Effect of Mild Cognitive Impairment and APOE Genotype on Resting Cerebral Blood Flow and its Association with Cognition

Christina E Wierenga; Sheena I Dev; David D Shin; Lindsay R Clark; Katherine J Bangen; Amy J Jak; Robert A Rissman; Thomas T Liu; David P Salmon; Mark W Bondi

doi:10.1038/jcbfm.2012.58

journal article May 02, 2012

Effect of Mild Cognitive Impairment and APOE Genotype on Resting Cerebral Blood Flow and its Association with Cognition

Christina E Wierenga Sheena I Dev David D Shin Lindsay R Clark Katherine J Bangen Amy J Jak Robert A Rissman Thomas T Liu David P Salmon Mark W Bondi

Journal of Cerebral Blood Flow & Metabolism Vol. 32 No. 8 pp. 1589-1599 · SAGE Publications

View at Publisher Save 10.1038/jcbfm.2012.58

Abstract

Using whole-brain pulsed arterial spin labeling magnetic resonance imaging, resting cerebral blood flow (CBF) was measured in 20 mild cognitive impairment (MCI; 11 ε3 and 9 ε4) and 40 demographically matched cognitively normal (CN; 27 ε3 and 13 ε4) participants. An interaction of apolipoprotein (APOE) genotype ( ε3 and ε4) and cognitive status (CN and MCI) on quantified gray-matter CBF corrected for partial volume effects was found in the left parahippocampal and fusiform gyri (PHG/FG), right middle frontal gyrus, and left medial frontal gyrus. In the PHG/FG, CBF was elevated for CN ε4 carriers but decreased for MCI ε4 carriers. The opposite pattern was seen in frontal regions: CBF was decreased for CN ε4 carriers but increased for MCI ε4 carriers. Cerebral blood flow in the PHG/FG was positively correlated with verbal memory for CN ε4 adults ( r=0.67, P=0.01). Cerebral blood flow in the left medial frontal gyrus was positively correlated with verbal memory for MCI ε4 adults ( r=0.70, P=0.05). Findings support dynamic pathophysiologic processes in the brain associated with Alzheimer's disease risk and indicate that cognitive status and APOE genotype have interactive effects on CBF. Correlations between CBF and verbal memory suggest a differential neurovascular compensatory response in posterior and anterior cortices with cognitive decline in ε4 adults.

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Details

Published: May 02, 2012
Vol/Issue: 32(8)
Pages: 1589-1599
License: View

Authors

C

Christina E Wierenga

Research Service, Veterans Affairs San Diego Healthcare System, San Diego, California, USA; Department of Psychiatry, School of Medicine, University of California San Diego, San Diego, California, USA; Veterans Medical Research Foundation, San Diego, California, USA

S

Sheena I Dev

Research Service, Veterans Affairs San Diego Healthcare System, San Diego, California, USA

D

David D Shin

Department of Radiology, School of Medicine, University of California San Diego, San Diego, California, USA

L

Lindsay R Clark

San Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California San Diego, San Diego, California, USA

K

Katherine J Bangen

Department of Psychiatry, School of Medicine, University of California San Diego, San Diego, California, USA

A

Amy J Jak

Department of Psychiatry, School of Medicine, University of California San Diego, San Diego, California, USA; Psychology Service, Veterans Affairs San Diego Healthcare System, San Diego, California, USA

R

Robert A Rissman

Department of Neurosciences, School of Medicine, University of California San Diego, San Diego, California, USA

T

Thomas T Liu

Department of Radiology, School of Medicine, University of California San Diego, San Diego, California, USA

D

David P Salmon

Department of Neurosciences, School of Medicine, University of California San Diego, San Diego, California, USA

M

Mark W Bondi

Department of Psychiatry, School of Medicine, University of California San Diego, San Diego, California, USA; Psychology Service, Veterans Affairs San Diego Healthcare System, San Diego, California, USA

Cite This Article

Christina E Wierenga, Sheena I Dev, David D Shin, et al. (2012). Effect of Mild Cognitive Impairment and APOE Genotype on Resting Cerebral Blood Flow and its Association with Cognition. Journal of Cerebral Blood Flow & Metabolism, 32(8), 1589-1599. https://doi.org/10.1038/jcbfm.2012.58

Effect of Mild Cognitive Impairment and APOE Genotype on Resting Cerebral Blood Flow and its Association with Cognition

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