Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

Rosemarie O’Shea; Heinz E. Moser

doi:10.1021/jm700967e

journal article Feb 09, 2008

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

Rosemarie O’Shea Heinz E. Moser

Journal of Medicinal Chemistry Vol. 51 No. 10 pp. 2871-2878 · American Chemical Society (ACS)

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References

43

[1]

Allsop A. J. Appl. Microbiol. (2002) 10.1046/j.1365-2672.2002.01483.x

[2]

Rice L. B. Biochem. Pharmacol. (2006) 10.1016/j.bcp.2005.09.018

[3]

Talbot G. H. Clin. Infect. Dis. (2006) 10.1086/499819

[4]

Overbye K. M. Drug Discovery Today (2005) 10.1016/s1359-6446(04)03285-4

[5]

Monaghan R. L. Biochem. Pharmacol. (2006) 10.1016/j.bcp.2005.11.023

[6]

Walsh C. Nat. Rev. Microbiol. (2003) 10.1038/nrmicro727

[7]

Projan S. J. Curr. Opin. Pharmacol. (2002) 10.1016/s1471-4892(02)00197-2

[8]

Silver L. L. IDrugs (2005)

[9]

Payne D. J. Nat. Rev. Drug Discovery (2007) 10.1038/nrd2201

[10]

Macielag, M.Chemical Properties of Antibacterial Drugs. Presented at the45th Interscience Conference for Antimicrobial Agents and Chemotherapy (ICAAC),Washington, DC,December 16–19, 2005.

[11]

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al.

Advanced Drug Delivery Reviews 1997 10.1016/s0169-409x(96)00423-1

[12]

Leeson P. D. J. Med. Chem. (2004) 10.1021/jm049717d

[13]

Garcia-Domenech R. J. Chem. Inf. Comput. Sci. (1998) 10.1021/ci9702454

[14]

Mishra R. K. J. Chem. Inf. Comput. Sci. (2001) 10.1021/ci000303c

[15]

Tomas-Vert F. J. Mol. Struct.: THEOCHEM (2000) 10.1016/s0166-1280(00)00366-3

[16]

Cronin M. T. J. Chem. Inf. Comput. Sci. (2002) 10.1021/ci025501d

[17]

Murcia-Soler M. J. Chem. Inf. Comput. Sci. (2004) 10.1021/ci030340e

[18]

Murcia-Soler M. J. Mol. Graphics Modell. (2003) 10.1016/s1093-3263(02)00184-5

[19]

Molina E. J. Chem. Inf. Comput. Sci. (2004) 10.1021/ci0342019

[20]

Molecular Basis of Bacterial Outer Membrane Permeability Revisited

Hiroshi Nikaido

Microbiology and Molecular Biology Reviews 2003 10.1128/mmbr.67.4.593-656.2003

[21]

Hancock R. E. Trends Microbiol. (1997) 10.1016/s0966-842x(97)81773-8

[22]

Li X. Z. Drugs (2004) 10.2165/00003495-200464020-00004

[23]

Butler M. S. Biochem. Pharmacol. (2006) 10.1016/j.bcp.2005.10.012

[24]

Silver L. L. Acta Hortic. (2006) 10.17660/actahortic.2006.709.13

[25]

Natural Products as Sources of New Drugs over the Last 25 Years

David J. Newman, Gordon M. Cragg

Journal of Natural Products 2007 10.1021/np068054v

[26]

Grabowski K. Curr. Chem. Biol. (2007)

[27]

Molecular Insights into Aminoglycoside Action and Resistance

Sophie Magnet, John S. Blanchard

Chemical Reviews 2005 10.1021/cr0301088

[28]

Zhanel G. G. Drugs (2001) 10.2165/00003495-200161040-00003

[29]

Vaara M. Antimicrob. Agents Chemother. (1993) 10.1128/aac.37.2.354

[30]

Bosnar M. Antimicrob. Agents Chemother. (2005) 10.1128/aac.49.6.2372-2377.2005

[31]

Biegel A. J. Med. Chem. (2005) 10.1021/jm048982w

[32]

Hutter B. Antimicrob. Agents Chemother. (2004) 10.1128/aac.48.8.2838-2844.2004

[33]

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

Christopher A Lipinski, Franco Lombardo, Beryl W Dominy et al.

Advanced Drug Delivery Reviews 2001 10.1016/s0169-409x(00)00129-0

[34]

Bergstroem C. A. S. J. Med. Chem. (2003) 10.1021/jm020986i

[35]

Lead- and drug-like compounds: the rule-of-five revolution

Christopher A. Lipinski

Drug Discovery Today: Technologies 2004 10.1016/j.ddtec.2004.11.007

[36]

Drug-like properties and the causes of poor solubility and poor permeability

Christopher A. Lipinski

Journal of Pharmacological and Toxicological Metho... 2001 10.1016/s1056-8719(00)00107-6

[37]

von Nussbaum F. Angew. Chem., Int. Ed. (2006) 10.1002/anie.200600350

[38]

New antibiotics from bacterial natural products

Jon Clardy, Michael A Fischbach, Christopher T Walsh

Nature Biotechnology 2006 10.1038/nbt1266

[39]

Lorian V. (1996)

[40]

Ohshita, Y.; Yazaki, A.In Vitro Studies with WQ-3034, a Newly Synthesized Acidic Fluoroquinolone. Presented at the37th Interscience Conference for Antimicrobial Agents and Chemotherapy (ICAAC),Toronto, Canada,September 28 through October 1, 1997; Poster F-164.

[41]

Fujikawa K Antimicrob. Agents Chemother. (2005) 10.1128/aac.49.7.3040-3045.2005

[42]

Scorneaux, B.; Arya, A.; Polemeropoulos, A.; Lillard, M.; Han, F.; Amsler, K.; Sonderfan, A. J.; Wang, G.; Wang, Y. C.; Peng, Y.; Xu, G.; Kim, H.; Lien, T.; Phan, L.; Or, Y. S.In Vitro and in Vivo Evaluation of EP-13420: A Novel Ketolide Highly Active against Resistant Pathogens and Having Exceptional Pharmacokinetic Properties in the Dog. Presented at the43rd Interscience Conference for Antimicrobial Agents and Chemotherapy (ICAAC),Chicago, IL,September 14–17, 2003; Poster F-1191.

[43]

Weir, S.; Macone, A.; Donatelli, J.; Trieber, C.; Taylor, D. E.; Tanaka, S. K.; Levy, S. B.The Activity of PTK 0796 against Tetracycline Resistance. Presented at the43rd Interscience Conference for Antimicrobial Agents and Chemotherapy (ICAAC),Chicago, IL,September 14–17, 2003; Poster F-752.

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References

Details

Published: Feb 09, 2008
Vol/Issue: 51(10)
Pages: 2871-2878

Authors

R

Rosemarie O’Shea

Achaogen Pharmaceuticals Inc., 7000 Shoreline Court, South San Francisco, California 94080

H

Heinz E. Moser

Achaogen Pharmaceuticals Inc., 7000 Shoreline Court, South San Francisco, California 94080

Cite This Article

Rosemarie O’Shea, Heinz E. Moser (2008). Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery. Journal of Medicinal Chemistry, 51(10), 2871-2878. https://doi.org/10.1021/jm700967e

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

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