Efficient, Chemoenzymatic Process for Manufacture of the Boceprevir Bicyclic [3.1.0]Proline Intermediate Based on Amine Oxidase-Catalyzed Desymmetrization

Tao Li; Jack Liang; Alexandre Ambrogelly; Tim Brennan; Guy Gloor; Gjalt Huisman; James Lalonde; Azzeddine Lekhal; Ben Mijts; Sheela Muley; Lisa Newman; Matt Tobin; George Wong; Aleksey Zaks; Xing Zhang

doi:10.1021/ja3010495

journal article Mar 28, 2012

Efficient, Chemoenzymatic Process for Manufacture of the Boceprevir Bicyclic [3.1.0]Proline Intermediate Based on Amine Oxidase-Catalyzed Desymmetrization

Jack Liang Alexandre Ambrogelly Tim Brennan Guy Gloor Gjalt Huisman James Lalonde Azzeddine Lekhal Ben Mijts Sheela Muley Lisa Newman

Matt Tobin George Wong Aleksey Zaks Xing Zhang

Journal of the American Chemical Society Vol. 134 No. 14 pp. 6467-6472 · American Chemical Society (ACS)

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Details

Published: Mar 28, 2012
Vol/Issue: 134(14)
Pages: 6467-6472

Authors

T

Tao Li

Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

J

Jack Liang

Codexis, Inc., 200 Penobscot Drive, Redwood City, California 94063, United States

A

Alexandre Ambrogelly

Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

T

Tim Brennan

Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

G

Guy Gloor

Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

G

Gjalt Huisman

Codexis, Inc., 200 Penobscot Drive, Redwood City, California 94063, United States

J

James Lalonde

Codexis, Inc., 200 Penobscot Drive, Redwood City, California 94063, United States

A

Azzeddine Lekhal

Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

B

Ben Mijts

Codexis, Inc., 200 Penobscot Drive, Redwood City, California 94063, United States

S

Sheela Muley

Codexis, Inc., 200 Penobscot Drive, Redwood City, California 94063, United States

L

Lisa Newman

Codexis, Inc., 200 Penobscot Drive, Redwood City, California 94063, United States

M

Matt Tobin

Codexis, Inc., 200 Penobscot Drive, Redwood City, California 94063, United States

G

George Wong

Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

A

Aleksey Zaks

Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

X

Xing Zhang

Codexis, Inc., 200 Penobscot Drive, Redwood City, California 94063, United States

Cite This Article

Tao Li, Jack Liang, Alexandre Ambrogelly, et al. (2012). Efficient, Chemoenzymatic Process for Manufacture of the Boceprevir Bicyclic [3.1.0]Proline Intermediate Based on Amine Oxidase-Catalyzed Desymmetrization. Journal of the American Chemical Society, 134(14), 6467-6472. https://doi.org/10.1021/ja3010495

Efficient, Chemoenzymatic Process for Manufacture of the Boceprevir Bicyclic [3.1.0]Proline Intermediate Based on Amine Oxidase-Catalyzed Desymmetrization

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