Peroxynitrite Induces Destruction of the Tetrahydrobiopterin and Heme in Endothelial Nitric Oxide Synthase: Transition from Reversible to Irreversible Enzyme Inhibition

Weiguo Chen; Lawrence J. Druhan; Chun-An Chen; Craig Hemann; Yeong-Renn Chen; Vladimir Berka; Ah-Lim Tsai; Jay L. Zweier

doi:10.1021/bi9016632

journal article Mar 17, 2010

Peroxynitrite Induces Destruction of the Tetrahydrobiopterin and Heme in Endothelial Nitric Oxide Synthase: Transition from Reversible to Irreversible Enzyme Inhibition

Weiguo Chen Lawrence J. Druhan Chun-An Chen Craig Hemann Yeong-Renn Chen Vladimir Berka Ah-Lim Tsai Jay L. Zweier

Biochemistry Vol. 49 No. 14 pp. 3129-3137 · American Chemical Society (ACS)

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Published: Mar 17, 2010
Vol/Issue: 49(14)
Pages: 3129-3137

Authors

W

Weiguo Chen

Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210

L

Lawrence J. Druhan

Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210

C

Chun-An Chen

Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210

C

Craig Hemann

Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210

Y

Yeong-Renn Chen

Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210

V

Vladimir Berka

Division of Hematology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030

A

Ah-Lim Tsai

Division of Hematology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030

J

Jay L. Zweier

Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210

Cite This Article

Weiguo Chen, Lawrence J. Druhan, Chun-An Chen, et al. (2010). Peroxynitrite Induces Destruction of the Tetrahydrobiopterin and Heme in Endothelial Nitric Oxide Synthase: Transition from Reversible to Irreversible Enzyme Inhibition. Biochemistry, 49(14), 3129-3137. https://doi.org/10.1021/bi9016632

Peroxynitrite Induces Destruction of the Tetrahydrobiopterin and Heme in Endothelial Nitric Oxide Synthase: Transition from Reversible to Irreversible Enzyme Inhibition

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