A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia

Maria Chiara Di Bernardo; Dalemari Crowther-Swanepoel; Peter Broderick; Emily Webb; Gabrielle Sellick; Ruth Wild; Kate Sullivan; Jayaram Vijayakrishnan; Yufei Wang; Alan M Pittman; Nicola J Sunter; Andrew G Hall; Martin J S Dyer; Estella Matutes; Claire Dearden; Tryfonia Mainou-Fowler; Graham H Jackson; Geoffrey Summerfield; Robert J Harris; Andrew R Pettitt; Peter Hillmen; David J Allsup; James R Bailey; Guy Pratt; Chris Pepper; Chris Fegan; James M Allan; Daniel Catovsky; Richard S Houlston

doi:10.1038/ng.219

journal article Aug 31, 2008

A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia

Maria Chiara Di Bernardo Dalemari Crowther-Swanepoel Peter Broderick Emily Webb

Gabrielle Sellick Ruth Wild Kate Sullivan Jayaram Vijayakrishnan Yufei Wang

Alan M Pittman Nicola J Sunter Andrew G Hall Martin J S Dyer Estella Matutes Claire Dearden Tryfonia Mainou-Fowler Graham H Jackson Geoffrey Summerfield Robert J Harris Andrew R Pettitt Peter Hillmen

David J Allsup James R Bailey Guy Pratt Chris Pepper Chris Fegan James M Allan Daniel Catovsky Richard S Houlston

Nature Genetics Vol. 40 No. 10 pp. 1204-1210 · Springer Science and Business Media LLC

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References

28

[1]

Sellick, G.S., Catovsky, D. & Houlston, R.S. Familial chronic lymphocytic leukemia. Semin. Oncol. 33, 195–201 (2006). 10.1053/j.seminoncol.2006.01.013

[2]

Raval, A. et al. Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell 129, 879–890 (2007). 10.1016/j.cell.2007.03.043

[3]

Sellick, G.S. et al. A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia. Blood 110, 3326–3333 (2007). 10.1182/blood-2007-05-091561

[4]

Power, C. & Elliott, J. Cohort profile: 1958 British birth cohort (National Child Development Study). Int. J. Epidemiol. 35, 34–41 (2006). 10.1093/ije/dyi183

[5]

Pfeifer, D. et al. Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays. Blood 109, 1202–1210 (2007). 10.1182/blood-2006-07-034256

[6]

Busslinger, M. Transcriptional control of early B cell development. Annu. Rev. Immunol. 22, 55–79 (2004). 10.1146/annurev.immunol.22.012703.104807

[7]

Klein, U. & Dalla-Favera, R. Germinal centres: role in B-cell physiology and malignancy. Nat. Rev. Immunol. 8, 22–33 (2008). 10.1038/nri2217

[8]

Shapiro-Shelef, M. & Calame, K. Regulation of plasma-cell development. Nat. Rev. Immunol. 5, 230–242 (2005). 10.1038/nri1572

[9]

Bloch, D.B., de la Monte, S.M., Guigaouri, P., Filippov, A. & Bloch, K.D. Identification and characterization of a leukocyte-specific component of the nuclear body. J. Biol. Chem. 271, 29198–29204 (1996). 10.1074/jbc.271.46.29198

[10]

Dent, A.L. et al. LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies. Blood 88, 1423–1426 (1996). 10.1182/blood.v88.4.1423.bloodjournal8841423

[11]

Ling, P.D. et al. Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100. EMBO J. 24, 3565–3575 (2005). 10.1038/sj.emboj.7600820

[12]

Madani, N. et al. Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1. J. Virol. 76, 11133–11138 (2002). 10.1128/jvi.76.21.11133-11138.2002

[13]

Oliver, P.M. et al. Loss of Bim allows precursor B cell survival but not precursor B cell differentiation in the absence of interleukin 7. J. Exp. Med. 200, 1179–1187 (2004). 10.1084/jem.20041129

[14]

Kovalevska, L.M. et al. Immunohistochemical studies of protein kinase D (PKD) 2 expression in malignant human lymphomas. Exp. Oncol. 28, 225–230 (2006).

[15]

Hamblin, T.J., Davis, Z., Gardiner, A., Oscier, D.G. & Stevenson, F.K. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94, 1848–1854 (1999). 10.1182/blood.v94.6.1848

[16]

Damle, R.N. et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 94, 1840–1847 (1999). 10.1182/blood.v94.6.1840

[17]

Weiss, N.S. Geographical variation in the incidence of the leukemias and lymphomas. Natl. Cancer Inst. Monogr. 53, 139–142 (1979).

[18]

Catovsky, D. et al. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial. Lancet 370, 230–239 (2007). 10.1016/s0140-6736(07)61125-8

[19]

Sayala, H. et al. Final report of the UKCLL02 trial: A phase II study of subcutaneous alemtuzumab plus fludarabine in patients with fludarabine refractory CLL (on behalf of the NCRI CLL trials sub-group). Blood (ASH Annual Meeting Abstracts) 108, 34 (2006). 10.1182/blood.v108.11.34.34

[20]

Allan, J.M. et al. Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia. Proc. Natl. Acad. Sci. USA 98, 11592–11597 (2001). 10.1073/pnas.191211198

[21]

van Krieken, J.H. et al. Improved reliability of lymphoma diagnostics via PCR-based clonality testing: report of the BIOMED-2 Concerted Action BHM4–CT98–3936. Leukemia 21, 201–206 (2007). 10.1038/sj.leu.2404467

[22]

Petitti, D. Meta-analysis Decision Analysis and Cost-Effectiveness Analysis (Oxford Univ. Press, New York, 1994).

[23]

Higgins, J.P. & Thompson, S.G. Quantifying heterogeneity in a meta-analysis. Stat. Med. 21, 1539–1558 (2002). 10.1002/sim.1186

[24]

Cox, A. et al. A common coding variant in CASP8 is associated with breast cancer risk. Nat. Genet. 39, 352–358 (2007). 10.1038/ng1981

[25]

Goldin, L.R., Pfeiffer, R.M., Li, X. & Hemminki, K. Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database. Blood 104, 1850–1854 (2004). 10.1182/blood-2004-01-0341

[26]

Stranger, B.E. et al. Genome-wide associations of gene expression variation in humans. PLoS Genet. 1, e78 (2005). 10.1371/journal.pgen.0010078

[27]

Stranger, B.E. et al. Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science 315, 848–853 (2007). 10.1126/science.1136678

[28]

Cuzick, J.A. Wilcoxon-type test for trend. Stat. Med. 4, 87–90 (1985). 10.1002/sim.4780040112

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Published: Aug 31, 2008
Vol/Issue: 40(10)
Pages: 1204-1210
License: View

Authors

M

Maria Chiara Di Bernardo

D

Dalemari Crowther-Swanepoel

Jayaram Vijayakrishnan

Tryfonia Mainou-Fowler

Cite This Article

Maria Chiara Di Bernardo, Dalemari Crowther-Swanepoel, Peter Broderick, et al. (2008). A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Nature Genetics, 40(10), 1204-1210. https://doi.org/10.1038/ng.219

A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia

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