Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Dominique Bonnet; John E. Dick

doi:10.1038/nm0797-730

journal article Jul 01, 1997

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Dominique Bonnet

John E. Dick

Nature Medicine Vol. 3 No. 7 pp. 730-737 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/nm0797-730

Topics

No keywords indexed for this article. Browse by subject →

References

39

[1]

Fialkow, P. et al. Clonal development, stem-cell differentiation, and clinical remission in acute nonlymphocytic leukemia. N. Engl. J. Med. 317, 468–473 (1987). 10.1056/nejm198708203170802

[2]

McCulloch, E. Stem cells in normal and leukemic hemopoiesis (Henry StrattonLecture). Blood 62, 1–13 (1983). 10.1182/blood.v62.1.1.1

[3]

Griffin, J. & Löwenberg, B. Clonogenic cells in acute myeloblastic leukemia. Blood 68, 1185–1195 (1986). 10.1182/blood.v68.6.1185.1185

[4]

Cline, M.J. The molecular basis of leukemia. N. Engl. J. Med. 330, 328–336 (1994). 10.1056/nejm199402033300507

[5]

Berger, R. et al. Cytogenetic studies on 519 consecutive de novo acute nonlympho cytic leukemias. Cancer Genet. Cytogenet. 29, 9–21 (1987). 10.1016/0165-4608(87)90026-4

[6]

Bennett, J. et al. Proposals for the classification of the acute leukemias. Br. J. Haematol. 33, 451–458 (1976). 10.1111/j.1365-2141.1976.tb03563.x

[7]

Fialkow, P.J. et al. Acute nonlymphocytic leukemia: Heterogeneity of stem cell origin. Blood 57, 1068–1073 (1981). 10.1182/blood.v57.6.1068.bloodjournal5761068

[8]

Bartram, C.R. et al. Acute myeloid leukemia: Analysis of ras gene mutations and clonality defined by polymorphic X-linked loci. Leukemia 3, 247–256 (1989).

[9]

van Lorn, K., Hagemeijer, A., Smit, E.M. & Lowenberg, B. In situ hybridization on May-Grünwald Giemsa-stained bone marrow and blood smears of patients with hematologic disorders allows detection of cell-lineage-specific cytogenetic abnormalities. Blood 82, 884–888 (1993). 10.1182/blood.v82.3.884.884

[10]

Fearon, E., Burke, P., Schiffer, C., Zehnbauer, B. & Vogelstein, B. Differentiation of leukemia cells to polymorphonuclear leukocytes in patients with acute nonlymphoblastic leukemia. N. Engl. J. Med. 315, 15–24 (1986). 10.1056/nejm198607033150103

[11]

Feuring-Buske, M. et al. Trisomy 4 in ‘stem cell-like’ leukemic cells of a patient with AML. Leukemia 9, 1318–1320 (1995).

[12]

Greaves, M.F. Stem cell origins of leukaemia and curability. Br. J. Cancer 67, 413–423 (1993). 10.1038/bjc.1993.81

[13]

Keinänen, M., Griffin, J., Bloomfield, C., Machnrcki, J. & de la Chapelle, A. Clonalchromosomal abnormalities showing multiple-cell-lineage involvement in acute myeloid leukemia. N. Engl.J. Med. 318, 1153–1158 (1988). 10.1056/nejm198805053181803

[14]

McCulloch, E.A. et al. Heterogeneity in acute myeloblastic leukemia. Leukemia 2, 38S–49S (1988).

[15]

Evidence for malignant transformation in acute myeloid leukemia at the level of early hematopoietic stem cells by cytogenetic analysis of CD34+ subpopulations

D Haase, M Feuring-Buske, S Konemann et al.

Blood 1995 10.1182/blood.v86.8.2906.2906

[16]

Mehrotra, B. et al. Cytogenetically aberrant cells in the stem cell compartment (CD34+1in−) in acute myeloid leukemia. Blood 86, 1139–1147 (1995).

[17]

Larochelle, A. et al. Identification of primitive hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy. Nature Med. 2, 1329–1337 (1996). 10.1038/nm1296-1329

[18]

Dick, J.E. Normal and leukemic stem cells assayed in SCID mice. Semin. Immunol. 8, 197–206 (1996). 10.1006/smim.1996.0025

[19]

Bhatia, M., Wang, J., Kapp, U., Bonnet, D. & Dick, J. Purification of primitive human hematopoietic cells capable of repopulating NOD/SCID mice. Proc. Natl.Acad. Sci.USA 94, 5320–5325 (1997). 10.1073/pnas.94.10.5320

[20]

Lapidot, T. et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367, 645–648 (1994). 10.1038/367645a0

[21]

Larochelle, A. et al. Engraftment of immune-deficient mice with primitivehematopoietic cells from beta-thalassemia and sickle cell anemia patients:Implications for evaluating human gene therapy protocols. Hum. Mol. Genet. 4, 163–172 (1995). 10.1093/hmg/4.2.163

[22]

Wang, J., Doedens, M. & Dick, J. Primitive human hematopoietic cells are enrichedin cord blood compared to adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell (SRC) assay. Blood 89, 3919–3924 (1997). 10.1182/blood.v89.11.3919

[23]

Porter, E. & Berry, R. The efficient design of transplantable tumor assays. Br. J. Cancer 17, 583–595 (1964). 10.1038/bjc.1963.78

[24]

Taswell, C. Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. J. Immunol. 126, 1614–1619 (1981). 10.4049/jimmunol.126.4.1614

[25]

Civin, C. et al. Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1 a cells. J. Immunol. 133, 157–165 (1984). 10.4049/jimmunol.133.1.157

[26]

Terstappen, L.W.W.M., Huang, S., Safford, M., Lansdorp, P.M. & Loken, M.R. Sequential generations of hematopoietic colonies derived from single nonlineagecommitted CD34+CD38 progenitor cells. Blood 77, 1218–1227 (1991). 10.1182/blood.v77.6.1218.1218

[27]

Terstappen, L. et al. Flow cytometry characterization of acute myeloid leukemia: IV. Comparison to the differentiation pathway of normal hematopoietic cells. Leukemia 6, 993–1000 (1992).

[28]

Cashman, J. et al. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Stood (in the press).

[29]

Moore, M., Williams, N. & Metcalfe, D. In vitro colony formation by normal and leukemic human hematopoietic cells: Characterization of the colony-forming cells. J. Natl. Cancer Inst. 50, 603 (1974). 10.1093/jnci/50.3.603

[30]

Sutherland, H., Blair, A. & Zapf, R.W. Characterization of a hierarchy in human acute myeloid leukemia progenitor cells. Blood 87, 4754–4761 (1996). 10.1182/blood.v87.11.4754.bloodjournal87114754

[31]

Craig, W., Kay, R., Cutler, R.B. & Lansdorp, P.M. Expression of Thy-1 on human hematopoietic progenitor cells. J. Exp. Med. 177, 1331–1342 (1993). 10.1084/jem.177.5.1331

[32]

Terpstra, W. et al. Long-term leukemia-initiating capacity of a CD34− subpopulation of acute myeloid leukemia. Stood 87, 2187–2194 (1996).

[33]

Sawyers, C., Gishizky, M., Quan, S., Golde, D. & Witte, O. Propagation of human blastic myeloid leukemias in the SCID mouse. Blood 79, 2089–2098 (1992). 10.1182/blood.v79.8.2089.2089

[34]

Cesano, A. et al. The severe combined immunodeficient (SCID) mouse as a model for myeloid leukemias. Oncogene 7, 827–836 (1992).

[35]

Turhan, A.G. et al. Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate nonclonal progenitors in acute promyelocytic leukemia. Stood 85, 2154–2161 (1995).

[36]

Lapidot, T. et al. Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice. Science 255, 1137–1141 (1992). 10.1126/science.1372131

[37]

Vormoor, J. et al. Immature human cord blood progenitors engraft and proliferate to high levels in immune-deficient SCID mice. Stood 83, 2489–2497 (1994).

[38]

Sirard, C. et al. Normal and leukemic SCID-repopulating cells (SRC) co-exist in the bone marrow and peripheral blood from CML patients in chronic phase while leukemic SRC are detected in blast crisis. Stood 87, 1539–1548 (1996).

[39]

Structure, organization, and sequence of alpha satellite DNA from human chromosome 17: evidence for evolution by unequal crossing-over and an ancestral pentamer repeat shared with the human X chromosome.

J S Waye, H F Willard

Molecular and Cellular Biology 1986 10.1128/mcb.6.9.3156

Cited By

5,505

Cancer stem cells amino acid metabolism: Roles, mechanisms, and intervention strategies

Yi Gong, Xirui Wang · 2025

Cellular Signalling

CD44: a key regulator of iron metabolism, redox balance, and therapeutic resistance in cancer stem cells

Taiju Ando, Juntaro Yamasaki · 2025

Stem Cells

RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax

Junya Sango, Saul Carcamo · 2024

Nature

The Crossroads of Clonal Evolution, Differentiation Hierarchy, and Ontogeny in Leukemia Development

Christopher M. Sturgeon, Elvin Wagenblast · 2024

Blood Cancer Discovery

Hypoxia-inducible factors: cancer progression and clinical translation

Elizabeth E. Wicks, Gregg L. Semenza · 2022

Journal of Clinical Investigation

Anti-oncogenic activities exhibited by paracrine factors of MSCs can be mediated by modulation of KITLG and DKK1 genes in glioma SCs in vitro

Nazneen Aslam, Elham Abusharieh · 2021

Molecular Therapy - Oncolytics

Targeting metastatic cancer

Karuna Ganesh, Joan Massagué · 2021

Nature Medicine

Multi-Stability and Consequent Phenotypic Plasticity in AMPK-Akt Double Negative Feedback Loop in Cancer Cells

Adithya Chedere, Kishore Hari · 2021

Journal of Clinical Medicine

microRNA: The Impact on Cancer Stemness and Therapeutic Resistance

Xueqiao Jiao, Xianling Qian · 2019

Cells

Head and neck cancer management and cancer stem cells implication

Osama A. Elkashty, Ramy Ashry · 2019

The Saudi Dental Journal

Deferasirox selectively induces cell death in the clinically relevant population of leukemic CD34+CD38– cells through iron chelation, induction of ROS, and inhibition of HIF1α expression

Saar Shapira, Pia Raanani · 2019

Experimental Hematology

Metabolism as master of hematopoietic stem cell fate

Kyoko Ito, Massimo Bonora · 2018

International Journal of Hematology

NANOGP8 is the key regulator of stemness, EMT, Wnt pathway, chemoresistance, and other malignant phenotypes in gastric cancer cells

Xia Ma, Bei Wang · 2018

PLoS ONE

Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic Targets

Ryo Sato, Takashi Semba · 2016

Stem Cells

Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution

M Ryan Corces, Jason D Buenrostro · 2016

Nature Genetics

Cancer Stem Cells: Basic Concepts and Therapeutic Implications

Dany Nassar, Cédric Blanpain · 2016

Annual Review of Pathology: Mechani...

Progress and Prospects in Pediatric Leukemia

P. Pallavi Madhusoodhan, William L. Carroll · 2016

Current Problems in Pediatric and A...

Mass Cytometric Functional Profiling of Acute Myeloid Leukemia Defines Cell-Cycle and Immunophenotypic Properties That Correlate with Known Responses to Therapy

Gregory K. Behbehani, Nikolay Samusik · 2015

Cancer Discovery

Stem cells in gastric cancer

Yue Zhao · 2015

World Journal of Gastroenterology

Mechanisms of cryoablation: Clinical consequences on malignant tumors

J.G. Baust, A.A. Gage · 2014

Cryobiology

Metrics

5,505

Citations

39

References

Details

Published: Jul 01, 1997
Vol/Issue: 3(7)
Pages: 730-737
License: View

Authors

D

Dominique Bonnet

Haematopoietic Stem Cell Laboratory, Francis Crick Institute, London

J

John E. Dick

Cite This Article

Dominique Bonnet, John E. Dick (1997). Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Medicine, 3(7), 730-737. https://doi.org/10.1038/nm0797-730

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

You May Also Like