details

Published: Jul 10, 2025
Vol/Issue: 19(28)
Pages: 26091-26104
License: View

Authors

Y

Yu Hua