Identification of the Molecular Mechanisms by Which the Diterpenoid Salvinorin A Binds to κ-Opioid Receptors

Feng Yan; Philip D. Mosier; Richard B. Westkaemper; Jeremy Stewart; Jordan K. Zjawiony; Timothy A. Vortherms; Douglas J. Sheffler; Bryan L. Roth

doi:10.1021/bi050490d

journal article May 26, 2005

Identification of the Molecular Mechanisms by Which the Diterpenoid Salvinorin A Binds to κ-Opioid Receptors

Philip D. Mosier Richard B. Westkaemper Jeremy Stewart Jordan K. Zjawiony Timothy A. Vortherms Douglas J. Sheffler Bryan L. Roth

Biochemistry Vol. 44 No. 24 pp. 8643-8651 · American Chemical Society (ACS)

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Abbreviations KOR

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Details

Published: May 26, 2005
Vol/Issue: 44(24)
Pages: 8643-8651

Authors

F

Feng Yan

Departments of Biochemistry, Psychiatry, and Neurosciences and Comprehensive Cancer Center, Case Western Reserve University Medical School, Cleveland, Ohio 44106, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, and Department of Pharmacognosy, University of Mississippi, University, Mississippi 38677

P

Philip D. Mosier

Departments of Biochemistry, Psychiatry, and Neurosciences and Comprehensive Cancer Center, Case Western Reserve University Medical School, Cleveland, Ohio 44106, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, and Department of Pharmacognosy, University of Mississippi, University, Mississippi 38677

R

Richard B. Westkaemper

Departments of Biochemistry, Psychiatry, and Neurosciences and Comprehensive Cancer Center, Case Western Reserve University Medical School, Cleveland, Ohio 44106, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, and Department of Pharmacognosy, University of Mississippi, University, Mississippi 38677

J

Jeremy Stewart

Departments of Biochemistry, Psychiatry, and Neurosciences and Comprehensive Cancer Center, Case Western Reserve University Medical School, Cleveland, Ohio 44106, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, and Department of Pharmacognosy, University of Mississippi, University, Mississippi 38677

J

Jordan K. Zjawiony

Departments of Biochemistry, Psychiatry, and Neurosciences and Comprehensive Cancer Center, Case Western Reserve University Medical School, Cleveland, Ohio 44106, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, and Department of Pharmacognosy, University of Mississippi, University, Mississippi 38677

T

Timothy A. Vortherms

Departments of Biochemistry, Psychiatry, and Neurosciences and Comprehensive Cancer Center, Case Western Reserve University Medical School, Cleveland, Ohio 44106, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, and Department of Pharmacognosy, University of Mississippi, University, Mississippi 38677

D

Douglas J. Sheffler

Departments of Biochemistry, Psychiatry, and Neurosciences and Comprehensive Cancer Center, Case Western Reserve University Medical School, Cleveland, Ohio 44106, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, and Department of Pharmacognosy, University of Mississippi, University, Mississippi 38677

B

Bryan L. Roth

Departments of Biochemistry, Psychiatry, and Neurosciences and Comprehensive Cancer Center, Case Western Reserve University Medical School, Cleveland, Ohio 44106, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, and Department of Pharmacognosy, University of Mississippi, University, Mississippi 38677

Cite This Article

Feng Yan, Philip D. Mosier, Richard B. Westkaemper, et al. (2005). Identification of the Molecular Mechanisms by Which the Diterpenoid Salvinorin A Binds to κ-Opioid Receptors. Biochemistry, 44(24), 8643-8651. https://doi.org/10.1021/bi050490d

Identification of the Molecular Mechanisms by Which the Diterpenoid Salvinorin A Binds to κ-Opioid Receptors

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