journal article May 01, 2002

AP-1 as a regulator of cell life and death

View at Publisher Save 10.1038/ncb0502-e131
Topics

No keywords indexed for this article. Browse by subject →

References
98
[1]
Angel, P. & Karin, M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochem. Biophys. Acta 1072, 129–157 (1991).
[2]
Chimenov, Y. & Kerppola, T. K. Close encounters of many kinds: Fos–Jun interactions that mediate transcription regulatory specificity. Oncogene 6, 533–542 (2001).
[3]
Ryseck, R. P. & Bravo, R. cJun, JunB, and JunD differ in their binding affinities to the AP-1 and CRE consensus sequences: effect of Fos proteins. Oncogene 6, 533–542 (1991).
[4]
Schutte, J. et al. JunB inhibits and cFos stimulates the transforming and transactivating activities of cJun. Cell 59, 987–997 (1989). 10.1016/0092-8674(89)90755-1
[5]
Chiu, R., Angel, P. & Karin, M. JunB differs in its biological properties from, and is a negative regulator of c-Jun. Cell 59, 979–986 (1989). 10.1016/0092-8674(89)90754-x
[6]
Karin, M. The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270, 16483–16486 (1995). 10.1074/jbc.270.28.16483
[7]
Karin, M., Liu, Z.-G. & Zandi, E. AP-1 function and regulation. Curr. Opin. Cell Biol. 9, 240–246 (1997). 10.1016/s0955-0674(97)80068-3
[8]
Schreiber, M. et al. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev. 13, 607–619 (1999). 10.1101/gad.13.5.607
[9]
Passegue, E. & Wagner, E. F. JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression. EMBO J. 19, 2969–2979 (2000). 10.1093/emboj/19.12.2969
[10]
Shaulian, E. et al. The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell 103, 897–907 (2000). 10.1016/s0092-8674(00)00193-8
[11]
Pessah, M. et al. c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity. Proc. Natl Acad. Sci. USA 98, 6198–6120 (2001). 10.1073/pnas.101579798
[12]
Hsu, J. C., Cressman, D. E. & Taub, R. Promoter-specific trans-activation and inhibition mediated by JunB. Cancer Res. 53, 3789–3794 (1993).
[13]
Mammalian MAP kinase signalling cascades

Lufen Chang, Michael Karin

Nature 2001 10.1038/35065000
[14]
Hill, C. S., Wynne, J. & Treisman, R. Serum-regulated transcription by serum response factor (Srf) – a novel role for the DNA binding domain. EMBO J. 13, 5421–5432 (1994). 10.1002/j.1460-2075.1994.tb06877.x
[15]
Gruda, M. C., Kovary, K., Metz, R. & Bravo, R. Regulation of Fra-1 and Fra-2 phosphorylation differs during the cell cycle of fibroblasts and phosphorylation in vitro by MAP kinase affects DNA binding activity. Oncogene 9, 2537–2547 (1994).
[16]
Kato, Y. et al. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. EMBO J. 16, 7054–7066 (1997). 10.1093/emboj/16.23.7054
[17]
Cavigelli, M., Dolfi, F., Claret, F. X. & Karin, M. Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO J. 14, 5957–5964 (1995). 10.1002/j.1460-2075.1995.tb00284.x
[18]
Gupta, S., Campbell, D., Dérijard, B. & Davis, R. J. Transcription factor ATF2: regulation by the JNK signal transduction pathway. Science 267, 389–393 (1995). 10.1126/science.7824938
[19]
Devary, Y., Gottlieb, R. A., Lau, L. & Karin, M. Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol. Cell. Biol. 11, 2804–2811 (1991).
[20]
Schonthal, A., Herrlich, P., Rahmsdorf, H. J. & Ponta, H. Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters. Cell 54, 325–334 (1988). 10.1016/0092-8674(88)90195-x
[21]
Hibi, M., Lin, A., Smeal, T., Minden, A. & Karin, M. Identification of an oncoprotein-responsive and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7, 2135–2148 (1993). 10.1101/gad.7.11.2135
[22]
Dérijard, B. et al. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025–1037 (1994). 10.1016/0092-8674(94)90380-8
[23]
Han, J., Jiang, Y., Li, Z., Kravchenko, V. V. & Ulevitch, R. J. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature 386, 296–299 (1997). 10.1038/386296a0
[24]
Shaulian, E. & Karin, M. AP-1 in cell proliferation and survival. Oncogene 20, 2390–2400 (2001). 10.1038/sj.onc.1204383
[25]
Kovary, K. & Bravo, R. The jun and fos protein families are both required for cell cycle progression in fibroblasts. Mol. Cell. Biol. 11, 4466–4472 (1991).
[26]
Brown, J. R. et al. Fos family members induce cell cycle entry by activating cyclin D1. Mol. Cell Biol. 18, 5609–5619 (1998). 10.1128/mcb.18.9.5609
[27]
Brusselbach, S. et al. Cell proliferation and cell cycle progression are not impaired in fibroblasts and ES cells lacking c-Fos. Oncogene 10, 79–86 (1995).
[28]
Thepot, D. et al. Targeted disruption of the murine junD gene results in multiple defects in male reproductive function. Development 127, 143–153 (2000). 10.1242/dev.127.1.143
[29]
Behrens, A., Sibilia, M. & Wagner, E. F. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nature Genet. 21, 326–329 (1999). 10.1038/6854
[30]
Johnson, R. S., van Lingen, B., Papaioannou, V. E. & Spiegelman, B. W. A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev. 7, 1309–1317 (1993). 10.1101/gad.7.7b.1309
[31]
Eferl, R. et al. Functions of c-jun in liver and heart development. J. Cell Biol. 145, 1049–1061 (1999). 10.1083/jcb.145.5.1049
[32]
c-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal–Epidermal Interaction in Skin

Axel Szabowski, Nicole Maas-Szabowski, Sven Andrecht et al.

Cell 2000 10.1016/s0092-8674(00)00178-1
[33]
Wisdom, R., Johnson, R. S. & Moore, C. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J. 18, 188–197 (1999). 10.1093/emboj/18.1.188
[34]
Xiong, Y. et al. p21 is a universal inhibitor of cyclin kinases. Nature 366, 701–704 (1993). 10.1038/366701a0
[35]
WAF1, a potential mediator of p53 tumor suppression

Wafik S. El-Deiry, Takashi Tokino, Victor E. Velculescu et al.

Cell 1993 10.1016/0092-8674(93)90500-p
[36]
Clark, W. et al. v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E–cdk2 catalytic activity. Mol. Cell Biol. 20, 2529–2542 (2000). 10.1128/mcb.20.7.2529-2542.2000
[37]
Hennigan, R. F. & Stambrook, P. J. Dominant negative c-jun inhibits activation of the cyclin D1 and cyclin E kinase complexes. Mol. Biol. Cell 12, 2352–2363 (2001). 10.1091/mbc.12.8.2352
[38]
Schutte, J., Minna, J. D. & Birrer, M. Deregulated expression of human {Ic-jun} transforms primary rat embryo cells in cooperation with and activated c-Ha-{Iras} gene and transforms Rat-la cells as a single gene. Proc. Natl Acad. Sci. USA 86, 2257–2261 (1989). 10.1073/pnas.86.7.2257
[39]
Schorpp-Kistner, M., Wang, Z. Q., Angel, P. & Wagner, E. F. JunB is essential for mammalian placentation. EMBO J. 18, 934–948 (1999). 10.1093/emboj/18.4.934
[40]
Bakiri, L., Lallemand, D., Bossy-Wetzel, E. & Yaniv, M. Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression. EMBO J. 19, 2056–2068 (2000). 10.1093/emboj/19.9.2056
[41]
Passegue, E., Jochum, W., Schorpp-Kistner, M., Mohle-Steinlein, U. & Wagner, E. F. Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage. Cell 104, 21–32 (2001). 10.1016/s0092-8674(01)00188-x
[42]
Passegue, E., Jochum, W., Behrens, A., Ricci, R. & Wagner, E. JunB can substitute for c-Jun in mouse development and cell proliferation. Nature Genet. 30, 158–166 (2002). 10.1038/ng790
[43]
Weitzman, J. B., Fiette, L., Matsuo, K. & Yaniv, M. JunD protects cells from p53-dependent senescence and apoptosis. Mol. Cell 6, 1109–1119 (2000). 10.1016/s1097-2765(00)00109-x
[44]
Sherr, C. J. Tumor surveillance via the ARF-p53 pathway. Genes Dev. 12, 2984–2991 (1998). 10.1101/gad.12.19.2984
[45]
Agarwal, S. K. et al. Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell 96, 143–152 (1999). 10.1016/s0092-8674(00)80967-8
[46]
Pfarr, C. M. et al. Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras. Cell 76, 747–760 (1994). 10.1016/0092-8674(94)90513-4
[47]
Maki, Y., Bos, T. J., Davis, C., Starbuck, M. & Vogt, P. K. Avian sarcoma cirus 17 carries the Jun oncogene. Proc. Natl Acad. Sci. USA 84, 2848–2852 (1987). 10.1073/pnas.84.9.2848
[48]
van Straaten, F., Muller, R., Curran, T., Van Beveren, C. & Verma, I. M. Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein. Proc. Natl Acad. Sci. USA 80, 3183–3187 (1983). 10.1073/pnas.80.11.3183
[49]
Vandel, L. et al. Stepwise transformation of rat embryo fibroblasts: c-Jun, JunB, or JunD can cooperate with Ras for focus formation, but a c-Jun-containing heterodimer is required for immortalization. Mol. Cell. Biol. 16, 1881–1888 (1996). 10.1128/mcb.16.5.1881
[50]
Johnson, R., Spiegelman, B., Hanahan, D. & Wisdom, R. Cellular transformation and malignancy induced by ras require c-jun. Mol. Cell. Biol. 16, 4504–4511 (1996). 10.1128/mcb.16.8.4504

Showing 50 of 98 references

Cited By
2,461
Axon injury signaling and compartmentalized injury response in glaucoma

Stephanie B. Syc-Mazurek, Richard T. Libby · 2019

Progress in Retinal and Eye Researc...
Biology Open
Biochimica et Biophysica Acta (BBA)...
Proceedings of the National Academy...
Metrics
2,461
Citations
98
References
Details
Published
May 01, 2002
Vol/Issue
4(5)
Pages
E131-E136
License
View
Cite This Article
Eitan Shaulian, Michael Karin (2002). AP-1 as a regulator of cell life and death. Nature Cell Biology, 4(5), E131-E136. https://doi.org/10.1038/ncb0502-e131