Genome-wide association scan for five major dimensions of personality

A Terracciano; S Sanna; M Uda; B Deiana; G Usala; F Busonero; A Maschio; M Scally; N Patriciu; W-M Chen; M A Distel; E P Slagboom; D I Boomsma; S Villafuerte; E Śliwerska; M Burmeister; N Amin; A C J W Janssens; C M van Duijn; D Schlessinger; G R Abecasis; P T Costa

doi:10.1038/mp.2008.113

journal article Oct 28, 2008

Genome-wide association scan for five major dimensions of personality

A Terracciano S Sanna M Uda B Deiana G Usala F Busonero A Maschio M Scally N Patriciu W-M Chen M A Distel E P Slagboom D I Boomsma S Villafuerte E Śliwerska M Burmeister N Amin A C J W Janssens C M van Duijn D Schlessinger G R Abecasis P T Costa

Molecular Psychiatry Vol. 15 No. 6 pp. 647-656 · Springer Science and Business Media LLC

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References

95

[1]

Bouchard TJ, Loehlin JC . Genes, evolution, and personality. Behav Genet 2001; 31: 243–273. 10.1023/a:1012294324713

[2]

Jang KL, McCrae RR, Angleitner A, Riemann R, Livesley WJ . Heritability of facet-level traits in a cross-cultural twin sample: support for a hierarchical model of personality. J Pers Soc Psychol 1998; 74: 1556–1565. 10.1037/0022-3514.74.6.1556

[3]

Pilia G, Chen WM, Scuteri A, Orrú M, Albai G, Dei M et al. Heritability of cardiovascular and personality traits in 6148 sardinians. PloS Genet 2006; 2: e132. 10.1371/journal.pgen.0020132

[4]

Fullerton J, Cubin M, Tiwari H, Wang C, Bomhra A, Davidson S et al. Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism. Am J Hum Genet 2003; 72: 879–890. 10.1086/374178

[5]

Nash MW, Huezo-Diaz P, Williamson RJ, Sterne A, Purcell S, Hoda F et al. Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships. Hum Mol Genet 2004; 13: 2173–2182. 10.1093/hmg/ddh239

[6]

Neale BM, Sullivan PF, Kendler KS . A genome scan of neuroticism in nicotine dependent smokers. Am J Med Genet B Neuropsychiatr Genet 2005; 132: 65–69. 10.1002/ajmg.b.30095

[7]

Kuo PH, Neale MC, Riley BP, Patterson DG, Walsh D, Prescott CA et al. A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence. Am J Med Genet B Neuropsychiatr Genet 2007; 144: 463–468. 10.1002/ajmg.b.30478

[8]

Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007; 3: e115B. 10.1371/journal.pgen.0030115

[9]

Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889–894. 10.1126/science.1141634

[10]

Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JR et al. A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet 2007; 39: 1245–1250. 10.1038/ng2121

[11]

Sanna S, Jackson AU, Nagaraja R, Willer CJ, Chen WM, Bonnycastle LL et al. Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet 2008; 40: 198–203. 10.1038/ng.74

[12]

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

Richard H. Duerr, Kent D. Taylor, Steven R. Brant et al.

Science 2006 10.1126/science.1135245

[13]

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Paul R. Burton, David G. Clayton, Lon R. Cardon et al.

Nature 2007 10.1038/nature05911

[14]

Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006; 38: 320–323. 10.1038/ng1732

[15]

Shifman S, Bhomra A, Smiley S, Wray NR, James MR, Martin NG et al. A whole genome association study of neuroticism using DNA pooling. Mol Psychiatry 2008; 13: 302–312. 10.1038/sj.mp.4002048

[16]

McCrae RR, Costa Jr PT . Personality in Adulthood: A Five-Factor Theory Perspective, 2nd edn. Guilford Press: New York, 2003. 10.4324/9780203428412

[17]

McCrae RR, Terracciano A . 78 members of the personality profiles of cultures Project. Universal features of personality traits from the observer's perspective: data from 50 cultures. J Pers Soc Psychol 2005; 88: 547–561. 10.1037/0022-3514.88.3.547

[18]

Costa Jr PT, Terracciano A, McCrae RR . Gender differences in personality traits across cultures: robust and surprising findings. J Pers Soc Psychol 2001; 81: 322–331. 10.1037/0022-3514.81.2.322

[19]

McCrae RR, Costa Jr PT, de Lima MP, Simões A, Ostendorf F, Angleitner A et al. Age differences in personality across the adult life span: parallels in five cultures. Dev Psychol 1999; 35: 466–477. 10.1037/0012-1649.35.2.466

[20]

Paunonen SV . Big five factors of personality and replicated predictions of behavior. J Pers Soc Psychol 2003; 84: 411–424. 10.1037/0022-3514.84.2.411

[21]

Ozer DJ, Benet-Martinez V . Personality and the prediction of consequential outcomes. Annu Rev Psychol 2006; 57: 8.1–8.21. 10.1146/annurev.psych.57.102904.190127

[22]

Costa Jr PT, McCrae RR . Influence of extraversion and neuroticism on subjective well-being: happy and unhappy people. J Pers Soc Psychol 1980; 38: 668–678. 10.1037/0022-3514.38.4.668

[23]

Chamorro-Premuzic T, Furnham A . Personality traits and academic examination performance. Eur J Pers 2003; 17: 237–250. 10.1002/per.473

[24]

Gottfredson GD, Jones EM, Holland JL . Personality and vocational interests: the relation of Holland's six interest dimensions to the five robust dimensions of personality. J Couns Psychol 1993; 40: 518–524. 10.1037/0022-0167.40.4.518

[25]

Kelly EL, Conley JJ . Personality and compatibility: a prospective analysis of marital stability and marital satisfaction. J Pers Soc Psychol 1987; 52: 27–40. 10.1037/0022-3514.52.1.27

[26]

Terracciano A, Lockenhoff CE, Crum RM, Bienvenu OJ, Costa Jr PT . Five-factor model personality profiles of drug users. BMC Psychiatry 2008; 8: 22. 10.1186/1471-244x-8-22

[27]

Trobst KK, Herbst JH, Masters III HL, Costa Jr PT . Personality pathways to unsafe sex: personality, condom use, and HIV risk behaviors. J Res Pers 2002; 36: 117–133. 10.1006/jrpe.2001.2334

[28]

Terracciano A, Lockenhoff CE, Zonderman AB, Ferrucci L, Costa Jr PT . Personality predictors of longevity: activity, emotional stability, and conscientiousness. Psychosom Med 2008; 70: 621–627. 10.1097/psy.0b013e31817b9371

[29]

Widiger TA, Costa Jr PT, McCrae RR . A proposal for Axis II: diagnosing personality disorders using the Five-Factor Model. In: Costa Jr PT, Widiger TA (eds). Personality Disorders and the Five-Factor Model of Personality, 2nd edn. American Psychological Association: Washington, DC, 2002, pp 431–456. 10.1037/10423-025

[30]

Widiger TA, Trull TJ . Plate tectonics in the classification of personality disorder: shifting to a dimensional model. Am Psychol 2007; 62: 71–83. 10.1037/0003-066x.62.2.71

[31]

Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ . A longitudinal twin study of personality and major depression in women. Arch Gen Psychiatry 1993; 50: 853–862. 10.1001/archpsyc.1993.01820230023002

[32]

Dinzeo TJ, Docherty NM . Normal personality characteristics in schizophrenia: a review of the literature involving the FFM. J Nerv Ment Dis 2007; 195: 421–429. 10.1097/01.nmd.0000253795.69089.ec

[33]

Bagby RM, Rector NA, Bindseil K, Dickens SE, Levitan RD, Kennedy SH . Self-report ratings and informant ratings of personalities of depressed outpatients. Am J Psychiatry 1998; 155: 437–438. 10.1176/ajp.155.3.437

[34]

Kendler KS, Gatz M, Gardner CO, Pedersen NL . Personality and major depression: a Swedish longitudinal, population-based twin study. Arch Gen Psychiatry 2006; 63: 1113–1120. 10.1001/archpsyc.63.10.1113

[35]

Fanous A, Gardner CO, Prescott CA, Cancro R, Kendler KS . Neuroticism, major depression and gender: a population-based twin study. Psychol Med 2002; 32: 719–728. 10.1017/s003329170200541x

[36]

Hettema JM, Neale MC, Myers JM, Prescott CA, Kendler KS . A population-based twin study of the relationship between neuroticism and internalizing disorders. Am J Psychiatry 2006; 163: 857–864. 10.1176/ajp.2006.163.5.857

[37]

Savitz JB, Cupido CL, Ramesar RS . Trends in suicidology: personality as an endophenotype for molecular genetic investigations. PLoS Med 2006; 3: e107. 10.1371/journal.pmed.0030107

[38]

Costa Jr PT, McCrae RR . Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) Professional Manual. Psychological Assessment Resources: Odessa, FL, 1992.

[39]

Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W et al. Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of {beta}-thalassemia. Proc Natl Acad Sci USA 2008; 105: 1620–1625. 10.1073/pnas.0711566105

[40]

Li S, Sanna S, Maschio A, Busonero F, Usala G, Mulas A et al. The GLUT9 gene is associated with serum uric acid levels in sardinia and chianti cohorts. PLoS Genet 2007; 3: e194. 10.1371/journal.pgen.0030194

[41]

Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 2008; 40: 161–169. 10.1038/ng.76

[42]

Service S, DeYoung J, Karayiorgou M, Roos JL, Pretorious H, Bedoya G et al. Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies. Nat Genet 2006; 38: 556–560. 10.1038/ng1770

[43]

Costa Jr PT, Terracciano A, Uda M, Vacca L, Mameli C, Pilia G et al. Personality traits in Sardinia: testing founder population effects on trait means and variances. Behav Genet 2007; 37: 376–387. 10.1007/s10519-006-9103-6

[44]

Terracciano A . The Italian version of the NEO PI-R: conceptual and empirical support for the use of targeted rotation. Pers Indiv Differ 2003; 35: 1859–1872. 10.1016/s0191-8869(03)00035-7

[45]

Terracciano A, Costa PTJ, McCrae RR . Personality plasticity after age 30. Pers Soc Psychol Bull 2006; 32: 999–1009. 10.1177/0146167206288599

[46]

Yamagata S, Suzuki A, Ando J, Ono Y, Kijima N, Yoshimura K et al. Is the genetic structure of human personality universal? A cross-cultural twin study from North America, Europe, and Asia. J Pers Soc Psychol 2006; 90: 987–998. 10.1037/0022-3514.90.6.987

[47]

Chen WM, Abecasis GR . Family-based association tests for genomewide association scans. Am J Hum Genet 2007; 81: 913–926. 10.1086/521580

[48]

Wigginton JE, Cutler DJ, Abecasis GR . A note on exact tests of Hardy–Weinberg equilibrium. Am J Hum Genet 2005; 76: 887–893. 10.1086/429864

[49]

Wigginton JE, Abecasis GR . PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data. Bioinformatics 2005; 21: 3445–3447. 10.1093/bioinformatics/bti529

[50]

Abecasis GR, Cardon LR, Cookson WO . A general test of association for quantitative traits in nuclear families. Am J Hum Genet 2000; 66: 279–292. 10.1086/302698

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Published: Oct 28, 2008
Vol/Issue: 15(6)
Pages: 647-656
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Cite This Article

A Terracciano, S Sanna, M Uda, et al. (2008). Genome-wide association scan for five major dimensions of personality. Molecular Psychiatry, 15(6), 647-656. https://doi.org/10.1038/mp.2008.113

Genome-wide association scan for five major dimensions of personality

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