journal article Open Access Jan 01, 2017

Core 1– and 3–derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice

Mucosal Immunology Vol. 10 No. 1 pp. 91-103 · Elsevier BV
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References
49
[1]
Ford "Ulcerative colitis" BMJ (2013) 10.1136/bmj.f432
[2]
Strober "The fundamental basis of inflammatory bowel disease" J. Clin. Invest. (2007) 10.1172/jci30587
[3]
Johansson "The gastrointestinal mucus system in health and disease" Nat. Rev. Gastroenterol. Hepatol. (2013) 10.1038/nrgastro.2013.35
[4]
Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine

Ruth E. Ley, Daniel A. Peterson, Jeffrey I. Gordon

Cell 2006 10.1016/j.cell.2006.02.017
[5]
Pelaseyed "The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system" Immunol. Rev. (2014) 10.1111/imr.12182
[6]
Ambort "Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin" Proc. Natl. Acad. Sci. USA (2012) 10.1073/pnas.1120269109
[7]
Johansson "The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions" Proc. Natl. Acad. Sci. USA (2010)
[8]
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Malin E. V. Johansson, Mia Phillipson, Joel Petersson et al.

Proceedings of the National Academy of Sciences 2008 10.1073/pnas.0803124105
[9]
Allen "The MUC2 gene product: a human intestinal mucin" Int. J. Biochem. Cell. Biol. (1998) 10.1016/s1357-2725(98)00028-4
[10]
Fu "Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice" J. Clin. Invest. (2011) 10.1172/jci45538
[11]
Larsson "Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation" Inflamm. Bowel Dis. (2011) 10.1002/ibd.21625
[12]
Van der Sluis "Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection" Gastroenterology (2006) 10.1053/j.gastro.2006.04.020
[13]
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3–derived O-glycans

Guangyu An, Bo Wei, Baoyun Xia et al.

The Journal of Experimental Medicine 2007 10.1084/jem.20061929
[14]
Brockhausen, I. Biosynthesis of Mucin-Type O-glycans in Comprehensive Glycoscience Editor-in-Chief: J.P. Kamerling; eds G Boons et al.) Vol. 3: 33–59 (Elsevier, Boston, USA, 2007). 10.1016/b978-044451967-2/00035-0
[15]
Xia "Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans" J. Cell. Biol. (2004) 10.1083/jcb.200311112
[16]
Hang "The chemistry and biology of mucin-type O-linked glycosylation" Bioorg. Med. Chem. (2005) 10.1016/j.bmc.2005.04.085
[17]
Robbe "Structural diversity and specific distribution of O-glycans in normal human mucins along the intestinal tract" Biochem. J. (2004) 10.1042/bj20040605
[18]
Rakoff-Nahoum "Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis" Cell (2004) 10.1016/j.cell.2004.07.002
[19]
Png "Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria" Am. J. Gastroenterol. (2010) 10.1038/ajg.2010.281
[20]
Norrsell "N-linked glycopeptides with blood group determinants lacking neuraminic acid from the epithelial cells of rat small and large intestine" Eur. J. Biochem. (1992) 10.1111/j.1432-1033.1992.tb19858.x
[21]
Barthel "Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host" Infect. Immun. (2003) 10.1128/iai.71.5.2839-2858.2003
[22]
Bergstrom "Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa" PLoS Pathog. (2010) 10.1371/journal.ppat.1000902
[23]
Waksman "Streptomycin: background, isolation, properties, and utilization" Science (1953) 10.1126/science.118.3062.259
[24]
Miller "Changes in the mouse's enteric microflora associated with enhanced susceptibility to Salmonella infection following streptomycin treatment" J. Infect. Dis. (1963) 10.1093/infdis/113.1.59
[25]
Rhodes "Faecal mucus degrading glycosidases in ulcerative colitis and Crohn's disease" Gut (1985) 10.1136/gut.26.8.761
[26]
Dwarakanath "Faecal mucinase activity assessed in inflammatory bowel disease using 14C threonine labelled mucin substrate" Gut (1995) 10.1136/gut.37.1.58
[27]
Xu "Inaugural article: honor thy symbionts" Proc. Natl. Acad. Sci. USA (2003) 10.1073/pnas.1734063100
[28]
Wang "Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon" PLoS One (2010) 10.1371/journal.pone.0013607
[29]
Hu "Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins" Am. J. Physiol. Gastrointest. Liver Physiol. (2010) 10.1152/ajpgi.00357.2010
[30]
Sonnenburg "Glycan foraging in vivo by an intestine-adapted bacterial symbiont" Science (2005) 10.1126/science.1109051
[31]
Martens "Coordinate regulation of glycan degradation and polysaccharide capsule biosynthesis by a prominent human gut symbiont" J. Biol. Chem. (2009) 10.1074/jbc.m109.008094
[32]
Martens "Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont" Cell Host Microbe (2008) 10.1016/j.chom.2008.09.007
[33]
Zhang "O-glycosylation regulates polarized secretion by modulating Tango1 stability" Proc. Natl. Acad. Sci. USA (2014) 10.1073/pnas.1322264111
[34]
Perez-Munoz "Discordance between changes in the gut microbiota and pathogenicity in a mouse model of spontaneous colitis" Gut Microbes (2014) 10.4161/gmic.28622
[35]
Sommer "Altered mucus glycosylation in core 1 o-glycan-deficient mice affects microbiota composition and intestinal architecture" PLoS One (2014) 10.1371/journal.pone.0085254
[36]
Kashyap "Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota" Proc. Natl. Acad. Sci. USA (2013) 10.1073/pnas.1306070110
[37]
Rausch "Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype" Proc. Natl. Acad. Sci. USA (2011) 10.1073/pnas.1106408108
[38]
McGovern "Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease" Hum. Mol. Genet. (2010) 10.1093/hmg/ddq248
[39]
Wenzel "Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis" PLoS One (2014) 10.1371/journal.pone.0100217
[40]
Every "Muc1 limits Helicobacter felis binding to gastric epithelial cells but does not limit colonization and gastric pathology following infection" Helicobacter (2008) 10.1111/j.1523-5378.2008.00644.x
[41]
McAuley "MUC1 cell surface mucin is a critical element of the mucosal barrier to infection" J. Clin. Invest. (2007) 10.1172/jci26705
[42]
Rakoff-Nahoum "Role of Toll-like receptors in spontaneous commensal-dependent colitis" Immunity (2006) 10.1016/j.immuni.2006.06.010
[43]
Nenci "Epithelial NEMO links innate immunity to chronic intestinal inflammation" Nature (2007) 10.1038/nature05698
[44]
Vijay-Kumar "Deletion of TLR5 results in spontaneous colitis in mice" J. Clin. Invest. (2007)
[45]
Johansson "Analysis of assembly of secreted mucins" Methods Mol. Biol. (2012) 10.1007/978-1-61779-513-8_6
[46]
Wlodarska "Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis" Infect. Immun. (2011) 10.1128/iai.01104-10
[47]
Development of 16S rRNA-Gene-Targeted Group-Specific Primers for the Detection and Identification of Predominant Bacteria in Human Feces

Takahiro Matsuki, Koichi Watanabe, Junji Fujimoto et al.

Applied and Environmental Microbiology 2002 10.1128/aem.68.11.5445-5451.2002
[48]
Heazlewood "Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis" PLoS medicine (2008) 10.1371/journal.pmed.0050054
[49]
NIH Image to ImageJ: 25 years of image analysis

Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri

Nature Methods 2012 10.1038/nmeth.2089
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Published
Jan 01, 2017
Vol/Issue
10(1)
Pages
91-103
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K. Bergstrom, J. Fu, M E V Johansson, et al. (2017). Core 1– and 3–derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice. Mucosal Immunology, 10(1), 91-103. https://doi.org/10.1038/mi.2016.45