Frontal and stealth attack strategies in microbial pathogenesis

D. Scott Merrell; Stanley Falkow

doi:10.1038/nature02760

journal article Open Access Jul 08, 2004

Frontal and stealth attack strategies in microbial pathogenesis

D. Scott Merrell Stanley Falkow

Nature Vol. 430 No. 6996 pp. 250-256 · Springer Science and Business Media LLC

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References

66

[1]

Kaper, J. B., Fasano, A. & Trucksis, M. in Vibrio cholerae and Cholera: Molecular to Global Perspectives (eds Wachsmuth, I. K., Blake, P. A. & Olsvik, Ø.) 145–176 (ASM Press, Washington DC, 1994). 10.1128/9781555818364.ch11

[2]

Phillips, R. A. Water and electrolyte losses in cholera. Fed. Proc. 23, 705–718 (1964).

[3]

Wilhelmi, I., Roman, E. & Sanchez-Fauquier, A. Viruses causing gastroenteritis. Clin. Microbiol. Infect. 9, 247–262 (2003). 10.1046/j.1469-0691.2003.00560.x

[4]

Lysogenic Conversion by a Filamentous Phage Encoding Cholera Toxin

Matthew K. Waldor, John J. Mekalanos

Science 1996 10.1126/science.272.5270.1910

[5]

Schmidt, H. & Hensel, M. Pathogenicity islands in bacterial pathogenesis. Clin. Microbiol. Rev. 17, 14–56 (2004). 10.1128/cmr.17.1.14-56.2004

[6]

Cornelis, G. R. The Yersinia Ysc–Yop ‘type III’ weaponry. Nature Rev. Mol. Cell Biol. 3, 742–752 (2002). 10.1038/nrm932

[7]

Christie, P. J. & Vogel, J. P. Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells. Trends Microbiol. 8, 354–360 (2000). 10.1016/s0966-842x(00)01792-3

[8]

Brake, D. A. Parasites and immune responses: memory illusion? DNA Cell Biol. 22, 405–419 (2003). 10.1089/104454903767650676

[9]

Crowe, S., Zhu, T. & Muller, W. A. The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection. J. Leukoc. Biol. 74, 635–641 (2003). 10.1189/jlb.0503204

[10]

Jarvis, M. A. & Nelson, J. A. Human cytomegalovirus persistence and latency in endothelial cells and macrophages. Curr. Opin. Microbiol. 5, 403–407 (2002). 10.1016/s1369-5274(02)00334-x

[11]

Johnson, W. E. & Desrosiers, R. C. Viral persistance: HIV's strategies of immune system evasion. Annu. Rev. Med. 53, 499–518 (2002). 10.1146/annurev.med.53.082901.104053

[12]

Ernst, P. B. & Gold, B. D. The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Annu. Rev. Microbiol. 54, 615–640 (2000). 10.1146/annurev.micro.54.1.615

[13]

Valenzuela, M., Cerda, O. & Toledo, H. Overview on chemotaxis and acid resistance in Helicobacter pylori. Biol. Res. 36, 429–436 (2003).

[14]

Weeks, D. L., Eskandari, S., Scott, D. R. & Sachs, G. A H+-gated urea channel: the link between Helicobacter pylori urease and gastric colonization. Science 287, 482–485 (2000). 10.1126/science.287.5452.482

[15]

Molecular biology of microbial ureases

H L Mobley, M D Island, R P Hausinger

Microbiological Reviews 1995 10.1128/mr.59.3.451-480.1995

[16]

Smith, M. F. Jr et al. Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-κB activation and chemokine expression by epithelial cells. J. Biol. Chem. 278, 32552–32560 (2003). 10.1074/jbc.m305536200

[17]

Lee, S. K. et al. Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5. Microbes Infect. 5, 1345–1356 (2003). 10.1016/j.micinf.2003.09.018

[18]

Gewirtz, A. T. et al. Helicobacter pylori flagellin evades Toll-like receptor 5-mediated innate immunity. J. Infect. Dis. 189, 1914–1920 (2004). 10.1086/386289

[19]

Rhen, M., Eriksson, S., Clements, M., Bergstrom, S. & Normark, S. J. The basis of persistent bacterial infections. Trends Microbiol. 11, 80–86 (2003). 10.1016/s0966-842x(02)00038-0

[20]

Gebert, B., Fischer, W., Weiss, E., Hoffmann, R. & Haas, R. Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation. Science 301, 1099–1102 (2003). 10.1126/science.1086871

[21]

Umehara, S., Higashi, H., Ohnishi, N., Asaka, M. & Hatakeyama, M. Effects of Helicobacter pylori CagA protein on the growth and survival of B lymphocytes, the origin of MALT lymphoma. Oncogene 22, 8337–8842 (2003). 10.1038/sj.onc.1207028

[22]

Bode, G., Malfertheiner, P. & Ditschuneit, H. Pathogenetic implications of ultrastructural findings in Campylobacter pylori related gastroduodenal disease. Scand. J. Gastroenterol. Suppl. 142, 25–39 (1988). 10.3109/00365528809091710

[23]

Foliguet, B., Vicari, F., Guedenet, J. C., De Korwin, J. D. & Marchal, L. Scanning electron microscopic study of Campylobacter pylori and associated gastroduodenal lesions [in French]. Gastroenterol. Clin. Biol. 13, 65B–70B (1989).

[24]

Amieva, M. R., Salama, N. R., Tompkins, L. S. & Falkow, S. Helicobacter pylori enter and survive within multivesicular vacuoles of epithelial cells. Cell. Microbiol. 4, 677–690 (2002). 10.1046/j.1462-5822.2002.00222.x

[25]

Semino-Mora, C. et al. Intracellular and interstitial expression of Helicobacter pylori virulence genes in gastric precancerous intestinal metaplasia and adenocarcinoma. J. Infect. Dis. 187, 1165–1177 (2003). 10.1086/368133

[26]

Israel, D. A. et al. Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc. Natl Acad. Sci. USA 98, 14625–14630 (2001). 10.1073/pnas.251551698

[27]

Philpott, D. J. et al. Reduced activation of inflammatory responses in host cells by mouse-adapted Helicobacter pylori isolates. Cell. Microbiol. 4, 285–296 (2002). 10.1046/j.1462-5822.2002.00189.x

[28]

Azuma, T. et al. Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer. J. Infect. Dis. 189, 820–827 (2004). 10.1086/381782

[29]

Aras, R. A. et al. Natural variation in populations of persistently colonizing bacteria affect human host cell phenotype. J. Infect. Dis. 188, 486–496 (2003). 10.1086/377098

[30]

Loughlin, M. F., Barnard, F. M., Jenkins, D., Sharples, G. J. & Jenks, P. J. Helicobacter pylori mutants defective in RuvC Holliday junction resolvase display reduced macrophage survival and spontaneous clearance from the murine gastric mucosa. Infect. Immun. 71, 2022–2031 (2003). 10.1128/iai.71.4.2022-2031.2003

[31]

Wain, J. et al. Molecular typing of multiple-antibiotic-resistant Salmonella enterica serovar Typhi from Vietnam: application to acute and relapse cases of typhoid fever. J. Clin. Microbiol. 37, 2466–2472 (1999). 10.1128/jcm.37.8.2466-2472.1999

[32]

Levine, M. M., Black, R. E. & Lanata, C. Precise estimation of the numbers of chronic carriers of Salmonella typhi in Santiago, Chile, an endemic area. J. Infect. Dis. 146, 724–726 (1982). 10.1093/infdis/146.6.724

[33]

Wain, J. et al. Quantitation of bacteria in bone marrow from patients with typhoid fever: relationship between counts and clinical features. J. Clin. Microbiol. 39, 1571–1576 (2001). 10.1128/jcm.39.4.1571-1576.2001

[34]

Sinnott, C. R. & Teall, A. J. Persistent gallbladder carriage of Salmonella typhi. Lancet 1 (8539), 976 (1987). 10.1016/s0140-6736(87)90319-9

[35]

Monack, D. M., Bouley, D. M. & Falkow, S. Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+/+ mice and can be reactivated by IFNγ neutralization. J. Exp. Med. 199, 231–241 (2004). 10.1084/jem.20031319

[36]

Vidal, S. M., Malo, D., Vogan, K., Skamene, E. & Gros, P. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 73, 469–485 (1993). 10.1016/0092-8674(93)90135-d

[37]

Merrell, D. S. & Camilli, A. Information overload: assigning genetic functionality in the age of genomics and large-scale screening. Trends Microbiol. 10, 571–574 (2002). 10.1016/s0966-842x(02)02474-5

[38]

Koehler, J. E. in Persistent Bacterial Infections (eds Nataro, J. M. & Blaser, M. J.) 339–353 (ASM Press, Washington DC, 2000). 10.1128/9781555818104.ch17

[39]

Koehler, J. E., Glaser, C. A. & Tappero, J. W. Rochalimaea henselae infection. A new zoonosis with the domestic cat as reservoir. J. Am. Med. Assoc. 271, 531–535 (1994). 10.1001/jama.1994.03510310061039

[40]

Schulein, R. et al. Invasion and persistent intracellular colonization of erythrocytes. A unique parasitic strategy of the emerging pathogen Bartonella. J. Exp. Med. 193, 1077–1086 (2001). 10.1084/jem.193.9.1077

[41]

Koehler, J. E., Quinn, F. D., Berger, T. G., LeBoit, P. E. & Tappero, J. W. Isolation of Rochalimaea species from cutaneous and osseous lesions of bacillary angiomatosis. N. Engl. J. Med. 327, 1625–1631 (1992). 10.1056/nejm199212033272303

[42]

Koesling, J., Aebischer, T., Falch, C., Schulein, R. & Dehio, C. Cutting edge: antibody-mediated cessation of hemotropic infection by the intraerythrocytic mouse pathogen Bartonella grahamii. J. Immunol. 167, 11–14 (2001). 10.4049/jimmunol.167.1.11

[43]

Capo, C., Amirayan-Chevillard, N., Brouqui, P., Raoult, D. & Mege, J. L. Bartonella quintana bacteremia and overproduction of interleukin-10: model of bacterial persistence in homeless people. J. Infect. Dis. 187, 837–844 (2003). 10.1086/368384

[44]

Urban, B. C. et al. Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells. Nature 400, 73–77 (1999). 10.1038/21900

[45]

Schulein, R. & Dehio, C. The VirB/VirD4 type IV secretion system of Bartonella is essential for establishing intraerythrocytic infection. Mol. Microbiol. 46, 1053–1067 (2002). 10.1046/j.1365-2958.2002.03208.x

[46]

Watarai, M., Makino, S. & Shirahata, T. An essential virulence protein of Brucella abortus, VirB4, requires an intact nucleoside-triphosphate-binding domain. Microbiology 148, 1439–1446 (2002). 10.1099/00221287-148-5-1439

[47]

Jenkins, M. K. et al. In vivo activation of antigen-specific CD4 T cells. Annu. Rev. Immunol. 19, 23–45 (2001). 10.1146/annurev.immunol.19.1.23

[48]

Mascie-Taylor, C. G. & Karim, E. The burden of chronic disease. Science 302, 1921–1922 (2003). 10.1126/science.1092488

[49]

Gubler, D. J. Resurgent vector-borne diseases as a global health problem. Emerg. Infect. Dis. 4, 442–450 (1998). 10.3201/eid0403.980326

[50]

Hilbi, H. et al. Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB. J. Biol. Chem. 273, 32895–32900 (1998). 10.1074/jbc.273.49.32895

Showing 50 of 66 references

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Published: Jul 08, 2004
Vol/Issue: 430(6996)
Pages: 250-256
License: View

Authors

D

D. Scott Merrell

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, Maryland 20814

S

Stanley Falkow

Cite This Article

D. Scott Merrell, Stanley Falkow (2004). Frontal and stealth attack strategies in microbial pathogenesis. Nature, 430(6996), 250-256. https://doi.org/10.1038/nature02760

Frontal and stealth attack strategies in microbial pathogenesis

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