Novel Innovation Systems for a Cellular Approach to Continuous Process Chemistry from Discovery to Market

Thomas Schwalbe; Volker Autze; Michael Hohmann; Wolfgang Stirner

doi:10.1021/op049970n

journal article May 01, 2004

Novel Innovation Systems for a Cellular Approach to Continuous Process Chemistry from Discovery to Market

Thomas Schwalbe Volker Autze Michael Hohmann

Wolfgang Stirner

Organic Process Research & Development Vol. 8 No. 3 pp. 440-454 · American Chemical Society (ACS)

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References

41

[1]

Behr A. Chem. -Ing. -Tech. (2003) 10.1002/cite.200390084

[2]

Ewers C. L. J. Nachr. Chem., Tech. Lab. (2002) 10.1002/nadc.20020501117

[3]

Floyd, T. M.; Kopp, M. W.; Firebaugh, S. L.; Jensen, K. F.; Schmidt, M. A. InProceedingsofthe3rdInternationalConferenceonMicroreactionTechnology(IMRET3), Frankfurt/Main; Ehrfeld, W., Ed.; Springer: Berlin, 1999; p 171. 10.1007/978-3-642-59738-1_16

[4]

Jähnisch K. Angew. Chem., Int. Ed. (2004) 10.1002/anie.200300577

[5]

Schwalbe T. Chimia (2002) 10.2533/000942902777679984

[6]

The breadth of applicability of microreactors was reported: (a) Chambers, R. D.; Spink, R. C. H.Chem.Commun.1999, 883. (b) DeWitt, S. H.Curr.Opin.Chem.Biol.1999,3, 350. (c) Okamoto, H.J.Synth.Org.Chem.Jpn.1999,57, 805. (d) Krummradt, H.; Kopp, U.; Stoldt, J. InProceedingsofthe3rdInternationalConferenceonMicroreactionTechnology(IMRET3), Frankfurt/Main; Ehrfeld, W., Ed.; Springer: Berlin, 1999; p 181. (e) Autze, V.; Kleemann, A.; Golbig, K.Nachr.Chem., Tech.Lab.2000,48, 683. (f) Example reactions are listed at: www.cpc-net.com. (g) Förster, A.Chem.-Ing.-Tech.plus2001,4, 28. (h) Hessel, V.; Löwe, H.Chem.-Ing.Tech.2002,74, 186. (i) Wörz, O.; Jäckel, K. P.; Richter, K. P.; Wolf, A.Chem.Eng.Technol.2001,24, 138. (k) Haswell, S. J.; Middleton, R. J.; O'Sullivan, B.; Skelton, V.; Watts, P.; Styring, P.Chem.Commun.2001, 391. (l) Watts, P.; Wiles, Ch.; Haswell, S. J.; Pombo-Villar, E.Tetrahedron2002,58, 5427. (m) Fletcher, P. D. I.; Haswell, S. J.; E. Pombo-Villar, E.; Warrington, B. H.; Watts, P.; Wong, S. Y. F.; Zhang, X.Tetrahedron2002,58, 4735.

[7]

All CYTOS (2001)

[8]

Taghavi-Moghadam S. Org. Process Res. Dev. (2001) 10.1021/op010066u

[9]

To J. Chem. Eng. Sci. (1996)

[10]

Morrison R. T. (1983)

[11]

Buu-Hoi Ng. P. J. Org. Chem. (1955) 10.1021/jo01123a014

[12]

Bishop W. S. J. Am. Chem. Soc. (1945) 10.1021/ja01228a502

[13]

Fukuyama T.

[14]

Panke G. Synthesis (2003)

[15]

Dale J. D. Org. Process Res. Dev. (2000) 10.1021/op9900683

[16]

(2000)

[17]

Schmalz H. G. (2003)

[18]

Baldyga J. (1999)

[19]

Borune J. R. Org. Process Res. Dev. (2003) 10.1021/op020074q

[20]

Suga S. Chem. Commun. (2003) 10.1039/b211433j

[21]

Yoshida J.

[22]

In J. Am. Chem. Soc. (1955) 10.1021/ja01620a064

[23]

To Chem. Lett. (1990)

[24]

(2000)

[25]

Zhang X. J. Org. Process Res. Dev. (2004) 10.1021/op034193x

[26]

Saboureau C. J. Chem. Soc., Chem. Commun. (1989)

[27]

Schwalbe (2000)

[28]

The J. Am. Chem. Soc. (2001) 10.1021/ja015823i

[29]

Golbig K. (2004)

[30]

Fukuyama T. Org. Lett. (2002) 10.1021/ol0257732

[31]

(b) Liu, S.; Fukuyama, T.; Sato, M.; Ryu, I.Org.ProcessRes.Dev.Submitted for publication.

[32]

Beller, M.; Riermeier, T. H.; Stark, G. InTransitionMetalsforOrganicSynthesis;BuildingBlocksandFineChemicals;Beller, M., Bohm C., Eds.; Wiley-VCH: Weinheim, Germany, 1998; Vol 1, p 208. 10.1002/9783527619399.ch2m

[33]

de Vries A. H. M. J. Org. Lett. (2003) 10.1021/ol035184b

[34]

Also Org. Process Res. Dev. (2004) 10.1021/op034168r

[35]

Yield J. Org. Chem. (1993) 10.1021/jo00069a030

[36]

Hasebe

[37]

Schirrmeister S.

[38]

Matlosz M. (2002)

[39]

Wille

[40]

Wooton R. C. R. J. Lab Chip (2002) 10.1039/b111286d

[41]

Wille

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References

Details

Published: May 01, 2004
Vol/Issue: 8(3)
Pages: 440-454

Authors

T

Thomas Schwalbe

Cellular Process Chemistry, Inc., One Broadway Street, Suite 600, Cambridge, Massachusetts 02142, U.S.A., and CPC - Cellular Process Chemistry Systems GmbH, Hanauer Landstrasse 526, 60343 Frankfurt/Main, Germany

V

Volker Autze

Cellular Process Chemistry, Inc., One Broadway Street, Suite 600, Cambridge, Massachusetts 02142, U.S.A., and CPC - Cellular Process Chemistry Systems GmbH, Hanauer Landstrasse 526, 60343 Frankfurt/Main, Germany

M

Michael Hohmann

Cellular Process Chemistry, Inc., One Broadway Street, Suite 600, Cambridge, Massachusetts 02142, U.S.A., and CPC - Cellular Process Chemistry Systems GmbH, Hanauer Landstrasse 526, 60343 Frankfurt/Main, Germany

W

Wolfgang Stirner

Cellular Process Chemistry, Inc., One Broadway Street, Suite 600, Cambridge, Massachusetts 02142, U.S.A., and CPC - Cellular Process Chemistry Systems GmbH, Hanauer Landstrasse 526, 60343 Frankfurt/Main, Germany

Cite This Article

Thomas Schwalbe, Volker Autze, Michael Hohmann, et al. (2004). Novel Innovation Systems for a Cellular Approach to Continuous Process Chemistry from Discovery to Market. Organic Process Research & Development, 8(3), 440-454. https://doi.org/10.1021/op049970n

Novel Innovation Systems for a Cellular Approach to Continuous Process Chemistry from Discovery to Market

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