Structure-Based Discovery of Inhibitors of Microsomal Prostaglandin E2 Synthase−1, 5-Lipoxygenase and 5-Lipoxygenase-Activating Protein: Promising Hits for the Development of New Anti-inflammatory Agents

Rosa De Simone; Maria Giovanna Chini; Ines Bruno; Raffaele Riccio; Daniela Mueller; Oliver Werz; Giuseppe Bifulco

doi:10.1021/jm101238d

journal article Feb 16, 2011

Structure-Based Discovery of Inhibitors of Microsomal Prostaglandin E2 Synthase−1, 5-Lipoxygenase and 5-Lipoxygenase-Activating Protein: Promising Hits for the Development of New Anti-inflammatory Agents

Rosa De Simone Maria Giovanna Chini Ines Bruno Raffaele Riccio Daniela Mueller Oliver Werz

Giuseppe Bifulco

Journal of Medicinal Chemistry Vol. 54 No. 6 pp. 1565-1575 · American Chemical Society (ACS)

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Details

Published: Feb 16, 2011
Vol/Issue: 54(6)
Pages: 1565-1575

Authors

R

Rosa De Simone

Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy

M

Maria Giovanna Chini

Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy

I

Ines Bruno

Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy

R

Raffaele Riccio

Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy

D

Daniela Mueller

Department of Pharmaceutical Analytics, Pharmaceutical Institute, University of Tuebingen, Auf der Morgenstelle 8, D-72076 Tuebingen, Germany

O

Oliver Werz

Department of Pharmaceutical Analytics, Pharmaceutical Institute, University of Tuebingen, Auf der Morgenstelle 8, D-72076 Tuebingen, Germany

G

Giuseppe Bifulco

Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy

Cite This Article

Rosa De Simone, Maria Giovanna Chini, Ines Bruno, et al. (2011). Structure-Based Discovery of Inhibitors of Microsomal Prostaglandin E2 Synthase−1, 5-Lipoxygenase and 5-Lipoxygenase-Activating Protein: Promising Hits for the Development of New Anti-inflammatory Agents. Journal of Medicinal Chemistry, 54(6), 1565-1575. https://doi.org/10.1021/jm101238d

Structure-Based Discovery of Inhibitors of Microsomal Prostaglandin E2 Synthase−1, 5-Lipoxygenase and 5-Lipoxygenase-Activating Protein: Promising Hits for the Development of New Anti-inflammatory Agents

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