Xiamenmycin Attenuates Hypertrophic Scars by Suppressing Local Inflammation and the Effects of Mechanical Stress

Xiao-Jin Liu; Min-Juan Xu; Si-Teng Fan; Zheng Wu; Jun Li; Xiao-mei Yang; Ya-Hui Wang; Jun Xu; Zhi-gang Zhang

doi:10.1038/jid.2012.486

journal article Open Access May 01, 2013

Xiamenmycin Attenuates Hypertrophic Scars by Suppressing Local Inflammation and the Effects of Mechanical Stress

Xiao-Jin Liu Min-Juan Xu Si-Teng Fan Zheng Wu

Jun Li

Xiao-mei Yang Ya-Hui Wang Jun Xu

Zhi-gang Zhang

Journal of Investigative Dermatology Vol. 133 No. 5 pp. 1351-1360 · Elsevier BV

View at Publisher Save 10.1038/jid.2012.486

Topics

No keywords indexed for this article. Browse by subject →

References

50

[1]

Aarabi "Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis" FASEB J (2007) 10.1096/fj.07-8218com

[2]

Aarabi "Hypertrophic scar formation following burns and trauma: new approaches to treatment" PLoS Med (2007) 10.1371/journal.pmed.0040234

[3]

Cabrera-Benitez "Mechanical stress induces lung fibrosis by epithelial-mesenchymal transition" Crit Care Med (2012) 10.1097/ccm.0b013e31822f09d7

[4]

Clayton "Cellular activation through the ligation of intercellular adhesion molecule-1" J Cell Sci (1998) 10.1242/jcs.111.4.443

[5]

Diez "Mechanisms of cardiac fibrosis in hypertension" J Clin Hypertens (2007) 10.1111/j.1524-6175.2007.06626.x

[6]

Tissue Cells Feel and Respond to the Stiffness of Their Substrate

Dennis E. Discher, Paul Janmey, Yu-li Wang

Science 2005 10.1126/science.1116995

[7]

Du "Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis" Cancer Res (2009) 10.1158/0008-5472.can-08-3393

[8]

Eckes "Cell-matrix interactions in dermal repair and scarring" Fibrogenesis Tissue Repair (2010) 10.1186/1755-1536-3-4

[9]

Eming "Inflammation in wound repair: molecular and cellular mechanisms" J Invest Dermatol (2007) 10.1038/sj.jid.5700701

[10]

Follonier "Myofibroblast communication is controlled by intercellular mechanical coupling" J Cell Sci (2008) 10.1242/jcs.024521

[11]

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Gerd G. Gauglitz, Hans C. Korting, Tatiana Pavicic et al.

Molecular Medicine 2011 10.2119/molmed.2009.00153

[12]

Georges "Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis" Am J Physiol-Gastr L (2007)

[13]

Gojo "The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats" Eur J Pharmacol (2007) 10.1016/j.ejphar.2007.04.011

[14]

Gurtner "Improving cutaneous scar formation by controlling the mechanical environment: large animal and phase I studies" Ann Surg (2011) 10.1097/sla.0b013e318220b159

[15]

Hemnes "PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation" Am J Physiol-Lung C (2008) 10.1152/ajplung.00245.2007

[16]

Hinz "Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: implications for the pathogenesis and treatment of fibrosis" Curr Rheumatol Rep (2009) 10.1007/s11926-009-0017-1

[17]

Hinz "Alpha-smooth muscle actin expression upregulates fibroblast contractile activity" Mol Biol Cell (2001) 10.1091/mbc.12.9.2730

[18]

Hinz "Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation" Am J Pathol (2001) 10.1016/s0002-9440(10)61776-2

[19]

Hubbard "Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades" Free Radic Biol Med (2000) 10.1016/s0891-5849(00)00223-9

[20]

Hundhausen "The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion" Blood (2003) 10.1182/blood-2002-12-3775

[21]

Kawamura (2000)

[22]

Kessler "Fibroblasts in mechanically stressed collagen lattices assume a “synthetic” phenotype" J Biol Chem (2001) 10.1074/jbc.m101602200

[23]

Lawrence "Epidemiology and impact of scarring after burn injury: a systematic review of the literature" J Burn Care Res (2012) 10.1097/bcr.0b013e3182374452

[24]

Li "Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture" Hepatology (2007) 10.1002/hep.21792

[25]

Long "ICAM-1: getting a grip on leukocyte adhesion" J Immunol (2011) 10.4049/jimmunol.1100646

[26]

Mustoe "International clinical recommendations on scar management" Plast Reconstr Surg (2002) 10.1097/00006534-200208000-00031

[27]

Nagatoya "Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction" Kidney Int (2002) 10.1046/j.1523-1755.2002.00328.x

[28]

Ogawa "The most current algorithms for the treatment and prevention of hypertrophic scars and keloids" Plast Reconstr Surg (2010) 10.1097/prs.0b013e3181c82dd5

[29]

Ogawa "The relationship between skin stretching/contraction and pathologic scarring: the important role of mechanical forces in keloid generation" Wound Repair Regen (2012) 10.1111/j.1524-475x.2012.00766.x

[30]

Pfaff "Different effect of Toxoplasma gondii infection on adhesion capacity of fibroblasts and monocytes" Parasite Immunol (2008) 10.1111/j.1365-3024.2008.01047.x

[31]

Profyris "Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics Part I. The molecular basis of scar formation" J Am Acad Dermatol (2012) 10.1016/j.jaad.2011.05.055

[32]

Rohatgi "Intratubular hydrodynamic forces influence tubulointerstitial fibrosis in the kidney" Curr Opin Nephrol Hy (2010) 10.1097/mnh.0b013e32833327f3

[33]

Ruperez "HMG-CoA reductase inhibitors decrease angiotensin-II-induced vascular fibrosis—role of RhoA/ROCK and MAPK pathways" Hypertension (2007) 10.1161/hypertensionaha.107.091264

[34]

Sarrazy "Mechanisms of pathological scarring: role of myofibroblasts and current developments" Wound Repair Regeneration (2011)

[35]

Sonomura "The kinase Pyk2 is involved in renal fibrosis by means of mechanical stretch-induced growth factor expression in renal tubules" Kidney Int (2012) 10.1038/ki.2011.403

[36]

Steinhauser "Macrophage/fibroblast coculture induces macrophage inflammatory protein-1alpha production mediated by intercellular adhesion molecule-1 and oxygen radicals" J Leukoc Biol (1998) 10.1002/jlb.64.5.636

[37]

Stramer "The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair" J Invest Dermatol (2007) 10.1038/sj.jid.5700811

[38]

Tziotzios "Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics Part II. Strategies to reduce scar formation after dermatologic procedures" J Am Acad Dermatol (2012) 10.1016/j.jaad.2011.08.035

[39]

Van Loey "Psychopathology and psychological problems in patients with burn scars: epidemiology and management" Am J Clin Dermatol (2003) 10.2165/00128071-200304040-00004

[40]

Vedrenne "The complex dialogue between (myo)fibroblasts and the extracellular matrix during skin repair processes and ageing" Pathol Biol (2012) 10.1016/j.patbio.2011.10.002

[41]

Wang "Increased TGF-beta-producing CD4+ T lymphocytes in postburn patients and their potential interaction with dermal fibroblasts in hypertrophic scarring" Wound Repair Regen (2007) 10.1111/j.1524-475x.2007.00261.x

[42]

Wells "The role of matrix stiffness in hepatic stellate cell activation and liver fibrosis" J Clin Gastroenterol (2005) 10.1097/01.mcg.0000155516.02468.0f

[43]

Wong "Mechanical force prolongs acute inflammation via T-cell-dependent pathways during scar formation" FASEB J (2011) 10.1096/fj.10-178087

[44]

Wu "Inhibitory effects of essential oil from rhizomes of Ligusticum chuanxiong on hypertrophic scarring in the rabbit ear model" Pharm Biol (2011) 10.3109/13880209.2010.542761

[45]

Wynn "Fibrotic disease and the T(H)1/T(H)2 paradigm" Nat Rev Immunol (2004) 10.1038/nri1412

[46]

Wynn "Macrophages: master regulators of inflammation and fibrosis" Semin Liver Dis (2010) 10.1055/s-0030-1255354

[47]

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

Thomas A Wynn, Thirumalai R Ramalingam

Nature Medicine 2012 10.1038/nm.2807

[48]

Xu "Identification and characterization of an anti-fibrotic benzopyran compound isolated from mangrove-derived Streptomyces xiamenensis" Mar Drugs (2012) 10.3390/md10030639

[49]

Zhang "Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of alpha(2)beta(1) integrin" J Cell Sci (2006) 10.1242/jcs.02921

[50]

Zhang "Effects of constitutively active GTPases on fibroblast behavior" Cell Mol Life Sci (2006) 10.1007/s00018-005-5416-5

Metrics

50

Citations

50

References

Details

Published: May 01, 2013
Vol/Issue: 133(5)
Pages: 1351-1360
License: View

Authors

Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China

ShanghaiTech University

Guangdong Medical College

Z

Zhi-gang Zhang

Cite This Article

Xiao-Jin Liu, Min-Juan Xu, Si-Teng Fan, et al. (2013). Xiamenmycin Attenuates Hypertrophic Scars by Suppressing Local Inflammation and the Effects of Mechanical Stress. Journal of Investigative Dermatology, 133(5), 1351-1360. https://doi.org/10.1038/jid.2012.486

Xiamenmycin Attenuates Hypertrophic Scars by Suppressing Local Inflammation and the Effects of Mechanical Stress

You May Also Like