Extensive Sugar Modification Improves Triple Helix Forming Oligonucleotide Activity in Vitro but Reduces Activity in Vivo

Md. Rowshon Alam; Alokes Majumdar; Arun Kalliat Thazhathveetil; Su-Ting Liu; Ji-Lan Liu; Nitin Puri; Bernard Cuenoud; Shigeki Sasaki; Paul S. Miller; Michael M. Seidman

doi:10.1021/bi7003153

journal article Aug 11, 2007

Extensive Sugar Modification Improves Triple Helix Forming Oligonucleotide Activity in Vitro but Reduces Activity in Vivo

Md. Rowshon Alam Alokes Majumdar Arun Kalliat Thazhathveetil Su-Ting Liu Ji-Lan Liu Nitin Puri Bernard Cuenoud

Shigeki Sasaki Paul S. Miller Michael M. Seidman

Biochemistry Vol. 46 No. 35 pp. 10222-10233 · American Chemical Society (ACS)

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Details

Published: Aug 11, 2007
Vol/Issue: 46(35)
Pages: 10222-10233

Authors

M

Md. Rowshon Alam

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, Novartis Pharmaceuticals Ltd., 4002 Basel, Switzerland, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan, and Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205

A

Alokes Majumdar

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, Novartis Pharmaceuticals Ltd., 4002 Basel, Switzerland, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan, and Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205

A

Arun Kalliat Thazhathveetil

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, Novartis Pharmaceuticals Ltd., 4002 Basel, Switzerland, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan, and Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205

S

Su-Ting Liu

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, Novartis Pharmaceuticals Ltd., 4002 Basel, Switzerland, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan, and Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205

J

Ji-Lan Liu

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, Novartis Pharmaceuticals Ltd., 4002 Basel, Switzerland, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan, and Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205

N

Nitin Puri

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, Novartis Pharmaceuticals Ltd., 4002 Basel, Switzerland, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan, and Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205

B

Bernard Cuenoud

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, Novartis Pharmaceuticals Ltd., 4002 Basel, Switzerland, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan, and Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205

S

Shigeki Sasaki

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, Novartis Pharmaceuticals Ltd., 4002 Basel, Switzerland, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan, and Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205

P

Paul S. Miller

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, Novartis Pharmaceuticals Ltd., 4002 Basel, Switzerland, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan, and Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205

M

Michael M. Seidman

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, Novartis Pharmaceuticals Ltd., 4002 Basel, Switzerland, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan, and Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205

Cite This Article

Md. Rowshon Alam, Alokes Majumdar, Arun Kalliat Thazhathveetil, et al. (2007). Extensive Sugar Modification Improves Triple Helix Forming Oligonucleotide Activity in Vitro but Reduces Activity in Vivo. Biochemistry, 46(35), 10222-10233. https://doi.org/10.1021/bi7003153

Extensive Sugar Modification Improves Triple Helix Forming Oligonucleotide Activity in Vitro but Reduces Activity in Vivo

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