Confronting the Challenging Asymmetric Carbonyl 1,2-Addition Using Vinyl Heteroarene Pronucleophiles: Ligand-Controlled Regiodivergent Processes through a Dearomatized Allyl–Cu Species

Yuyang Dong; Alexander W. Schuppe; Binh Khanh Mai; Peng Liu; Stephen L. Buchwald

doi:10.1021/jacs.2c00734

journal article Mar 26, 2022

Confronting the Challenging Asymmetric Carbonyl 1,2-Addition Using Vinyl Heteroarene Pronucleophiles: Ligand-Controlled Regiodivergent Processes through a Dearomatized Allyl–Cu Species

Yuyang Dong

Journal of the American Chemical Society Vol. 144 No. 13 pp. 5985-5995 · American Chemical Society (ACS)

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Details

Published: Mar 26, 2022
Vol/Issue: 144(13)
Pages: 5985-5995
License: View

Authors

Y

Yuyang Dong

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

A

Alexander W. Schuppe

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

B

Binh Khanh Mai

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States

P

Peng Liu

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States

S

Stephen L. Buchwald

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Funding

National Institute of General Medical Sciences Award: GM058160-17S1

National Science Foundation Award: ACI-1548562

Arnold and Mabel Beckman Foundation

Cite This Article

Yuyang Dong, Alexander W. Schuppe, Binh Khanh Mai, et al. (2022). Confronting the Challenging Asymmetric Carbonyl 1,2-Addition Using Vinyl Heteroarene Pronucleophiles: Ligand-Controlled Regiodivergent Processes through a Dearomatized Allyl–Cu Species. Journal of the American Chemical Society, 144(13), 5985-5995. https://doi.org/10.1021/jacs.2c00734

Confronting the Challenging Asymmetric Carbonyl 1,2-Addition Using Vinyl Heteroarene Pronucleophiles: Ligand-Controlled Regiodivergent Processes through a Dearomatized Allyl–Cu Species

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