Acyl Glucuronides:  Biological Activity, Chemical Reactivity, and Chemical Synthesis

Andrew V. Stachulski; John R. Harding; John C. Lindon; James L. Maggs; B. Kevin Park; Ian D. Wilson

doi:10.1021/jm060599z

journal article Nov 27, 2006

Acyl Glucuronides: Biological Activity, Chemical Reactivity, and Chemical Synthesis

Andrew V. Stachulski John R. Harding John C. Lindon James L. Maggs B. Kevin Park Ian D. Wilson

Journal of Medicinal Chemistry Vol. 49 No. 24 pp. 6931-6945 · American Chemical Society (ACS)

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Details

Published: Nov 27, 2006
Vol/Issue: 49(24)
Pages: 6931-6945

Authors

A

Andrew V. Stachulski

Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, U.K., Drug Metabolism and Pharmacokinetics Department, AstraZeneca U.K. Ltd., Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K., Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K., and Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE, U.K.

J

John R. Harding

Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, U.K., Drug Metabolism and Pharmacokinetics Department, AstraZeneca U.K. Ltd., Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K., Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K., and Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE, U.K.

J

John C. Lindon

Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, U.K., Drug Metabolism and Pharmacokinetics Department, AstraZeneca U.K. Ltd., Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K., Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K., and Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE, U.K.

J

James L. Maggs

Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, U.K., Drug Metabolism and Pharmacokinetics Department, AstraZeneca U.K. Ltd., Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K., Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K., and Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE, U.K.

B

B. Kevin Park

Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, U.K., Drug Metabolism and Pharmacokinetics Department, AstraZeneca U.K. Ltd., Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K., Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K., and Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE, U.K.

I

Ian D. Wilson

Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, U.K., Drug Metabolism and Pharmacokinetics Department, AstraZeneca U.K. Ltd., Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K., Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K., and Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE, U.K.

Cite This Article

Andrew V. Stachulski, John R. Harding, John C. Lindon, et al. (2006). Acyl Glucuronides: Biological Activity, Chemical Reactivity, and Chemical Synthesis. Journal of Medicinal Chemistry, 49(24), 6931-6945. https://doi.org/10.1021/jm060599z

Acyl Glucuronides: Biological Activity, Chemical Reactivity, and Chemical Synthesis

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