Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

Michel Enamorado; Salvador Iborra; Elena Priego; Francisco J. Cueto; Juan A. Quintana; Sarai Martínez-Cano; Ernesto Mejías-Pérez; Mariano Esteban; Ignacio Melero; Andres Hidalgo; David Sancho

doi:10.1038/ncomms16073

journal article Open Access Jul 17, 2017

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

Michel Enamorado

Salvador Iborra

Elena Priego Francisco J. Cueto

Juan A. Quintana Sarai Martínez-Cano Ernesto Mejías-Pérez Mariano Esteban

Ignacio Melero

Andres Hidalgo

David Sancho

Nature Communications Vol. 8 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/ncomms16073

Abstract

AbstractThe goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8+ T cells with a resident memory (Trm) phenotype correlates with improved survival. However, the interplay of circulating CD8+ T cells and Trm cells remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune the generation of Trm cells or circulating memory T cells, here we show that, while both subsets are sufficient for anti-tumour immunity, the presence of Trm cells improves anti-tumour efficacy. Transferred central memory T cells (Tcm) generate Trm cells following viral infection or tumour challenge. Anti-PD-1 treatment promotes infiltration of transferred Tcm cells within tumours, improving anti-tumour immunity. Moreover, Batf3-dependent dendritic cells are essential for reactivation of circulating memory anti-tumour response. Our findings show the plasticity, collaboration and requirements for reactivation of memory CD8+ T cells subsets needed for optimal tumour vaccination and immunotherapy.

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Details

Published: Jul 17, 2017
Vol/Issue: 8(1)
License: View

Authors

M

Michel Enamorado

Systems Biology Department, Center of Molecular Immunology , Havana, CP 11600,

The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain; Tumour Immunology Lab, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain; Department of Medical Oncology, La Paz University Hospital, 28046 Madrid, Spain

Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologı́a, CSIC, Campus Universidad Autónoma, 28049 Madrid, Spain

I

Ignacio Melero

CIMA, CUN, University Navarra, Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Pamplona, Spain;

Cite This Article

Michel Enamorado, Salvador Iborra, Elena Priego, et al. (2017). Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells. Nature Communications, 8(1). https://doi.org/10.1038/ncomms16073

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

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