The Methylation Effect in Medicinal Chemistry

Eliezer J. Barreiro; Arthur E. Kümmerle; Carlos A. M. Fraga

doi:10.1021/cr200060g

journal article Jun 01, 2011

The Methylation Effect in Medicinal Chemistry

Eliezer J. Barreiro Arthur E. Kümmerle Carlos A. M. Fraga

Chemical Reviews Vol. 111 No. 9 pp. 5215-5246 · American Chemical Society (ACS)

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Published: Jun 01, 2011
Vol/Issue: 111(9)
Pages: 5215-5246

Authors

E

Eliezer J. Barreiro

Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, CCS, Cidade Universitária, CP 68.006, 21941-902 Rio de Janeiro, RJ, Brazil; Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil; Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil

A

Arthur E. Kümmerle

Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, CCS, Cidade Universitária, CP 68.006, 21941-902 Rio de Janeiro, RJ, Brazil; Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil

C

Carlos A. M. Fraga

Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, CCS, Cidade Universitária, CP 68.006, 21941-902 Rio de Janeiro, RJ, Brazil; Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil; Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil

Cite This Article

Eliezer J. Barreiro, Arthur E. Kümmerle, Carlos A. M. Fraga (2011). The Methylation Effect in Medicinal Chemistry. Chemical Reviews, 111(9), 5215-5246. https://doi.org/10.1021/cr200060g

The Methylation Effect in Medicinal Chemistry

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