New Horizons for Old Drugs and Drug Leads

Gordon M. Cragg; Paul G. Grothaus; David J. Newman

doi:10.1021/np5000796

journal article Feb 05, 2014

New Horizons for Old Drugs and Drug Leads

Gordon M. Cragg

Paul G. Grothaus David J. Newman

Journal of Natural Products Vol. 77 No. 3 pp. 703-723 · American Chemical Society (ACS)

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References

241

[1]

Newman D. J. Nat. Prod. Rep. (2000) 10.1039/a902202c

[2]

Cragg, G. M.; Newman, D. J.InNew Vistas in Therapeutics from Drug Design to Gene Therapy, Annals of the New York Academy of Sciences;Skarlatos, S. I.; Velletri, P.; Morris, M., Eds.The New York Academy of Sciences:New York, 2001; Vol.953, pp3–25. 10.1111/j.1749-6632.2001.tb11356.x

[3]

Newman, D. J.; Cragg, G. M.InComprehensive Natural Products II Chemistry and Biology;Mander, L.; Lui, H.W., Eds.Elsevier:Oxford, 2010; Vol.2, pp623–650. 10.1016/b978-008045382-8.00055-1

[4]

Newman D. J. Future Med. Chem. (2009) 10.4155/fmc.09.113

[5]

Cragg G. M. Chem. Rev. (2009) 10.1021/cr900019j

[6]

Cragg G. M. (2012)

[7]

Newman, D. J.; Cragg, G. M.; Kingston, D. G. I.InThe Practice of Medicinal Chemistry,3rd ed.Wermuth, C. G., Ed.Academic Press:Amsterdam, 2008; pp159–186. 10.1016/b978-0-12-374194-3.00008-1

[8]

Grothaus P. G. Curr. Org. Chem. (2010) 10.2174/138527210792927708

[9]

Cragg, G. M.; Kingston, D. G. I.; Newman, D. J.InComprehensive Natural Products II Chemistry and Biology;Mander, L.; Lui, H.W., Eds.Elsevier:Oxford, 2010; Vol.2, pp5–39. 10.1016/b978-008045382-8.00033-2

[10]

Newman D. J. Diving Hyperbar. Med. (2009)

[11]

Molinski T. F. Nat. Rev. Drug Discovery (2009) 10.1038/nrd2487

[12]

Martin M. J. J. Am. Chem. Soc. (2013) 10.1021/ja404578u

[13]

Bernardes G. J. L. Angew. Chem., Int. Ed. (2012) 10.1002/anie.201106527

[14]

Newman D. J. Curr. Drug Targets (2006) 10.2174/138945006776054960

[15]

Newman D. J. J. Nat. Prod. (2004) 10.1021/np040031y

[16]

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

David J. Newman, Gordon M. Cragg

Journal of Natural Products 2012 10.1021/np200906s

[17]

Butler M. S. Nat. Prod. Rep. (2008) 10.1039/b514294f

[18]

Baker D. D. Nat. Prod. Rep. (2007) 10.1039/b602241n

[19]

Capon R. J. Curr. Top. Med. Chem. (2012) 10.2174/156802612802652394

[20]

Cragg G. M. Biochim. Biophys. Acta (2013) 10.1016/j.bbagen.2013.02.008

[21]

Newman D. J. Curr. Can. Drug Targets (2002) 10.2174/1568009023333791

[22]

Meijer L. Oncologie (2003)

[23]

Cavalla D. Drug Discovery Today (2013) 10.1016/j.drudis.2012.12.009

[24]

Drug Repurposing: Far Beyond New Targets for Old Drugs

T. I. Oprea, J. Mestres

The AAPS Journal 2012 10.1208/s12248-012-9390-1

[25]

Lipinsky C. A. Drug Discovery Today: Ther. Strategies (2011) 10.1016/j.ddmec.2012.02.002

[26]

Oprea T. I. Drug Discovery Today: Ther. Strategies (2011)

[27]

Aubé J. ACS Med. Chem. Lett. (2012) 10.1021/ml300114c

[28]

Collins F. S. Nat. Rev. Drug Discovery (2011) 10.1038/nrd3461

[29]

Ekins S. Pharm. Res. (2011) 10.1007/s11095-011-0486-6

[30]

Appleby B. S. Dement. Geriatr. Cogn. Disord. (2013) 10.1159/000345791

[31]

Gupta S. C. Trends Pharmacol. Sci. (2013) 10.1016/j.tips.2013.06.005

[32]

Sukhai M. A. Blood (2011) 10.1182/blood-2011-02-315283

[33]

Blatt J. Drug Discovery Today (2013) 10.1016/j.drudis.2012.07.009

[34]

Butts A. PLoS Pathog. (2012) 10.1371/journal.ppat.1002870

[35]

Butts A. Eukaryot. Cell (2013) 10.1128/ec.00314-12

[36]

Expanding the Antimalarial Drug Arsenal—Now, But How?

Brian T. Grimberg, Rajeev K. Mehlotra

Pharmaceuticals 2011 10.3390/ph4050681

[37]

Chopra S. Antimicrob. Chemother. (2011) 10.1093/jac/dkr154

[38]

Nessar R. J. Antimicrob. Chemother. (2012) 10.1093/jac/dkr578

[39]

McAlpine J. B. J. Nat. Prod. (2009) 10.1021/np800742z

[40]

Walsh C. T. J. Am. Chem. Soc. (2010) 10.1021/ja909118a

[41]

Zotchev S. B. Curr. Opin. Biotechnol. (2012) 10.1016/j.copbio.2012.04.002

[42]

Wong F. T. Curr. Opin. Chem. Biol. (2012) 10.1016/j.cbpa.2012.01.018

[43]

Wu M.-C. Curr. Opin. Biotechnol. (2012) 10.1016/j.copbio.2012.03.008

[44]

Van Lanen, S. G.; Shen, B.InAnticancer Agents from Natural Products,2nd ed.Cragg, G. M.; Kingston, D. G. I.; Newman, D. J., Eds.CRC Press/Taylor and Francis:Boca Raton, FL, 2012; pp671–698.

[45]

Njardarson J. T. J. Am. Chem. Soc. (2004) 10.1021/ja039714a

[46]

Wilson R. M. J. Org. Chem. (2006) 10.1021/jo0610053

[47]

Pelish H. E. J. Am. Chem. Soc. (2001) 10.1021/ja016093h

[48]

Blackwell H. E. Chem. Biol. (2001) 10.1016/s1074-5521(01)00085-0

[49]

Clemons P. A. Chem. Biol. (2001) 10.1016/s1074-5521(01)00086-2

[50]

Koehler A. N. J. Am. Chem. Soc. (2003) 10.1021/ja0352698

Showing 50 of 241 references

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Details

Published: Feb 05, 2014
Vol/Issue: 77(3)
Pages: 703-723

Authors

G

Gordon M. Cragg

Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory, P.O. Box B, Frederick, Maryland 21702, United States

P

Paul G. Grothaus

Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory, P.O. Box B, Frederick, Maryland 21702, United States

D

David J. Newman

Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory, P.O. Box B, Frederick, Maryland 21702, United States

Cite This Article

Gordon M. Cragg, Paul G. Grothaus, David J. Newman (2014). New Horizons for Old Drugs and Drug Leads. Journal of Natural Products, 77(3), 703-723. https://doi.org/10.1021/np5000796

New Horizons for Old Drugs and Drug Leads

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