Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3-d]pyrimidine Analogues As Antifolates; Application of Buchwald–Hartwig Aminations of Heterocycles

Aleem Gangjee; Ojas A. Namjoshi; Sudhir Raghavan; Sherry F. Queener; Roy L. Kisliuk; Vivian Cody

doi:10.1021/jm400086g

journal article May 21, 2013

Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3-d]pyrimidine Analogues As Antifolates; Application of Buchwald–Hartwig Aminations of Heterocycles

Aleem Gangjee Ojas A. Namjoshi Sudhir Raghavan Sherry F. Queener Roy L. Kisliuk Vivian Cody

Journal of Medicinal Chemistry Vol. 56 No. 11 pp. 4422-4441 · American Chemical Society (ACS)

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Details

Published: May 21, 2013
Vol/Issue: 56(11)
Pages: 4422-4441

Authors

A

Aleem Gangjee

Division of Medicinal Chemistry, Graduate School Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States

O

Ojas A. Namjoshi

Division of Medicinal Chemistry, Graduate School Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States

S

Sudhir Raghavan

Division of Medicinal Chemistry, Graduate School Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States

S

Sherry F. Queener

Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202, United States

R

Roy L. Kisliuk

Department of Biochemistry, Tufts University Health Science Campus, 136 Harrison Avenue, Boston, Massachusetts 02111, United States

V

Vivian Cody

Hauptman-Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, New York 14203, United States

Cite This Article

Aleem Gangjee, Ojas A. Namjoshi, Sudhir Raghavan, et al. (2013). Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3-d]pyrimidine Analogues As Antifolates; Application of Buchwald–Hartwig Aminations of Heterocycles. Journal of Medicinal Chemistry, 56(11), 4422-4441. https://doi.org/10.1021/jm400086g

Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3-d]pyrimidine Analogues As Antifolates; Application of Buchwald–Hartwig Aminations of Heterocycles

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